Tolloid-like protein 2
Details
- Name
- Tolloid-like protein 2
- Synonyms
- 3.4.24.-
- KIAA0932
- Gene Name
- TLL2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009400|Tolloid-like protein 2 MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAV FWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAG KDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIF KQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIV AHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMH YARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTG NFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAP LLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNY PDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCG YEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYK CACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL QFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV SKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKI SSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGP DSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTK ELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSS APRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK
- Number of residues
- 1015
- Molecular Weight
- 113555.78
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion binding / metalloendopeptidase activity / zinc ion bindingProcessescell differentiation / extracellular matrix disassembly / extracellular matrix organization / multicellular organismal developmentComponentsextracellular region
- General Function
- Zinc ion binding
- Specific Function
- Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0020761|Tolloid-like protein 2 (TLL2) ATGCCCCGGGCGACTGCACTTGGGGCCCTGGTGTCACTGCTGCTGCTGCTGCCGCTGCCT CGCGGCGCCGGGGGACTCGGGGAGCGCCCGGACGCCACCGCAGACTACTCAGAGCTGGAC GGCGAGGAGGGCACGGAGCAGCAGCTGGAGCATTACCACGACCCTTGCAAAGCCGCTGTC TTTTGGGGAGACATTGCCTTAGATGAAGATGACTTGAAGCTGTTTCACATTGACAAAGCC AGAGACTGGACCAAGCAGACAGTGGGGGCAACAGGACACAGCACAGGTGGGCTTGAAGAG CAGGCATCTGAGAGCAGCCCAGACACCACAGCCATGGACACTGGCACCAAGGAAGCTGGA AAGGATGGCCGGGAGAATACCACACTCCTGCACAGCCCTGGGACCTTGCATGCCGCAGCC AAGACCTTCTCTCCCCGGGTCCGAAGAGCCACAACCTCAAGGACAGAGAGGATATGGCCT GGAGGAGTCATCCCCTACGTCATTGGAGGGAACTTCACTGGGAGCCAGAGGGCCATTTTT AAGCAGGCCATGAGACACTGGGAGAAGCACACCTGTGTGACCTTCATAGAAAGGACGGAT GAGGAAAGCTTTATTGTATTCAGTTACAGAACCTGTGGCTGTTGCTCCTATGTTGGGCGC CGAGGAGGAGGCCCACAGGCCATATCCATTGGGAAGAACTGTGACAAGTTTGGCATTGTG GCTCACGAGCTGGGCCATGTGGTTGGGTTTTGGCATGAACACACCCGGCCAGACAGAGAC CAACATGTCACCATCATCAGGGAAAACATCCAGCCAGGTCAGGAGTATAATTTCTTAAAA ATGGAAGCTGGGGAAGTGAGCTCTCTGGGAGAGACATACGACTTTGACAGCATCATGCAC TACGCCCGGAACACCTTCTCAAGAGGAGTTTTCTTAGACACCATCCTTCCCCGTCAAGAT GACAATGGCGTCAGGCCAACCATTGGCCAGCGCGTGCGGCTCAGTCAGGGAGACATAGCT CAAGCCCGGAAGCTGTACAAATGCCCAGCGTGTGGGGAGACCCTGCAGGACACAACGGGA AACTTTTCTGCACCTGGTTTCCCAAATGGGTACCCATCTTACTCCCACTGCGTCTGGAGG ATCTCGGTCACCCCAGGGGAAAAGATCGTATTAAACTTCACATCCATGGATTTGTTTAAA AGCCGACTGTGCTGGTATGATTACGTGGAGGTCCGGGATGGTTACTGGAGAAAAGCCCCC CTTTTGGGCAGGTTTTGTGGCGATAAGATCCCGGAGCCCCTCGTCTCCACGGACAGCCGG CTCTGGGTGGAGTTCCGCAGCAGCAGCAACATCTTGGGCAAGGGCTTCTTTGCAGCGTAC GAAGCTACCTGCGGGGGAGACATGAACAAAGATGCCGGTCAGATTCAATCTCCCAACTAT CCGGATGACTACAGACCTTCCAAGGAATGTGTCTGGAGGATTACGGTTTCAGAGGGGTTT CACGTGGGACTTACCTTCCAAGCTTTTGAGATTGAAAGGCACGACAGCTGTGCATATGAC TACCTGGAAGTCCGGGATGGCCCCACGGAAGAGAGTGCCCTGATCGGCCACTTTTGTGGC TATGAGAAGCCGGAGGATGTGAAATCGAGCTCCAACAGACTGTGGATGAAGTTTGTGTCC GATGGCTCTATCAATAAAGCGGGCTTTGCAGCCAATTTTTTCAAGGAGGTGGATGAGTGT TCCTGGCCAGATCACGGCGGGTGCGAGCATCGCTGTGTGAACACGCTGGGCAGCTACAAG TGTGCCTGTGACCCTGGCTACGAGCTGGCCGCCGATAAGAAGATGTGTGAAGTGGCCTGT GGCGGTTTCATTACCAAGCTGAATGGAACCATCACCAGCCCTGGGTGGCCGAAGGAGTAT CCCACAAACAAAAACTGTGTCTGGCAGGTGGTGGCCCCCGCTCAGTACCGGATCTCCCTT CAGTTTGAAGTGTTTGAACTGGAAGGCAATGACGTCTGTAAGTACGACTTTGTAGAGGTG CGCAGCGGCCTGTCCCCCGACGCCAAGCTGCACGGCAGGTTCTGCGGCTCTGAGACGCCG GAGGTCATCACCTCGCAGAGCAACAACATGCGCGTGGAGTTCAAGTCCGACAACACCGTC TCCAAGCGCGGCTTCAGGGCCCACTTCTTCTCAGATAAGGACGAGTGTGCCAAGGACAAC GGCGGGTGTCAGCATGAGTGCGTCAACACCTTCGGGAGCTACCTGTGCAGGTGCAGAAAC GGCTACTGGCTCCACGAGAATGGGCATGACTGCAAAGAGGCTGGCTGTGCACACAAGATC AGCAGTGTGGAGGGGACCCTGGCGAGCCCCAACTGGCCTGACAAATACCCCAGCCGGAGG GAGTGTACCTGGAACATCTCTTCGACTGCAGGCCACAGAGTGAAACTCACCTTTAATGAG TTTGAGATCGAGCAGCACCAGGAATGTGCCTATGACCACCTGGAAATGTATGACGGGCCG GACAGCCTGGCCCCCATTCTGGGCCGTTTCTGCGGCAGCAAGAAACCAGACCCCACGGTG GCTTCCGGCAGCAGTATGTTTCTCAGGTTTTATTCGGATGCCTCAGTGCAGAGGAAAGGC TTCCAGGCAGTGCACAGCACAGAGTGCGGGGGCAGGCTGAAGGCTGAAGTGCAGACCAAA GAGCTCTATTCCCACGCCCAGTTTGGGGACAACAACTACCCGAGCGAGGCCCGCTGTGAC TGGGTGATCGTGGCAGAGGACGGCTACGGCGTGGAGCTGACATTCCGGACCTTTGAGGTT GAGGAGGAGGCCGACTGCGGCTACGACTACATGGAAGCCTACGACGGCTACGACAGCTCA GCGCCCAGGCTCGGCCGCTTCTGTGGCTCTGGGCCATTAGAAGAAATCTACTCTGCAGGT GATTCCCTGATGATTCGATTCCGCACAGATGACACCATCAACAAGAAAGGCTTTCATGCC CGATACACCAGCACCAAGTTCCAGGATGCCCTGCACATGAAGAAATAG
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Y6L7 UniProtKB Entry Name TLL2_HUMAN HGNC ID HGNC:11844 - General References
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- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Feb 26;6(1):63-70. [Article]
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- Uzel MI, Scott IC, Babakhanlou-Chase H, Palamakumbura AH, Pappano WN, Hong HH, Greenspan DS, Trackman PC: Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. J Biol Chem. 2001 Jun 22;276(25):22537-43. Epub 2001 Apr 19. [Article]