Structure and expression of a cloned cDNA for human interleukin-2.
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Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R, Hamuro J
Structure and expression of a cloned cDNA for human interleukin-2.
Nature. 1983 Mar 24-30;302(5906):305-10.
- PubMed ID
- 6403867 [ View in PubMed]
- Abstract
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells.