Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3.
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Hickey MJ, Deaven LL, Roth GJ
Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3.
FEBS Lett. 1990 Nov 12;274(1-2):189-92.
- PubMed ID
- 2253772 [ View in PubMed]
- Abstract
Overlapping cDNAs encoding human platelet glycoprotein (Gp)IX were cloned from a human erythroleukemia cell lambda gt11 library. The possibly 'full-length' cDNA of 896 base pairs (bp) includes an open reading frame (528 bp), both 5' (222 bp) and 3' (146 bp) noncoding regions, and a poly(A) tail. Translation predicts a signal peptide of 16 amino acids and a mature protein of 160 amino acids that includes a 24 amino acid leucine-rich glycoprotein (LRG) segment. Southern blot analysis suggests the presence of a single copy of the Gp IX gene, and hybridization of Gp IX cDNA to sorted human chromosomes localizes the Gp IX gene to chromosome 3.