Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

Article Details

Citation

Ziegler SF, Marth JD, Lewis DB, Perlmutter RM

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

Mol Cell Biol. 1987 Jun;7(6):2276-85.

PubMed ID
3453117 [ View in PubMed
]
Abstract

Protein-tyrosine kinases are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes and as components of growth factor receptors. Here we report the characterization of a novel human protein-tyrosine kinase gene (hck) that is primarily expressed in hematopoietic cells, particularly granulocytes. The hck gene encodes a 505-residue polypeptide that is closely related to pp56lck, a lymphocyte-specific protein-tyrosine kinase. The exon breakpoints of the hck gene, partially defined by using murine genomic clones, demonstrate that hck is a member of the src gene family and has been subjected to strong selection pressure during mammalian evolution. High-level expression of hck transcripts in granulocytes is especially provocative since these cells are terminally differentiated and typically survive in vivo for only a few hours. Thus the hck gene, like other members of the src gene family, appears to function primarily in cells with little growth potential.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tyrosine-protein kinase HCKP08631Details