Anion recognition by thiostrepton.

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Godoy-Alcantar C, Rivera IL, Yatsimirsky AK

Anion recognition by thiostrepton.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):651-4.

PubMed ID
11266162 [ View in PubMed
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Abstract

A bicyclic polypeptide antibiotic thiostrepton forms both 1:1 and 1:2 complexes with anions (as tetrabutylammonium salts) in organic solvents with K2 >K1 for F- and K2<>Cl-, Br-, HSO4-, H2PO4-, but in CHCl3 they follow a different order: Cl- approximatelyHSO4- >F- approximately AcO- > Br > H2PO4-. The binding mode of anions to thiostrepton is discussed on the basis of solvent effects on the complexation selectivity.

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