Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
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Soubeyran P, Barac A, Szymkiewicz I, Dikic I
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Biochem J. 2003 Feb 15;370(Pt 1):29-34.
- PubMed ID
- 12475393 [ View in PubMed]
- Abstract
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.