Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.

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Uy GL, Rettig MP, Cashen AF

Plerixafor, a CXCR4 antagonist for the mobilization of hematopoietic stem cells.

Expert Opin Biol Ther. 2008 Nov;8(11):1797-804. doi: 10.1517/14712598.8.11.1797 .

PubMed ID

18847313 [ View in PubMed

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Abstract

Stem cells harvested from peripheral blood are the most commonly used graft source in hematopoietic stem cell transplantation. While G-CSF is the most frequently used agent for stem cell mobilization, the use of G-CSF alone results in suboptimal stem cell yields in a significant proportion of patients undergoing autologous transplantation. Plerixafor (AMD3100, Genzyme Corporation) is a bicyclam molecule that antagonizes the binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its cognate receptor CXCR4. Plerixafor results in the rapid and reversible mobilization of hematopoietic stem cells into the peripheral circulation and is synergistic when combined with G-CSF. In clinical studies of autologous stem cell transplantation, the combination of plerixafor and G-CSF allows the collection of large numbers of stem cells in fewer apheresis sessions and can salvage those who fail G-CSF mobilization alone.

DrugBank Data that Cites this Article

Drugs

Plerixafor

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Plerixafor	C-X-C chemokine receptor type 4	Protein	Humans	Yes	Antagonist Inhibitor	Details