Adenylate cyclase
Details
- Name
- Adenylate cyclase
- Synonyms
- EC 4.6.1.1
- Gene Name
- cyaC
- Organism
- Arthrospira platensis
- Amino acid sequence
>lcl|BSEQ0011927|Adenylate cyclase MSSPNRKLKPTILVVDDEPDNLDLLYRTFHREFKVLKAESGPAALKILEEVGEVAVIISD QRMPYMSGTEFLSLTATQYPDSIRIILTGYTDVEDLVEAINSGKVFKYVTKPWKSDELKA IVQQGLETHNVLKSRTEELRLAQKQESLLYEVTSTIRACPNSQEMLQRIVETVGKMFEVS YCLLRSFGVGSDLIGLGAGVSPTKQDITATQGKEWFAYLAEGQNHQNSTTDNISVINNND LELRSLVWETTEVMILSEGLGNDISDHDGPEWQQRRDVYQRADIRSSLIVPLYYRQELLA VLALHHTGSPRNWHEHEVQLAAGVADQAALALSQVRAYEQVRELARREALVNTITNAIRS SLDPQKIFAAITEQLGEALEVDGCALSLWSPGDEYMQCVGLYNAAIKETVVETRPAALSE PDTSTTTNLPLLGVETNQSIESDQSDDLPQSAAPISGNPVLQELIRTRAPVAIADIEQRP DSMVMLPLRSPSKALLVVPLLLDGDIIGSISLRQNHQVRHWQPSEIDMVLLVAAQAALAV QQARLYQKTRQQAERLLEADRLKTEFFQNVSHEFRTPLTLMIGPLETVVNQQQDLSLDQA KIALRNSRRLLRLVNQLLDLQRFDAGRMQPSFRPCDLVEFCQQTVESFKSYCDRKQINLV TNLQSCPQLYLDLERFDKVLYNLLSNAMKFTPTDGTITVSLQPEGNYCRLMVKDTGIGIK QEQLPHLFERFRQAEGSANRSFEGSGLGLALVKELVELHHGRITVESEYGQGTTFTVWLQ MGNLHLPPSPLLDVPAEFDARRAAVELADVEVDLPDVQIDDINLPEVLVADGSASLTDHG QLGSNTVLVVDDNPDLRRYVSMMLQNAGFNAVLAKNGADGFNKAQTYHPDVIVTDLMMPQ VSGLELIRMIRSSPELRGTPIILLTAKADEDTRIEGVERGADAYVSKPFNDRELIAEVRN LQALKAEERRVAHLNKYLTESVLRRFLPESMVKKAAAGDLTLDLRPEPRLITILFSDIVG FTRMSNALQSQGVAELLNEYLGEMTRAVFENQGTVDKFVGDAIMALYGAPEEMSPSEQVR RAIATARQMLVALEKLNQGWQERGLVGRNEVPPVRFRCGIHQGMAVVGLFGSQERSDFTA IGPSVNIAARLQEATAPNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNML NQ
- Number of residues
- 1202
- Molecular Weight
- 133922.415
- Theoretical pI
- 4.74
- GO Classification
- Functionsadenylate cyclase activity / metal ion binding / phosphorelay sensor kinase activityProcessesprotein-chromophore linkageComponentsintracellular
- General Function
- Phosphorelay sensor kinase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0005357|3609 bp ATGAGTTCCCCCAACAGAAAATTGAAGCCCACCATATTAGTGGTTGATGATGAGCCAGAT AATTTAGATCTGCTATACCGGACTTTCCATCGGGAATTTAAAGTTCTCAAAGCCGAAAGT GGGCCGGCTGCATTGAAGATCTTAGAAGAGGTGGGGGAAGTAGCAGTAATTATCTCTGAT CAGCGGATGCCCTATATGAGTGGCACAGAGTTTCTCAGTTTGACCGCGACTCAATATCCC GATTCGATCCGCATTATCCTCACTGGTTATACGGATGTTGAAGACCTGGTAGAGGCAATT AACTCCGGTAAGGTGTTTAAATATGTCACTAAACCTTGGAAATCTGATGAACTCAAGGCG ATCGTTCAGCAAGGTTTAGAAACTCATAATGTCCTGAAATCTCGCACAGAGGAACTACGC CTAGCACAAAAACAGGAATCGTTACTTTATGAAGTGACAAGTACCATTCGCGCCTGTCCT AATTCCCAGGAAATGTTGCAGCGCATAGTTGAAACAGTGGGTAAAATGTTTGAGGTGAGC TATTGTCTGCTGCGTTCATTCGGTGTGGGTTCAGACCTGATAGGGCTGGGGGCTGGAGTC AGCCCTACCAAACAGGATATCACTGCTACACAAGGGAAGGAGTGGTTCGCATACTTAGCG GAAGGTCAGAATCATCAAAATTCCACGACAGACAACATCAGCGTTATCAATAATAATGAT CTGGAATTGAGATCCCTGGTTTGGGAAACTACGGAAGTAATGATTCTTTCGGAAGGTTTG GGAAATGATATTTCTGACCACGATGGACCAGAATGGCAGCAGCGACGAGACGTTTACCAA CGTGCAGATATTCGCTCCAGTTTGATAGTGCCTCTGTATTACCGTCAGGAATTGTTGGCG GTTTTGGCGCTGCACCACACGGGATCGCCCCGTAATTGGCATGAACATGAAGTGCAGTTA GCTGCGGGTGTAGCAGATCAGGCGGCTTTGGCATTGTCTCAGGTGCGCGCATACGAGCAG GTGCGAGAATTGGCTCGTAGGGAAGCGCTGGTTAATACGATTACCAATGCTATTCGGTCT AGTCTTGACCCTCAGAAAATTTTTGCGGCTATCACTGAGCAATTGGGGGAGGCTTTGGAG GTTGATGGCTGTGCTTTGTCTCTCTGGAGTCCGGGAGATGAATATATGCAGTGTGTAGGC CTTTATAATGCGGCGATTAAAGAAACAGTAGTAGAGACTAGACCGGCGGCTTTGTCTGAA CCTGATACCAGCACGACGACGAATTTGCCCCTATTGGGGGTAGAAACTAATCAATCCATT GAGTCCGATCAGTCCGATGATTTGCCTCAGTCGGCGGCTCCTATTAGTGGCAACCCGGTG CTTCAGGAATTGATTAGAACTCGCGCTCCGGTGGCGATCGCTGATATCGAACAGCGACCA GACTCGATGGTGATGTTGCCTTTGCGATCGCCTTCTAAGGCTCTATTGGTTGTGCCACTA TTGCTCGATGGTGATATTATTGGCAGCATATCCCTACGCCAAAATCACCAAGTTCGCCAT TGGCAACCCTCCGAAATTGATATGGTCCTGTTGGTGGCAGCCCAAGCCGCTTTGGCGGTA CAGCAGGCTCGTCTATACCAAAAAACACGCCAGCAAGCAGAACGCCTATTAGAAGCCGAC CGCCTCAAAACTGAGTTTTTTCAAAATGTCTCCCACGAGTTTCGCACCCCTTTGACTTTG ATGATAGGTCCTTTGGAAACGGTGGTTAATCAACAGCAGGATCTGTCATTAGACCAAGCG AAAATTGCTCTGCGTAACTCCAGGCGACTATTGCGCTTGGTTAATCAATTATTGGATTTG CAACGGTTTGATGCGGGACGAATGCAGCCCAGTTTTCGCCCCTGTGACCTGGTGGAGTTT TGTCAGCAAACGGTGGAATCATTTAAGTCTTATTGCGATCGCAAACAAATTAATCTAGTT ACCAATTTACAGAGTTGCCCCCAACTTTATCTTGATCTGGAAAGGTTTGATAAAGTCCTT TACAATTTGCTCTCTAATGCCATGAAGTTTACCCCCACCGATGGCACTATTACCGTTAGT CTCCAGCCCGAAGGGAATTATTGCCGTCTTATGGTCAAAGATACCGGGATTGGTATTAAA CAAGAACAACTCCCCCATTTATTTGAACGCTTCCGACAAGCTGAAGGTTCAGCCAATCGC TCCTTTGAGGGGAGTGGCTTGGGATTGGCTCTGGTTAAAGAGTTGGTCGAACTCCATCAT GGTCGCATTACTGTAGAGTCTGAGTATGGTCAGGGAACTACATTTACCGTCTGGCTACAA ATGGGGAATCTTCATCTACCACCCTCGCCTCTCCTTGATGTTCCCGCTGAGTTTGATGCA CGTCGAGCAGCCGTAGAATTGGCTGATGTGGAGGTCGATTTACCAGATGTACAAATTGAC GACATAAATCTGCCGGAGGTTTTGGTTGCTGACGGTTCGGCTTCCCTCACGGACCACGGA CAGTTGGGGTCTAATACTGTCCTGGTGGTGGATGATAACCCCGATTTGCGCCGCTATGTG TCGATGATGTTGCAAAATGCCGGATTTAATGCGGTTTTGGCTAAGAATGGCGCTGATGGT TTTAACAAGGCTCAGACTTATCATCCTGATGTGATTGTTACTGATTTGATGATGCCCCAG GTGTCTGGGTTGGAGTTGATTCGCATGATTCGCTCCTCACCTGAACTTAGGGGAACTCCA ATTATTTTGTTGACTGCTAAGGCTGATGAGGATACCCGCATCGAAGGGGTTGAGCGCGGC GCTGATGCCTATGTTTCTAAGCCTTTTAATGACCGGGAGTTGATAGCTGAGGTCAGGAAT TTACAGGCCCTCAAGGCAGAGGAACGACGGGTAGCCCATTTGAATAAGTATCTGACTGAA TCAGTATTGCGACGGTTTTTGCCGGAGTCTATGGTCAAAAAGGCGGCGGCGGGGGACTTG ACTCTGGATTTGCGCCCGGAACCGAGGCTGATTACCATTTTATTTAGTGATATTGTCGGT TTTACTCGGATGTCTAATGCTCTACAGTCTCAGGGGGTGGCGGAATTGCTTAATGAGTAT TTGGGAGAAATGACTCGGGCGGTTTTTGAGAATCAGGGGACTGTTGACAAGTTTGTAGGA GATGCGATTATGGCTTTGTATGGAGCCCCGGAGGAGATGAGCCCCTCTGAACAAGTCCGA CGCGCGATCGCTACGGCTAGACAAATGTTGGTGGCTCTCGAAAAACTTAACCAGGGTTGG CAGGAACGAGGTTTGGTGGGCCGTAATGAGGTTCCTCCGGTGCGGTTCCGCTGTGGGATT CACCAGGGTATGGCTGTGGTGGGGTTGTTTGGTTCCCAAGAGCGATCGGATTTTACGGCG ATCGGTCCTTCGGTTAATATTGCTGCCCGTCTTCAGGAGGCTACTGCCCCCAACAGCATT ATGGTATCCGCTATGGTGGCTCAGTATGTCCCCGATGAGGAGATTATTAAGCGCGAATTT CTCGAACTTAAAGGCATTGATGAGCCGGTAATGACTTGTGTGATTAACCCAAATATGCTG AATCAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O32393 UniProtKB Entry Name O32393_ARTPT GenBank Gene ID D49692 - General References
- Steegborn C, Litvin TN, Hess KC, Capper AB, Taussig R, Buck J, Levin LR, Wu H: A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem. 2005 Sep 9;280(36):31754-9. Epub 2005 Jul 7. [Article]
- Steegborn C, Litvin TN, Levin LR, Buck J, Wu H: Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol. 2005 Jan;12(1):32-7. Epub 2004 Dec 26. [Article]