Canine ovarian fibroma associated with prolonged exposure to mibolerone.

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Seaman WJ

Canine ovarian fibroma associated with prolonged exposure to mibolerone.

Toxicol Pathol. 1985;13(3):177-80.

PubMed ID
4070927 [ View in PubMed
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Abstract

A study to determine the efficacy and safety of mibolerone following prolonged oral administration in the female dog was terminated after 9.6 yr. Histopathologic examination revealed the presence of small dense tumors in the ovaries of 12 of 92 dogs given mibolerone at the approximate efficacious dose. No such tumors were found in 60 vehicle control animals or 55 animals given exaggerated doses of mibolerone. The tumors were composed of dense fibrous connective tissue and incorporated occasional ovarian medullary tubules. The tumors appeared to grow by expansion with no evidence of invasion or metastasis and were diagnosed as fibromas.

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