A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
Article Details
- CitationCopy to clipboard
Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
Science. 1995 Jul 14;269(5221):242-4.
- PubMed ID
- 7618087 [ View in PubMed]
- Abstract
CD22 is a membrane immunoglobulin (mIg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mIg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mIg. Ligation of CD22 to prevent its coaggregation with mIg lowers the threshold at which mIg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mIg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mIg signaling to anatomic sites rich in T cells.