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Identification
Name Sermorelin
Accession Number DB00010 (BIOD00033, BTD00033)
Type biotech
Groups approved
Description

Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues
Protein structure No_structure_small
Protein chemical formula C149H246N44O42S
Protein average weight 3357.8820
Sequences 
>DB00010 sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSRQ

FASTA
Synonyms Not Available
Salts Not Available
Brand names
Name Company
Geref Serono Pharma
Brand mixtures Not Available
Categories
  • Anabolic Agents
  • Hormone Replacement Agents
CAS number 86168-78-7
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication For the treatment of dwarfism, prevention of HIV-induced weight loss
Pharmacodynamics Sermorelin is used in the treatment of children with growth hormone deficiency or growth failure. Geref increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Geref is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans.
Mechanism of action Sermorelin binds to the growth hormone releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life 11-12 min
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Pathways Not Available
Pharmacoeconomics
Manufacturers
  • Emd serono inc
Packagers
Dosage forms
Form Route Strength
Injection, powder, lyophilized, for solution Subcutaneous
Prices Not Available
Patents Not Available
Properties
State liquid
Experimental Properties
Property Value Source
hydrophobicity -0.330 Not Available
isoelectric point 9.99 Not Available
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
PharmGKB PA164749110 Link_out
RxList http://www.rxlist.com/cgi/generic2/sermorelin.htm Link_out
Drugs.com http://www.drugs.com/cdi/sermorelin-acetate.html Link_out
Wikipedia http://en.wikipedia.org/wiki/Sermorelin Link_out
ATC Codes
  • H01AC04
  • V04CD03
AHFS Codes Not Available
PDB Entries Not Available
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Searched, but no interactions found.
Food Interactions Not Available
Targets

1. Growth hormone-releasing hormone receptor

Pharmacological action: yes
Actions: agonist

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion

Organism class: human
UniProt ID: Q02643 Link_out
Gene: GHRHR Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Esposito P, Barbero L, Caccia P, Caliceti P, D’Antonio M, Piquet G, Veronese FM: PEGylation of growth hormone-releasing hormone (GRF) analogues. Adv Drug Deliv Rev. 2003 Sep 26;55(10):1279-91. Pubmed
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on September 03, 2011 17:02