Matrix metalloproteinase-24
Details
- Name
- Matrix metalloproteinase-24
- Synonyms
- 3.4.24.-
- Membrane-type matrix metalloproteinase 5
- Membrane-type-5 matrix metalloproteinase
- MMP-24
- MT-MMP 5
- MT5-MMP
- MT5MMP
- MTMMP5
- Gene Name
- MMP24
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012575|Matrix metalloproteinase-24 MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAG NRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGI PVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVG ELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGG FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR PPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTAL RWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYK GRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSV NAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
- Number of residues
- 645
- Molecular Weight
- 73230.93
- Theoretical pI
- 9.58
- GO Classification
- Functionscalcium ion binding / enzyme activator activity / metalloendopeptidase activity / zinc ion bindingProcessescell-cell adhesion / cell-cell adhesion mediated by cadherin / detection of temperature stimulus involved in sensory perception of pain / glial cell differentiation / neuronal stem cell population maintenance / positive regulation of catalytic activity / proteolysisComponentsextracellular exosome / integral component of plasma membrane / proteinaceous extracellular matrix / trans-Golgi network membrane
- General Function
- Zinc ion binding
- Specific Function
- Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 603-623
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012576|Matrix metalloproteinase-24 (MMP24) ATGCCGAGGAGCCGGGGCGGCCGCGCCGCGCCGGGGCCGCCGCCGCCGCCGCCGCCGCCG GGCCAGGCCCCGCGCTGGAGCCGCTGGCGGGTCCCTGGGCGGCTGCTGCTGCTGCTGCTG CCCGCGCTCTGCTGCCTCCCGGGCGCCGCGCGGGCGGCGGCGGCGGCGGCGGGGGCAGGG AACCGGGCAGCGGTGGCGGTGGCGGTGGCGCGGGCGGACGAGGCGGAGGCGCCCTTCGCC GGGCAGAACTGGTTAAAGTCCTATGGCTATCTGCTTCCCTATGACTCACGGGCATCTGCG CTGCACTCAGCGAAGGCCTTGCAGTCGGCAGTCTCCACTATGCAGCAGTTTTACGGGATC CCGGTCACCGGTGTGTTGGATCAGACAACGATCGAGTGGATGAAGAAACCCCGATGTGGT GTCCCTGATCACCCCCACTTAAGCCGTAGGCGGAGAAACAAGCGCTATGCCCTGACTGGA CAGAAGTGGAGGCAAAAACACATCACCTACAGCATTCACAACTATACCCCAAAAGTGGGT GAGCTAGACACGCGGAAAGCTATTCGCCAGGCTTTCGATGTGTGGCAGAAGGTGACCCCA CTGACCTTTGAAGAGGTGCCATACCATGAGATCAAAAGTGACCGGAAGGAGGCAGACATC ATGATCTTTTTTGCTTCTGGTTTCCATGGCGACAGCTCCCCATTTGATGGAGAAGGGGGA TTCCTGGCCCATGCCTACTTCCCTGGCCCAGGGATTGGAGGAGACACCCACTTTGACTCC GATGAGCCATGGACGCTAGGAAATGCCAACCATGACGGGAACGACCTCTTCCTGGTGGCT GTGCATGAGCTGGGCCACGCGCTGGGACTGGAGCACTCCAGCGACCCCAGCGCCATCATG GCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAG GGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCT ACACTCCCCGTCCGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGG CCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGT GACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGC TGGTTCTGGCGTCTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAG TTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTT GTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTAC CCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTG CGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGC GAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATC CCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAG GGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGC AACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGG CGGCTGCCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTG AACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTAC ACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCA GTCCAGGAATGGGTGTGA
- Chromosome Location
- 20
- Locus
- 20q11.2
- External Identifiers
Resource Link UniProtKB ID Q9Y5R2 UniProtKB Entry Name MMP24_HUMAN GenBank Protein ID 5381386 GenBank Gene ID AF131284 HGNC ID HGNC:7172 - General References
- Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C: Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res. 1999 Jun 1;59(11):2570-6. [Article]
- Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]