Cefroxadine (CGP-9000), an orally active cephalosporin.
Article Details
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Yasuda K, Kurashige S, Mitsuhashi S
Cefroxadine (CGP-9000), an orally active cephalosporin.
Antimicrob Agents Chemother. 1980 Jul;18(1):105-10.
- PubMed ID
- 6998373 [ View in PubMed]
- Abstract
Cefroxadine (GCP-9000; CXD), 7 beta[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-ceph-3-em-carboxylic acid, is a new orally active cephalosporin derivative. The spectrum of antibacterial activity of CXD is identical with that of cephalexin (CEX), but CXD was twofold more effective than CEX against Escherichia coli and Klebsiella pneumoniae, CXD was as stable to penicillinase as CEX, but it was hydrolyzed by cephalosporinase, with a relative rate of hydrolysis similar to that of CEX. The affinities of CXD and CEX to penicillin-binding proteins of E. coli were estimated; the affinity of CXD to penicillin-binding protein 1Bs was higher than that of CEX. Consistent with this, CXD had more intensive lytic activity than CEX. In vivo antibacterial activities of CXD and CEX were compared using systemic infections of mice with E. coli and K. pneumoniae; CXD was consistently more active than CEX.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cefroxadine Penicillin-binding protein 1B Protein Escherichia coli (strain K12) YesInhibitorDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Cefroxadine Beta-lactamase Protein Staphylococcus aureus NoSubstrateDetails