Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors

All categories
Name
Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
Accession Number
DBCAT005753
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
InfigratinibAn FGFR inhibitor used to treat locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) rearrangement.
ErdafitinibA fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma.
PemigatinibA kinase inhibitor used to treat locally advanced or metastatic, unresectable cholangiocarcinoma in previously treated adult patients.
FutibatinibA kinase inhibitor used to treat intrahepatic cholangiocarcinoma in previously treated adults.
Drugs & Drug Targets
DrugTargetType
InfigratinibCytochrome P450 3A4enzyme
InfigratinibMultidrug and toxin extrusion protein 1transporter
InfigratinibATP-binding cassette sub-family G member 2transporter
InfigratinibBile salt export pumptransporter
InfigratinibSolute carrier family 22 member 1transporter
InfigratinibSolute carrier family 22 member 2transporter
InfigratinibMultidrug and toxin extrusion protein 2transporter
InfigratinibP-glycoprotein 1transporter
InfigratinibSolute carrier organic anion transporter family member 1B1transporter
InfigratinibSolute carrier organic anion transporter family member 1B3transporter
InfigratinibApolipoproteinscarrier
InfigratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
InfigratinibFibroblast growth factor receptor 1target
InfigratinibFibroblast growth factor receptor 2target
InfigratinibFibroblast growth factor receptor 3target
InfigratinibFibroblast growth factor receptor 4target
ErdafitinibCytochrome P450 2C9enzyme
ErdafitinibCytochrome P450 3A4enzyme
ErdafitinibFibroblast growth factor receptor 1target
ErdafitinibFibroblast growth factor receptor 2target
ErdafitinibFibroblast growth factor receptor 3target
ErdafitinibFibroblast growth factor receptor 4target
ErdafitinibP-glycoprotein 1transporter
ErdafitinibSolute carrier family 22 member 2transporter
ErdafitinibProto-oncogene tyrosine-protein kinase receptor Rettarget
ErdafitinibMacrophage colony-stimulating factor 1 receptortarget
ErdafitinibPlatelet-derived growth factor receptor alphatarget
ErdafitinibPlatelet-derived growth factor receptor betatarget
ErdafitinibMast/stem cell growth factor receptor Kittarget
ErdafitinibVascular endothelial growth factor receptor 2target
Erdafitinibalpha1-acid glycoproteincarrier
PemigatinibCytochrome P450 3A4enzyme
PemigatinibFibroblast growth factor receptor 1target
PemigatinibFibroblast growth factor receptor 2target
PemigatinibFibroblast growth factor receptor 3target
PemigatinibFibroblast growth factor receptor 4target
PemigatinibP-glycoprotein 1transporter
PemigatinibATP-binding cassette sub-family G member 2transporter
PemigatinibSolute carrier family 22 member 2transporter
PemigatinibMultidrug and toxin extrusion protein 1transporter
FutibatinibCytochrome P450 3A4enzyme
FutibatinibP-glycoprotein 1transporter
FutibatinibATP-binding cassette sub-family G member 2transporter
FutibatinibSerum albumincarrier
FutibatinibAlpha-1-acid glycoprotein 1carrier
FutibatinibCytochrome P450 2C9enzyme
FutibatinibCytochrome P450 2D6enzyme
FutibatinibFibroblast growth factor receptor 1target
FutibatinibFibroblast growth factor receptor 2target
FutibatinibFibroblast growth factor receptor 3target
FutibatinibFibroblast growth factor receptor 4target