Evaluation of the mutagenicity of a-dihydroergocryptine in vitro and in vivo.

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Adams K, Allen JA, Brooker PC, Jones E, Proudlock RJ, Mailland F, Coppi G

Evaluation of the mutagenicity of a-dihydroergocryptine in vitro and in vivo.

Arzneimittelforschung. 1993 Dec;43(12):1253-7.

PubMed ID
8141809 [ View in PubMed
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Abstract

The mutagenic potential of the ergot alkaloid a-dihydroergocryptine (a-DEC, CAS 14271-05-7) was assessed in a series of 5 assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.

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