Structural biology of HIV.

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Turner BG, Summers MF

Structural biology of HIV.

J Mol Biol. 1999 Jan 8;285(1):1-32.

PubMed ID
9878383 [ View in PubMed
]
Abstract

The human immunodeficiency virus (HIV) genome encodes a total of three structural proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the past ten years have provided high-resolution three-dimensional structural information for all of the viral enzymes, structural proteins and envelope proteins, as well as for three of the accessory proteins. In some cases it has been possible to solve the structures of the intact, native proteins, but in most cases structural data were obtained for isolated protein domains, peptidic fragments, or mutants. Peptide complexes with two regulatory RNA fragments and a protein complex with an RNA recognition/encapsidation element have also been structurally characterized. This article summarizes the high-resolution structural information that is currently available for HIV proteins and reviews current structure-function and structure-biological relationships.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Gag-Pol polyproteinP03369Details
Gag-Pol polyproteinP12497Details
Gag-Pol polyproteinP35963Details
Gag-Pol polyproteinP12499Details
Gag-Pol polyproteinP04585Details
Gag-Pol polyproteinP04584Details
Gag-Pol polyproteinP03366Details
Gag-Pol polyproteinP03367Details
Gag-Pol polyproteinP04587Details