A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells.
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Yan X, Poelstra K, Scherphof GL, Kamps JA
A role for scavenger receptor B-I in selective transfer of rhodamine-PE from liposomes to cells.
Biochem Biophys Res Commun. 2004 Dec 17;325(3):908-14.
- PubMed ID
- 15541376 [ View in PubMed]
- Abstract
We investigated the potential role of scavenger receptor B-I (SR-BI) in the selective removal of liposomal markers from blood by hepatocytes. Liposomes were labeled with [(3)H]cholesteryloleyl-ether ([(3)H]COE), 1,2-di[1-(14)C]palmitoyl-phosphatidylcholine ([(14)C]PC), and N-(lissamine rhodamine-B sulfonyl)-phosphatidylethanolamine (N-Rh-PE). The radiolabels were eliminated at identical rates from plasma, while N-Rh-PE was cleared twice as fast. Involvement of SR-BI in the selective removal of N-Rh-PE from liposomes was studied in transfected Chinese hamster ovary cells over-expressing SR-BI. Uptake of N-Rh-PE from liposomes containing phosphatidylserine was higher than [(3)H]COE, and was further enhanced by apolipoprotein A-I, confirming involvement of SR-BI in the selective uptake of liposomal N-Rh-PE by cells.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Phosphatidyl serine Scavenger receptor class B member 1 Protein Humans UnknownNot Available Details