Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.
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Wang Z, Woolverton WL
Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.
Eur J Pharmacol. 2007 Feb 28;557(2-3):159-60. Epub 2006 Dec 1.
- PubMed ID
- 17196194 [ View in PubMed]
- Abstract
Histamine H1 receptor antagonists have some behavioral effects that predict abuse liability. In the present study, diphenhydramine and cocaine each maintained i.v. self-administration under a progressive-ratio schedule in rhesus monkeys. When cocaine and DPH were combined in a 1:1 ratio of the ED50s, the combination was super-additive in all monkeys. The data predict that the combination of cocaine and histamine H1 receptor antagonists would have enhanced potential for abuse relative to either drug alone.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Diphenhydramine Histamine H1 receptor Protein Humans YesAntagonistDetails