DNA polymerase catalytic subunit
Details
- Name
- DNA polymerase catalytic subunit
- Synonyms
- 2.7.7.7
- Gene Name
- Not Available
- Organism
- HHV-4
- Amino acid sequence
>lcl|BSEQ0011688|DNA polymerase catalytic subunit MSGGLFYNPFLRPNKGLLKKPDKEYLRLIPKCFQTPGAAGVVDVRGPQPPLCFYQDSLTV VGGDEDGKGMWWRQRAQEGTARPEADTHGSPLDFHVYDILETVYTHEKCAVIPSDKQGYV VPCGIVIKLLGRRKADGASVCVNVFGQQAYFYASAPQGLDVEFAVLSALKASTFDRRTPC RVSVEKVTRRSIMGYGNHAGDYHKITLSHPNSVCHVATWLQDKHGCRIFEANVDATRRFV LDNDFVTFGWYSCRRAIPRLQHRDSYAELEYDCEVGDLSVRREDSSWPSYQALAFDIECL GEEGFPTATNEADLILQISCVLWSTGEEAGRYRRILLTLGTCEDIEGVEVYEFPSELDML YAFFQLIRDLSVEIVTGYNVANFDWPYILDRARHIYSINPASLGKIRAGGVCEVRRPHDA GKGFLRANTKVRITGLIPIDMYAVCRDKLSLSDYKLDTVARHLLGAKKEDVHYKEIPRLF AAGPEGRRRLGMYCVQDSALVMDLLNHFVIHVEVAEIAKIAHIPCRRVLDDGQQIRVFSC LLAAAQKENFILPMPSASDRDGYQGATVIQPLSGFYNSPVLVVDFASLYPSIIQAHNLCY STMITPGEEHRLAGLRPGEDYESFRLTGGVYHFVKKHVHESFLASLLTSWLAKRKAIKKL LAACEDPRQRTILDKQQLAIKCTCNAVYGFTGVANGLFPCLSIAETVTLQGRTMLERAKA FVEALSPANLQALAPSPDAWAPLNPEGQLRVIYGDTDSLFIECRGFSESETLRFADALAA HTTRSLFVAPISLEAEKTFSCLMLITKKRYVGVLTDGKTLMKGVELVRKTACKFVQTRCR RVLDLVLADARVKEAASLLSHRPFQESFTQGLPVGFLPVIDILNQAYTDLREGRVPMGEL CFSTELSRKLSAYKSTQMPHLAVYQKFVERNEELPQIHDRIQYVFVEPKGGVKGARKTEM AEDPAYAERHGVPVAVDHYFDKLLQGAANILQCLFDNNSGAALSVLQNFTARPPF
- Number of residues
- 1015
- Molecular Weight
- 113417.06
- Theoretical pI
- 7.47
- GO Classification
- Functions3'-5' exonuclease activity / DNA binding / DNA-directed DNA polymerase activity / exonuclease activity / nucleotide bindingProcessesbidirectional double-stranded viral DNA replication / nucleic acid phosphodiester bond hydrolysisComponentshost cell nucleus
- General Function
- Nucleotide binding
- Specific Function
- Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Gene sequence
>lcl|BSEQ0011689|DNA polymerase catalytic subunit ATGTCTGGGGGACTCTTCTATAACCCTTTCCTAAGACCTAATAAAGGCCTTCTGAAAAAG CCTGACAAGGAGTACCTGCGTCTCATTCCCAAGTGTTTCCAGACACCAGGCGCCGCAGGG GTGGTGGATGTGCGGGGGCCTCAGCCCCCCCTGTGCTTCTACCAAGACTCCCTGACGGTG GTGGGGGGTGACGAGGATGGAAAGGGCATGTGGTGGCGCCAGCGTGCCCAAGAGGGCACG GCAAGGCCGGAGGCAGACACCCACGGAAGCCCTCTGGACTTCCATGTCTACGACATACTC GAGACGGTGTACACGCACGAGAAATGCGCCGTCATTCCATCGGATAAACAGGGGTATGTG GTGCCATGTGGCATCGTCATCAAGCTACTGGGCCGGCGCAAGGCCGATGGGGCCAGCGTG TGTGTGAACGTGTTTGGGCAGCAGGCCTACTTCTACGCCAGCGCGCCTCAGGGTCTGGAC GTGGAGTTTGCAGTCCTCAGCGCCCTCAAGGCCAGCACCTTCGACCGCAGGACCCCCTGC CGGGTCTCGGTGGAGAAGGTCACGCGCCGTTCCATTATGGGCTACGGCAACCATGCCGGC GACTACCACAAGATCACCCTCTCCCATCCCAACAGTGTGTGTCACGTGGCCACGTGGCTG CAAGACAAGCACGGGTGTCGGATCTTTGAGGCCAACGTGGATGCCACGCGCCGCTTTGTC CTGGACAATGACTTTGTCACCTTTGGCTGGTACAGCTGCCGCCGCGCCATCCCCCGCCTC CAGCACCGGGACTCGTACGCCGAGCTCGAGTACGACTGTGAGGTGGGCGACCTCTCGGTC CGGCGTGAAGACAGCTCCTGGCCCTCCTACCAGGCCCTGGCCTTCGATATCGAGTGTCTG GGGGAGGAGGGCTTCCCCACGGCCACCAACGAGGCTGACCTGATCCTGCAGATATCCTGC GTCCTCTGGTCGACAGGGGAGGAGGCCGGGCGCTATAGGCGCATCCTGCTGACGCTGGGC ACCTGCGAAGACATAGAGGGGGTTGAGGTCTACGAGTTCCCATCGGAGCTGGACATGCTC TACGCCTTCTTCCAGCTCATCAGAGACCTCAGCGTGGAGATTGTGACCGGCTACAACGTG GCCAACTTTGACTGGCCCTACATTCTGGACAGAGCCAGGCACATCTACAGCATCAACCCA GCCTCTCTGGGCAAAATTAGGGCTGGGGGCGTCTGCGAGGTCAGGCGACCCCATGATGCG GGCAAGGGCTTCTTGCGGGCCAACACCAAGGTCCGCATCACCGGCCTCATCCCCATCGAC ATGTACGCCGTGTGCCGGGACAAGCTCAGCCTCTCAGACTACAAGCTGGACACAGTAGCC AGGCACCTACTGGGGGCCAAGAAGGAGGATGTGCATTACAAGGAGATTCCTCGCCTCTTT GCAGCGGGCCCCGAGGGGCGCAGGCGGCTCGGCATGTACTGCGTGCAGGACTCGGCCCTG GTCATGGATCTGCTAAACCATTTCGTGATCCACGTGGAGGTGGCAGAGATTGCCAAGATC GCTCACATCCCCTGCAGGCGGGTGCTGGACGATGGGCAGCAGATCCGCGTGTTCTCCTGC CTCCTGGCGGCCGCCCAAAAGGAAAACTTTATCCTGCCCATGCCCTCGGCCTCTGACCGG GACGGCTACCAGGGGGCCACCGTCATCCAGCCCCTGTCCGGATTCTACAACTCCCCGGTT CTGGTGGTGGACTTTGCCAGCCTCTACCCGAGCATCATTCAGGCTCATAATCTCTGTTAT TCTACCATGATAACGCCGGGAGAAGAGCACAGGCTAGCCGGCCTGCGCCCGGGAGAAGAC TATGAGTCCTTCAGGCTCACGGGGGGCGTCTACCACTTTGTAAAGAAGCACGTGCACGAG TCCTTCTTGGCTAGTCTGTTGACCTCCTGGCTGGCCAAGCGCAAGGCCATCAAGAAGCTG CTGGCGGCCTGCGAGGATCCGCGCCAAAGGACCATCCTCGACAAGCAGCAGCTGGCCATC AAGTGCACGTGCAACGCCGTCTACGGCTTCACCGGGGTGGCCAACGGCCTCTTTCCCTGC CTCTCCATCGCCGAGACGGTGACGCTGCAGGGCCGCACGATGTTGGAGCGGGCCAAGGCC TTCGTGGAGGCCCTGAGCCCCGCCAACCTGCAGGCCCTGGCCCCCTCCCCGGACGCCTGG GCGCCCCTCAACCCCGAGGGCCAGCTTCGAGTCATCTACGGGGACACGGACTCGCTGTTT ATCGAGTGCCGGGGGTTTTCAGAGAGCGAGACCCTGCGCTTTGCCGATGCCCTGGCCGCC CACACCACCCGGAGCCTGTTTGTGGCCCCCATCTCCCTGGAGGCCGAGAAGACCTTCTCC TGCCTGATGCTGATTACAAAGAAGAGATATGTGGGGGTGCTGACGGACGGCAAGACCCTG ATGAAGGGGGTGGAGCTCGTCCGGAAGACGGCCTGCAAGTTTGTGCAGACACGCTGCCGG CGCGTGCTCGACCTGGTGCTGGCGGATGCCCGGGTAAAGGAGGCGGCCAGCCTCCTCTCC CACCGGCCCTTCCAAGAGTCATTTACACAAGGGCTACCTGTGGGCTTTTTGCCCGTCATT GACATCCTAAACCAGGCCTACACAGACCTCCGTGAAGGCAGGGTCCCCATGGGGGAGCTC TGCTTTTCAACGGAGCTCAGCCGCAAGCTCTCAGCCTACAAGAGCACCCAGATGCCTCAC CTGGCCGTCTACCAGAAGTTCGTCGAGCGCAACGAGGAACTGCCCCAGATCCACGACCGC ATCCAGTACGTCTTTGTGGAGCCCAAGGGGGGAGTGAAGGGGGCGAGAAAGACGGAGATG GCCGAGGACCCGGCCTACGCCGAGCGGCACGGCGTTCCCGTGGCCGTGGATCATTATTTC GACAAGCTGCTCCAAGGAGCGGCCAACATCCTCCAGTGCCTCTTTGATAACAACTCCGGG GCCGCCCTCTCCGTCCTCCAGAATTTTACAGCCCGGCCACCATTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P03198 UniProtKB Entry Name DPOL_EBVB9 GenBank Protein ID 1334913 GenBank Gene ID V01555 - General References
- Bankier AT, Deininger PL, Farrell PJ, Barrell BG: Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus. Mol Biol Med. 1983 Jul;1(1):21-45. [Article]
- Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, et al.: DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature. 1984 Jul 19-25;310(5974):207-11. [Article]
- Zeng Y, Middeldorp J, Madjar JJ, Ooka T: A major DNA binding protein encoded by BALF2 open reading frame of Epstein-Barr virus (EBV) forms a complex with other EBV DNA-binding proteins: DNAase, EA-D, and DNA polymerase. Virology. 1997 Dec 22;239(2):285-95. [Article]
- Fujii K, Yokoyama N, Kiyono T, Kuzushima K, Homma M, Nishiyama Y, Fujita M, Tsurumi T: The Epstein-Barr virus pol catalytic subunit physically interacts with the BBLF4-BSLF1-BBLF2/3 complex. J Virol. 2000 Mar;74(6):2550-7. [Article]
- Daikoku T, Kudoh A, Fujita M, Sugaya Y, Isomura H, Shirata N, Tsurumi T: Architecture of replication compartments formed during Epstein-Barr virus lytic replication. J Virol. 2005 Mar;79(6):3409-18. [Article]
- Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L: A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002 Oct;3(10):940-3. Epub 2002 Sep 3. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details