Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.
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Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.
Nat Struct Mol Biol. 2005 Jun;12(6):554-5. Epub 2005 May 22.
- PubMed ID
- 15908963 [ View in PubMed]
- Abstract
The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.