Structural basis of the allosteric behaviour of phosphofructokinase.
Article Details
- CitationCopy to clipboard
Schirmer T, Evans PR
Structural basis of the allosteric behaviour of phosphofructokinase.
Nature. 1990 Jan 11;343(6254):140-5.
- PubMed ID
- 2136935 [ View in PubMed]
- Abstract
Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.