Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.
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Hui Bon Hoa G, Di Primo C, Dondaine I, Sligar SG, Gunsalus IC, Douzou P
Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.
Biochemistry. 1989 Jan 24;28(2):651-6.
- PubMed ID
- 2578028 [ View in PubMed]
- Abstract
Absorbance and fluorescence spectra of bacterial cytochrome P-450cam and cytochrome P-450lin have been studied as a function of pressure. These pressure-induced spectral perturbations fall into two categories, which are interpreted as resulting from denaturation domains and are discussed in terms of protein structural dynamics. The results presented herein support a view that these two bacterial cytochromes have large structural differences and suggest a picture in which the gellike cortex of each protein may play an essential role in stability and function.