Cyclin-dependent kinase 4
Details
- Name
- Cyclin-dependent kinase 4
- Synonyms
- 2.7.11.22
- Cell division protein kinase 4
- PSK-J3
- Gene Name
- CDK4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004349|Cyclin-dependent kinase 4 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG NPE
- Number of residues
- 303
- Molecular Weight
- 33729.55
- Theoretical pI
- 7.01
- GO Classification
- FunctionsATP binding / cyclin binding / cyclin-dependent protein serine/threonine kinase activity / cyclin-dependent protein serine/threonine kinase regulator activityProcessescell division / chromatin organization / circadian rhythm / G1/S transition of mitotic cell cycle / lens development in camera-type eye / mitotic cell cycle / negative regulation of cell cycle arrest / organ regeneration / positive regulation of apoptotic process / positive regulation of cell proliferation / positive regulation of cell size / positive regulation of fibroblast proliferation / positive regulation of G2/M transition of mitotic cell cycle / positive regulation of translation / protein phosphorylation / regulation of gene expression / regulation of protein kinase activity / response to drug / response to hyperoxia / response to lead ion / response to testosterone / response to toxic substance / signal transductionComponentsbicellular tight junction / chromatin / cyclin-dependent protein kinase holoenzyme complex / cytosol / nuclear membrane / nucleolus / nucleoplasm / nucleus / perinuclear region of cytoplasm / transcription factor complex
- General Function
- Cyclin-dependent protein serine/threonine kinase regulator activity
- Specific Function
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020596|Cyclin-dependent kinase 4 (CDK4) ATGGCTACCTCTCGATATGAGCCAGTGGCTGAAATTGGTGTCGGTGCCTATGGGACAGTG TACAAGGCCCGTGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTGAGAGTCCCC AATGGAGGAGGAGGTGGAGGAGGCCTTCCCATCAGCACAGTTCGTGAGGTGGCTTTACTG AGGCGACTGGAGGCTTTTGAGCATCCCAATGTTGTCCGGCTGATGGACGTCTGTGCCACA TCCCGAACTGACCGGGAGATCAAGGTAACCCTGGTGTTTGAGCATGTAGACCAGGACCTA AGGACATATCTGGACAAGGCACCCCCACCAGGCTTGCCAGCCGAAACGATCAAGGATCTG ATGCGCCAGTTTCTAAGAGGCCTAGATTTCCTTCATGCCAATTGCATCGTTCACCGAGAT CTGAAGCCAGAGAACATTCTGGTGACAAGTGGTGGAACAGTCAAGCTGGCTGACTTTGGC CTGGCCAGAATCTACAGCTACCAGATGGCACTTACACCCGTGGTTGTTACACTCTGGTAC CGAGCTCCCGAAGTTCTTCTGCAGTCCACATATGCAACACCTGTGGACATGTGGAGTGTT GGCTGTATCTTTGCAGAGATGTTTCGTCGAAAGCCTCTCTTCTGTGGAAACTCTGAAGCC GACCAGTTGGGCAAAATCTTTGACCTGATTGGGCTGCCTCCAGAGGATGACTGGCCTCGA GATGTATCCCTGCCCCGTGGAGCCTTTCCCCCCAGAGGGCCCCGCCCAGTGCAGTCGGTG GTACCTGAGATGGAGGAGTCGGGAGCACAGCTGCTGCTGGAAATGCTGACTTTTAACCCA CACAAGCGAATCTCTGCCTTTCGAGCTCTGCAGCACTCTTATCTACATAAGGATGAAGGT AATCCGGAGTGA
- Chromosome Location
- 12
- Locus
- 12q14
- External Identifiers
Resource Link UniProtKB ID P11802 UniProtKB Entry Name CDK4_HUMAN GenBank Protein ID 456427 GenBank Gene ID M14505 GenAtlas ID CDK4 HGNC ID HGNC:1773 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03496 Alvocidib experimental, investigational unknown Details DB02733 Purvalanol experimental unknown Details DB09073 Palbociclib approved, investigational yes inhibitor Details DB11730 Ribociclib approved, investigational yes antagonistinhibitor Details DB12001 Abemaciclib approved, investigational yes inhibitor Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details DB15442 Trilaciclib approved, investigational yes inhibitor Details