X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
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Kallen J, Mikol V, Taylor P, Walkinshaw MD
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A.
J Mol Biol. 1998 Oct 23;283(2):435-49.
- PubMed ID
- 9769216 [ View in PubMed]
- Abstract
Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.