Tropomyosin alpha-4 chain
Details
- Name
- Tropomyosin alpha-4 chain
- Synonyms
- TM30p1
- Tropomyosin-4
- Gene Name
- TPM4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049791|Tropomyosin alpha-4 chain MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ TLNELNCI
- Number of residues
- 248
- Molecular Weight
- 28521.535
- Theoretical pI
- Not Available
- GO Classification
- Functionsactin filament binding / calcium ion binding / structural constituent of muscleProcessesactin filament organization / movement of cell or subcellular component / muscle contraction / muscle filament sliding / osteoblast differentiationComponentsactin filament / cortical cytoskeleton / cytoskeleton / cytosol / extracellular exosome / filamentous actin / focal adhesion / membrane / muscle thin filament tropomyosin / podosome / stress fiber
- General Function
- Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
- Specific Function
- Actin filament binding
- Pfam Domain Function
- Tropomyosin (PF00261)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0049792|Tropomyosin alpha-4 chain (TPM4) ATGGCCGGCCTCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAG GCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCGAGCGCGAG CGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAG GAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCA GAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAG GATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAA GAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTG GAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAA CTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAA AAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAG ACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTG GAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAG ACACTAAACGAACTTAACTGTATATAA
- Chromosome Location
- 19
- Locus
- 19p13.12-p13.11
- External Identifiers
Resource Link UniProtKB ID P67936 UniProtKB Entry Name TPM4_HUMAN HGNC ID HGNC:12013 - General References
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