Double bond isomers of cloprostenol.

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Bowler J, Brown ED, Crossley NS, Heaton DW, Lilley TJ, Rose N

Double bond isomers of cloprostenol.

Prostaglandins. 1979 Jun;17(6):789-800.

PubMed ID
504688 [ View in PubMed
]
Abstract

The syntheses of five compounds isomeric with the potent luteolytic agent cloprostenol are described. These are the trans-delta 5, cis and trans-delta 4, cis-delta 6 (methyl ester) and cis-delta 13 analogues. The cis-delta 4 isomer is as potent as cloprostenol as a luteolytic agent in hamsters but the others are markedly less so.

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