Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine.
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Watanabe H, Hastings JW
Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine.
Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34.
- PubMed ID
- 2372557 [ View in PubMed]
- Abstract
In bioluminescent bacteria very few agents have been reported that can selectively inhibit the luminescence. In sensitivity tests with Photobacterium phosphoreum, using 55 different antibiotics, it was found that sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth. Likewise, in mutants requiring thymine for growth, the luminescence per cell was much less in a medium low in thymine. In neither case could the decreased specific luminescence be attributed to a decrease in the cellular level of luciferase or aldehyde factor; the involvement of additional but unidentified factors in the regulation of in vivo bioluminescence is postulated.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Sulfamethizole Dihydropteroate synthase Protein Escherichia coli (strain K12) YesInhibitorDetails