The secretion of IL-1beta and options for release.
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Piccioli P, Rubartelli A
The secretion of IL-1beta and options for release.
Semin Immunol. 2013 Dec 15;25(6):425-9. doi: 10.1016/j.smim.2013.10.007. Epub 2013 Nov 5.
- PubMed ID
- 24201029 [ View in PubMed]
- Abstract
Unlike most cytokines, IL-1beta lacks a secretory signal sequence raising the question of how is this cytokine processed and delivered outside the producing cells. After the seminal observation that IL-1beta is actively secreted by human monocytes through a route alternative to the classic endoplasmic reticulum-Golgi, several different pathways have been proposed for IL-1beta secretion in different cell types and culture conditions, some of which are unique to macrophage cell lines. Here we describe the most credited of these pathways. In particular, we will focus on IL-1beta secretion from primary human blood monocytes. In fact, although data from macrophages or macrophage cell lines are predominant, secretion of IL-1beta by monocytes is the most clinically relevant.