Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.
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Kato N, Lan KH, Ono-Nita SK, Shiratori Y, Omata M
Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.
J Virol. 1997 Nov;71(11):8856-9.
- PubMed ID
- 9343247 [ View in PubMed]
- Abstract
The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.