AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Article Details

Citation
Copy to clipboard

Hardie DG

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85.

PubMed ID
17712357 [ View in PubMed
]
Abstract

The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
5'-AMP-activated protein kinase subunit beta-1Q9Y478Details
5'-AMP-activated protein kinase catalytic subunit alpha-1Q13131Details
5'-AMP-activated protein kinase subunit beta-2O43741Details
5'-AMP-activated protein kinase catalytic subunit alpha-2P54646Details
5'-AMP-activated protein kinase subunit gamma-1P54619Details
5'-AMP-activated protein kinase subunit gamma-2Q9UGJ0Details
5'-AMP-activated protein kinase subunit gamma-3Q9UGI9Details