Pharmacokinetics of florfenicol in veal calves.

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Varma KJ, Adams PE, Powers TE, Powers JD, Lamendola JF

Pharmacokinetics of florfenicol in veal calves.

J Vet Pharmacol Ther. 1986 Dec;9(4):412-25.

PubMed ID
3806782 [ View in PubMed
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Abstract

The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22-mg/kg dose intravenously, orally after a 12-h fast and orally 5 min post feeding. Both serum concentrations and urinary excretion were studied. After intravenous administration the median elimination half-life was 171.9 min while the half-life of the distribution phase was 5.9 min. The median body clearance (Cl) and apparent volume of distribution (Vz) were 2.85 ml/kg/min and 0.78 l/kg, respectively. Following oral administration the median bio-availability (f) was 0.88 for calves dosed after a 12-h fast and 0.65 for calves dosed 5 min post feeding. Calves given the oral doses had a complex absorption pattern with delayed absorption. Slightly more than 50% of the administered dose both orally and intravenously was recovered as unchanged florfenicol in the urine by 30 h.

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