Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma.
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Ho JC, Cheung ST, Poon WS, Lee YT, Ng IO, Fan ST
Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma.
J Cancer Res Clin Oncol. 2007 Dec;133(12):929-36. Epub 2007 May 12.
- PubMed ID
- 17497168 [ View in PubMed]
- Abstract
PURPOSE: Acyclic retinoid (ACR) has been shown to be a promising chemopreventive agent for hepatocellular carcinoma (HCC) after curative resection. The effects of retinoid are mediated by retinol-binding proteins (RBPs) through regulating cell proliferation and differentiation. PATIENTS AND METHODS: This study investigated the clinical significance of RBP5 in HCC. RBP5 mRNA level was examined by real-time quantitative PCR on 52 matched tumor and adjacent non-tumor liver tissues, and on ten normal livers. Expression of RBP5 protein was examined using Western blotting analysis and immunohistochemistry. RESULTS: Down-regulation of RBP5 was found in HCC tissues at both mRNA and protein levels. Decreased RBP5 level was closely related to poor differentiation (P=0.02) and large tumor size (P=0.01). Low level of RPB5 was associated with poor overall survival (P=0.02), and was an independent prognostic factor for HCC. CONCLUSIONS: Our study revealed that RBP5 down-regulation in HCC was associated with aggressive tumor features, suggesting an important role of RPB5 in HCC progression.