Rapid disease progression after the administration of bicalutamide in patients with metastatic prostate cancer.

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Laufer M, Sinibaldi VJ, Carducci MA, Eisenberger MA

Rapid disease progression after the administration of bicalutamide in patients with metastatic prostate cancer.

Urology. 1999 Oct;54(4):745.

PubMed ID

10754148 [ View in PubMed

]

Abstract

We report 5 patients with advanced metastatic prostate cancer who took bicalutamide 50 mg/day for "second-line" hormonal manipulation and demonstrated a rapid rise in prostate-specific antigen (PSA) shortly after the initiation of bicalutamide. After discontinuation of the drug, PSA levels declined in 4 patients and stabilized in the fifth. In 2 of the patients, the PSA rise was associated with an increase in pain level, which subsided after the treatment was stopped. The timing of the rapid changes in PSA and pain levels suggests a direct effect of bicalutamide. The most probable explanation for this observation is a very early agonist activation of androgen receptor by bicalutamide, similar to the underlying mechanism of the "antiandrogen withdrawal syndrome."

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Bicalutamide	Androgen receptor	Protein	Humans	Yes	Antagonist	Details