Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
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Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik PB, Peffer NJ, Waldmann TA, et al.
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
Nature. 1984 Oct 18-24;311(5987):626-31.
- PubMed ID
- 6090948 [ View in PubMed]
- Abstract
We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.