Genome organization and transactivation of the human immunodeficiency virus type 2.
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Guyader M, Emerman M, Sonigo P, Clavel F, Montagnier L, Alizon M
Genome organization and transactivation of the human immunodeficiency virus type 2.
Nature. 1987 Apr 16-22;326(6114):662-9.
- PubMed ID
- 3031510 [ View in PubMed]
- Abstract
Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of limited sequence homology; this may help the determination of the structure-function relationships of the different viral elements.