PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.
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Armstrong CG, Browne GJ, Cohen P, Cohen PT
PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.
FEBS Lett. 1997 Nov 24;418(1-2):210-4.
- PubMed ID
- 9414128 [ View in PubMed]
- Abstract
A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31% identical to the glycogen-targetting subunit (G(L)) of PP1 from rat liver, 28% identical to the N-terminal region of the glycogen-targetting subunit (G(M)) from human skeletal muscle and 27% identical to glycogen-targetting subunit PPP1R5. Unlike human PPP1R5 and its murine homologue PTG, whose mRNAs are most abundant in skeletal muscle, heart and liver, PPP1R6 is present at similar levels in a wide variety of tissues. The PPP1R6 is associated with glycogen in muscle but is not subject to the same modes of covalent and allosteric regulation as G(M) and G(L).