Zinc finger Y-chromosomal protein

Details

Name
Zinc finger Y-chromosomal protein
Synonyms
Not Available
Gene Name
ZFY
Organism
Humans
Amino acid sequence
>lcl|BSEQ0005565|Zinc finger Y-chromosomal protein
MDEDEFELQPQEPNSFFDGIGADATHMDGDQIVVEIQEAVFVSNIVDSDITVHNFVPDDP
DSVVIQDVVEDVVIEEDVQCSDILEEADVSENVIIPEQVLDSDVTEEVSLPHCTVPDDVL
ASDITSTSMSMPEHVLTSESMHVCDIGHVEHMVHDSVVEAEIITDPLTSDIVSEEVLVAD
CAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKIEHDGSTGVTIDAESEMDPCKVD
STCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVN
DSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAAAAAAVHEQQIDEDEMKTFVPIAWAAAY
GNNSDGIENRNGTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQTAIIIGPDGHPLTV
YPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTNKKISLHNHLESHKLTSKA
EKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSK
NFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHIKTKHSKEMP
FKCDICLLTFSDTKEVQQHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKC
EMCEKGFHRPSELKKHVAVHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKDLPFRCKRC
RKGFRQQNELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIHTKDYPHRCEYCKKG
FRRPSEKNQHIMRHHKEVGLP
Number of residues
801
Molecular Weight
90504.29
Theoretical pI
5.99
GO Classification
Functions
metal ion binding / RNA polymerase II regulatory region sequence-specific DNA binding / transcription factor activity, sequence-specific DNA binding
Processes
multicellular organismal development / regulation of transcription, DNA-templated / transcription, DNA-templated
Components
nucleoplasm
General Function
Transcription factor activity, sequence-specific dna binding
Specific Function
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019337|Zinc finger Y-chromosomal protein (ZFY)
ATGGATGGTGATCAGATTGTTGTGGAAATACAAGAAGCAGTTTTTGTTTCTAATATTGTG
GATTCTGACATAACTGTGCATAACTTTGTTCCTGATGACCCAGACTCAGTTGTAATCCAA
GATGTTGTTGAAGATGTTGTCATAGAGGAGGATGTTCAGTGCTCAGATATCTTAGAAGAG
GCAGATGTATCTGAAAATGTCATCATTCCTGAGCAAGTGCTGGACTCAGATGTAACTGAA
GAAGTTTCTTTACCACACTGCACAGTCCCAGATGATGTTTTAGCTTCTGACATTACTTCA
ACCTCAATGTCTATGCCAGAACATGTTTTAACGAGTGAATCCATGCATGTGTGTGACATT
GGACATGTTGAACATATGGTGCATGATAGTGTAGTGGAAGCAGAAATCATTACTGATCCT
CTGACGAGTGACATAGTTTCAGAAGAAGTATTGGTAGCAGACTGTGCCCCTGAAGCAGTC
ATAGATGCCAGCGGGATCTCAGTGGACCAGCAAGATAATGACAAAGCCAGCTGTGAGGAC
TACCTAATGATTTCGTTGGATGATGCTGGCAAAATAGAACATGATGGTTCCACTGGAGTG
ACCATCGATGCAGAATCAGAAATGGATCCTTGTAAAGTGGATAGCACTTGTCCTGAAGTC
ATCAAGGTGTACATTTTTAAAGCTGACCCTGGAGAAGATGACTTAGGTGGAACTGTAGAC
ATTGTGGAGAGTGAACCTGAAAATGATCATGGAGTTGAACTACTTGATCAGAACAGCAGT
ATTCGTGTTCCCAGGGAAAAGATGGTTTATATGACTGTCAATGACTCTCAACAAGAAGAT
GAAGATTTAAGTAATAATTCTGATGGAATTGAAAACCGGAATGGCACTGCAAGTGCCCTC
TTGCACATAGATGAGTCTGCTGGCCTTGGCAGACTGGCTAAACAGAAACCAAAGAAAAAG
AGAAGACCTGATTCCAGGCAGTACCAAACAGCAATAATTATTGGCCCTGATGGTCATCCT
TTGACTGTCTATCCTTGCATGATTTGTGGGAAGAAGTTTAAGTCGAGGGGTTTTTTGAAA
AGACACATGAAAAACCATCCTGAACACCTTGCCAAGAAGAAGTACCACTGTACTGACTGT
GATTACACTACCAATAAGAAGATAAGTTTACATAACCACCTGGAGAGCCACAAGCTGACC
AGCAAGGCAGAGAAGGCCATTGAATGTGATGAGTGTGGGAAGCATTTTTCTCATGCAGGG
GCTTTGTTTACTCACAAAATGGTGCATAAGGAAAAAGGGGCCAACAAAATGCACAAGTGT
AAATTCTGTGAATATGAGACAGCTGAACAGGGGTTATTGAATCGCCACCTCTTGGCAGTC
CACAGCAAGAACTTTCCTCATATTTGTGTGGAGTGTGGTAAAGGTTTCCGACACCCGTCG
GAACTGAGAAAGCACATGCGAATCCATACCGGCGAGAAGCCATACCAATGCCAGTACTGT
GAATATAGGTCTGCAGACTCTTCTAACTTGAAAACACATATAAAAACAAAGCATAGTAAA
GAGATGCCATTCAAGTGTGACATTTGTCTTCTGACTTTCTCAGATACCAAAGAAGTGCAG
CAACATACTCTTGTCCACCAAGAAAGCAAAACACATCAGTGTTTGCATTGCGACCACAAG
AGTTCAAACTCAAGTGATTTGAAACGACATGTAATTTCAGTTCATACGAAAGACTATCCT
CATAAGTGTGAGATGTGCGAGAAAGGCTTTCACAGGCCTTCAGAACTTAAGAAACATGTG
GCTGTCCACAAAGGTAAAAAAATGCACCAATGTAGACATTGTGACTTTAAGATTGCAGAC
CCATTTGTTCTAAGTCGCCATATTCTCTCAGTTCACACAAAGGATCTTCCATTTAGGTGT
AAGAGATGTAGAAAGGGATTTAGGCAACAAAATGAGCTTAAAAAGCATATGAAGACACAC
AGTGGCAGGAAAGTATATCAGTGTGAGTACTGTGAGTATAGCACTACAGATGCCTCAGGC
TTTAAACGGCACGTTATTTCCATTCATACAAAAGACTATCCTCATCGGTGTGAGTACTGC
AAGAAAGGCTTCCGAAGACCTTCAGAAAAGAACCAGCACATAATGAGACACCATAAAGAA
GTTGGTCTGCCCTAA
Chromosome Location
Y
Locus
Yp11.3
External Identifiers
ResourceLink
UniProtKB IDP08048
UniProtKB Entry NameZFY_HUMAN
GenBank Gene IDL10393
GenAtlas IDZFY
HGNC IDHGNC:12870
General References
  1. Lau YF, Chan KM: The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am J Hum Genet. 1989 Dec;45(6):942-52. [Article]
  2. Palmer MS, Berta P, Sinclair AH, Pym B, Goodfellow PN: Comparison of human ZFY and ZFX transcripts. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1681-5. [Article]
  3. Erlandsson R, Wilson JF, Paabo S: Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. Mol Biol Evol. 2000 May;17(5):804-12. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003 Jun 19;423(6942):825-37. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG: The sex-determining region of the human Y chromosome encodes a finger protein. Cell. 1987 Dec 24;51(6):1091-104. [Article]
  8. North M, Sargent C, O'Brien J, Taylor K, Wolfe J, Affara NA, Ferguson-Smith MA: Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. Nucleic Acids Res. 1991 May 25;19(10):2579-86. [Article]
  9. Affara NA, Chambers D, O'Brien J, Habeebu SS, Kalaitsidaki M, Bishop CE, Ferguson-Smith MA: Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9. Nucleic Acids Res. 1989 Apr 25;17(8):2987-99. [Article]
  10. Grants J, Flanagan E, Yee A, Romaniuk PJ: Characterization of the DNA binding activity of the ZFY zinc finger domain. Biochemistry. 2010 Feb 2;49(4):679-86. doi: 10.1021/bi9018626. [Article]
  11. Kochoyan M, Havel TF, Nguyen DT, Dahl CE, Keutmann HT, Weiss MA: Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition. Biochemistry. 1991 Apr 9;30(14):3371-86. [Article]
  12. Kochoyan M, Keutmann HT, Weiss MA: Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition. Biochemistry. 1991 Jul 23;30(29):7063-72. [Article]
  13. Lachenmann MJ, Ladbury JE, Qian X, Huang K, Singh R, Weiss MA: Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice. Protein Sci. 2004 Dec;13(12):3115-26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB028843-Cyclohexyl-L-alanineexperimentalunknownDetails
DB05483Picolinic acidinvestigationalunknownDetails