Novel thiazolidine-2,4-diones as potent euglycemic agents.

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Hulin B, Clark DA, Goldstein SW, McDermott RE, Dambek PJ, Kappeler WH, Lamphere CH, Lewis DM, Rizzi JP

Novel thiazolidine-2,4-diones as potent euglycemic agents.

J Med Chem. 1992 May 15;35(10):1853-64.

PubMed ID

1588563 [ View in PubMed

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Abstract

A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Darglitazone	Peroxisome proliferator-activated receptor gamma	Protein	Humans	Unknown	Agonist	Details