Crystal structure of interleukin 8: symbiosis of NMR and crystallography.
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Baldwin ET, Weber IT, St Charles R, Xuan JC, Appella E, Yamada M, Matsushima K, Edwards BF, Clore GM, Gronenborn AM, et al.
Crystal structure of interleukin 8: symbiosis of NMR and crystallography.
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6.
- PubMed ID
- 1988949 [ View in PubMed]
- Abstract
The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.