Characteristic sequences in the upstream region of the human tyrosinase gene.
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Kikuchi H, Miura H, Yamamoto H, Takeuchi T, Dei T, Watanabe M
Characteristic sequences in the upstream region of the human tyrosinase gene.
Biochim Biophys Acta. 1989 Dec 22;1009(3):283-6.
- PubMed ID
- 2480811 [ View in PubMed]
- Abstract
A human tyrosinase gene containing a 5'-flanking region and the first exon was isolated from a normal human liver library using mouse tyrosinase cDNA as a probe for screening. In the 5'-upstream region of transcriptional start sites, there is a putative TATA box and CAAT box and some palindromic sequences. A characteristic sequence of (GA:TCn, which can assume a hinged-DNA structure, was present from -869 nt to -633 nt in this 5'-flanking region.