Tropomyosin alpha-4 chain

Details

Name
Tropomyosin alpha-4 chain
Synonyms
  • TM30p1
  • Tropomyosin-4
Gene Name
TPM4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049791|Tropomyosin alpha-4 chain
MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE
EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE
KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ
TLNELNCI
Number of residues
248
Molecular Weight
28521.535
Theoretical pI
Not Available
GO Classification
Functions
actin filament binding / calcium ion binding / structural constituent of muscle
Processes
actin filament organization / movement of cell or subcellular component / muscle contraction / muscle filament sliding / osteoblast differentiation
Components
actin filament / cortical cytoskeleton / cytoskeleton / cytosol / extracellular exosome / filamentous actin / focal adhesion / membrane / muscle thin filament tropomyosin / podosome / stress fiber
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
Specific Function
Actin filament binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049792|Tropomyosin alpha-4 chain (TPM4)
ATGGCCGGCCTCAACTCCCTGGAGGCGGTGAAACGCAAGATCCAGGCCCTGCAGCAGCAG
GCGGACGAGGCGGAAGACCGCGCGCAGGGCCTGCAGCGGGAGCTGGACGGCGAGCGCGAG
CGGCGCGAGAAAGCTGAAGGTGATGTGGCCGCCCTCAACCGACGCATCCAGCTCGTTGAG
GAGGAGTTGGACAGGGCTCAGGAACGACTGGCCACGGCCCTGCAGAAGCTGGAGGAGGCA
GAAAAAGCTGCAGATGAGAGTGAGAGAGGAATGAAGGTGATAGAAAACCGGGCCATGAAG
GATGAGGAGAAGATGGAGATTCAGGAGATGCAGCTCAAAGAGGCCAAGCACATTGCGGAA
GAGGCTGACCGCAAATACGAGGAGGTAGCTCGTAAGCTGGTCATCCTGGAGGGTGAGCTG
GAGAGGGCAGAGGAGCGTGCGGAGGTGTCTGAACTAAAATGTGGTGACCTGGAAGAAGAA
CTCAAGAATGTTACTAACAATCTGAAATCTCTGGAGGCTGCATCTGAAAAGTATTCTGAA
AAGGAGGACAAATATGAAGAAGAAATTAAACTTCTGTCTGACAAACTGAAAGAGGCTGAG
ACCCGTGCTGAATTTGCAGAGAGAACGGTTGCAAAACTGGAAAAGACAATTGATGACCTG
GAAGAGAAACTTGCCCAGGCCAAAGAAGAGAACGTGGGCTTACATCAGACACTGGATCAG
ACACTAAACGAACTTAACTGTATATAA
Chromosome Location
19
Locus
19p13.12-p13.11
External Identifiers
ResourceLink
UniProtKB IDP67936
UniProtKB Entry NameTPM4_HUMAN
HGNC IDHGNC:12013
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails