Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein.
Article Details
- CitationCopy to clipboard
Oxvig C, Gleich GJ, Sottrup-Jensen L
Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein.
FEBS Lett. 1994 Mar 21;341(2-3):213-7.
- PubMed ID
- 8137941 [ View in PubMed]
- Abstract
Eosinophil granule major basic protein (117 residues) is known to contain free sulfhydryl groups. Here we have located in the amino acid sequence the half-cystine residues present as cysteine, and identified those engaged in disulfide bridges. Of the 9 half-cystine residues, 5 are unpaired cysteines (Cys2, Cys23, Cys42, Cys64, and Cys96), while 4 form disulfides (Cys20-Cys115, and Cys92-Cys107).