Structure of the receptor binding fragment HC of tetanus neurotoxin.
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Umland TC, Wingert LM, Swaminathan S, Furey WF, Schmidt JJ, Sax M
Structure of the receptor binding fragment HC of tetanus neurotoxin.
Nat Struct Biol. 1997 Oct;4(10):788-92.
- PubMed ID
- 9334741 [ View in PubMed]
- Abstract
The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.