Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
Article Details
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Watts P, Satterfield D, Lim MK
Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.
J AAPOS. 2007 Jun;11(3):282-3.
- PubMed ID
- 17572343 [ View in PubMed]
- Abstract
Apraclonidine, a selective alpha(2)-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine.(1) An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil (Horner syndrome) due to its alpha(1)-effect on a pupil with denervation supersensitivity.(2) It has been used as a diagnostic test for Horner syndrome.(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Apraclonidine Alpha-1A adrenergic receptor Protein Humans YesAgonistDetails Apraclonidine Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails