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Identification
NameAlfentanil
Accession NumberDB00802  (APRD00726)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. [PubChem]
Structure
Thumb
Synonyms
Alfentanilum
Alfentanyl
N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alfenta Inj 500mcg/mlsolution500 mcgintravenousJanssen Inc1988-12-312008-09-05Canada
Alfentanilinjection500 ug/mLintravenousAkorn, Inc.2013-07-19Not applicableUs
Alfentanil Hydrochlorideinjection500 ug/mLintravenousAkorn, Inc.2010-02-01Not applicableUs
Alfentanil Injection USPsolution500 mcgintravenousSandoz Canada Incorporated2004-11-01Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alfentanil Hydrochlorideinjection, solution500 ug/mLintravenousHospira, Inc.1999-10-28Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
RapifenJanssen
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Alfentanil hydrochloride
ThumbNot applicableDBSALT001202
Categories
UNII1N74HM2BS7
CAS number71195-58-9
WeightAverage: 416.5172
Monoisotopic: 416.25358892
Chemical FormulaC21H32N6O3
InChI KeyInChIKey=IDBPHNDTYPBSNI-UHFFFAOYSA-N
InChI
InChI=1S/C21H32N6O3/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26/h6-10H,4-5,11-17H2,1-3H3
IUPAC Name
N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide
SMILES
CCN1N=NN(CCN2CCC(COC)(CC2)N(C(=O)CC)C2=CC=CC=C2)C1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as anilides. These are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassAnilides
Direct ParentAnilides
Alternative Parents
Substituents
  • Anilide
  • 4-aminopiperidine
  • Piperidine
  • Heteroaromatic compound
  • Tetrazole
  • Tertiary carboxylic acid amide
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the management of postoperative pain and the maintenance of general anesthesia.
PharmacodynamicsAlfentanil is a synthetic opioid analgesic. Alfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, alfentanil exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Alfentanil may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Alfentanil depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Mechanism of actionOpiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Alfentanil's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Related Articles
AbsorptionFor intravenous injection or infusion only.
Volume of distribution
  • 0.4 to 1 L/kg
Protein binding92%
Metabolism

The liver is the major site of biotransformation.

SubstrateEnzymesProduct
Alfentanil
AMXDetails
Alfentanil
noralfentanilDetails
Route of eliminationOnly 1.0% of the dose is excreted as unchanged drug; urinary excretion is the major route of elimination of metabolites.
Half life90-111 minutes
Clearance
  • 5 mL/kg/min
ToxicitySymptoms of overexposure include characteristic rigidity of the skeletal muscles, cardiac and respiratory depression, and narrowing of the pupils.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Alfentanil Action PathwayDrug actionSMP00413
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9957
Blood Brain Barrier+0.9396
Caco-2 permeable-0.5368
P-glycoprotein substrateSubstrate0.7156
P-glycoprotein inhibitor IInhibitor0.8809
P-glycoprotein inhibitor IINon-inhibitor0.8381
Renal organic cation transporterNon-inhibitor0.7077
CYP450 2C9 substrateNon-substrate0.7897
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9067
CYP450 2C9 inhibitorInhibitor0.6051
CYP450 2D6 inhibitorNon-inhibitor0.9003
CYP450 2C19 inhibitorNon-inhibitor0.5591
CYP450 3A4 inhibitorInhibitor0.6691
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6692
Ames testAMES toxic0.5858
CarcinogenicityNon-carcinogens0.7729
BiodegradationNot ready biodegradable0.9877
Rat acute toxicity2.9997 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6413
hERG inhibition (predictor II)Inhibitor0.5893
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Akorn inc
  • Hospira inc
Packagers
Dosage forms
FormRouteStrength
Injectionintravenous500 ug/mL
Injection, solutionintravenous500 ug/mL
Solutionintravenous500 mcg
Prices
Unit descriptionCostUnit
Alfenta 500 mcg/ml ampul5.26USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point140.8Janssens, F.; US. Patent 4,167,574; September 11, 1979; assigned to Janssen Pharmaceutica NV.
water solubility34.6 mg/LNot Available
logP2.16HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.252 mg/mLALOGPS
logP2.2ALOGPS
logP2.81ChemAxon
logS-3.2ALOGPS
pKa (Strongest Basic)7.5ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area81.05 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity118.59 m3·mol-1ChemAxon
Polarizability45.57 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Jacob Mathew, J. Killgore, “New methods for the synthesis of alfentanil, sufentanil, and remifentanil.” U.S. Patent US20060149071, issued July 06, 2006.

US20060149071
General ReferencesNot Available
External Links
ATC CodesN01AH02
AHFS Codes
  • 28:08.08
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (51.3 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Alfentanil.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Alfentanil.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Alfentanil is combined with 7-Nitroindazole.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Alfentanil.
AcepromazineAcepromazine may increase the hypotensive activities of Alfentanil.
AcepromazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Aceprometazine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Alfentanil.
AcetazolamideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Acetazolamide.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Alfentanil.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Alfentanil.
adipiplonThe risk or severity of adverse effects can be increased when Alfentanil is combined with adipiplon.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Alfentanil.
AgomelatineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Agomelatine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Alfentanil.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Alfaxalone.
AlimemazineAlimemazine may increase the hypotensive activities of Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Alfentanil.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Alfentanil.
AlvimopanThe risk or severity of adverse effects can be increased when Alfentanil is combined with Alvimopan.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Alfentanil.
AmilorideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Amiloride.
AmiodaroneThe metabolism of Alfentanil can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Amisulpride.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Alfentanil.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Alfentanil.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Alfentanil which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Amobarbital.
AmoxapineAlfentanil may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Alfentanil.
AmperozideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Alfentanil.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Alfentanil.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Alfentanil.
AprepitantThe serum concentration of Alfentanil can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Alfentanil is combined with Aripiprazole.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Alfentanil.
ArticaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Asenapine.
AtazanavirThe metabolism of Alfentanil can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Alfentanil.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Alfentanil.
AtomoxetineThe metabolism of Alfentanil can be decreased when combined with Atomoxetine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Alfentanil.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Alfentanil.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Alfentanil.
AzaperoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Azaperone.
AzelastineAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Alfentanil.
AzosemideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Alfentanil is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Barbital.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Alfentanil.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Bendroflumethiazide.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Alfentanil.
BenzocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Benzocaine.
BenzphetamineBenzphetamine may increase the analgesic activities of Alfentanil.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Alfentanil is combined with Benzyl alcohol.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Alfentanil.
BexaroteneThe serum concentration of Alfentanil can be decreased when it is combined with Bexarotene.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Alfentanil.
BoceprevirThe metabolism of Alfentanil can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Alfentanil.
BortezomibThe metabolism of Alfentanil can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Alfentanil can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Alfentanil.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Alfentanil.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Alfentanil is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
BrimonidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Bromazepam.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Alfentanil.
BrompheniramineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alfentanil.
BuprenorphineBuprenorphine may decrease the analgesic activities of Alfentanil.
BuprenorphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Alfentanil.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Alfentanil.
ButacaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Alfentanil is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Butethal.
ButorphanolButorphanol may decrease the analgesic activities of Alfentanil.
ButorphanolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Butorphanol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Alfentanil.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Alfentanil.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Alfentanil.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Alfentanil.
Canrenoic acidThe risk or severity of adverse effects can be increased when Alfentanil is combined with Canrenoic acid.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Alfentanil.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Alfentanil.
CarbinoxamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carfentanil.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Alfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carisoprodol.
CeritinibThe serum concentration of Alfentanil can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Alfentanil.
CetirizineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alfentanil.
ChlormezanoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chloroprocaine.
ChlorothiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Alfentanil.
ChlorphentermineChlorphentermine may increase the analgesic activities of Alfentanil.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Alfentanil.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Alfentanil.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorprothixene.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorzoxazone.
CimetidineThe serum concentration of Alfentanil can be increased when it is combined with Cimetidine.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Alfentanil.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Alfentanil.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Alfentanil.
CitalopramAlfentanil may increase the serotonergic activities of Citalopram.
ClarithromycinThe metabolism of Alfentanil can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Alfentanil.
ClemastineThe metabolism of Alfentanil can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Alfentanil is combined with Clidinium.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Alfentanil.
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Alfentanil.
clomethiazoleThe risk or severity of adverse effects can be increased when Alfentanil is combined with clomethiazole.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Alfentanil.
ClomipramineAlfentanil may increase the serotonergic activities of Clomipramine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Alfentanil.
ClonazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Clonazepam.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Alfentanil.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Alfentanil.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Alfentanil.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Alfentanil.
ClotrimazoleThe metabolism of Alfentanil can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Alfentanil.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Alfentanil.
CobicistatThe metabolism of Alfentanil can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Alfentanil.
CocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Alfentanil.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Alfentanil.
ConivaptanThe serum concentration of Alfentanil can be increased when it is combined with Conivaptan.
ConivaptanThe risk or severity of adverse effects can be increased when Alfentanil is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Alfentanil.
CrizotinibThe serum concentration of Alfentanil can be increased when it is combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cyclobenzaprine.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Alfentanil.
CyclosporineThe metabolism of Alfentanil can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Alfentanil.
CyclothiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Cyproheptadine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Alfentanil.
DabrafenibThe serum concentration of Alfentanil can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Alfentanil.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Alfentanil.
DantroleneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Alfentanil.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Alfentanil.
DapoxetineAlfentanil may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Alfentanil.
DarunavirThe metabolism of Alfentanil can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Alfentanil can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Alfentanil.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Alfentanil.
DeferasiroxThe serum concentration of Alfentanil can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Alfentanil can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Alfentanil is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Alfentanil.
DesmopressinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Detomidine.
DexamethasoneThe serum concentration of Alfentanil can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Alfentanil.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Alfentanil.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Alfentanil.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Alfentanil.
DextromoramideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Alfentanil.
DezocineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dezocine.
DiazepamDiazepam may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Alfentanil.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Alfentanil.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Alfentanil.
DifenoxinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Alfentanil.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Alfentanil.
DihydrocodeineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dihydrocodeine.
DihydroergotamineThe metabolism of Alfentanil can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dihydromorphine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Alfentanil.
DiltiazemThe serum concentration of Alfentanil can be increased when it is combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Diphenoxylate.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Alfentanil.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Alfentanil.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Alfentanil.
DoramectinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Alfentanil.
DoxycyclineThe metabolism of Alfentanil can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
DoxylamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Alfentanil is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
DronedaroneThe metabolism of Alfentanil can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Alfentanil.
DrospirenoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Alfentanil.
EcgonineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Alfentanil is combined with ECGONINE METHYL ESTER.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Alfentanil.
EfavirenzThe serum concentration of Alfentanil can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Alfentanil is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Efonidipine.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Alfentanil.
EluxadolineAlfentanil may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Alfentanil.
EntacaponeThe risk or severity of adverse effects can be increased when Alfentanil is combined with Entacapone.
EnzalutamideThe serum concentration of Alfentanil can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Alfentanil.
EplerenoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Eplerenone.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Alfentanil.
ErythromycinThe metabolism of Alfentanil can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Alfentanil.
EscitalopramAlfentanil may increase the serotonergic activities of Escitalopram.
Eslicarbazepine acetateThe serum concentration of Alfentanil can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Estazolam.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Alfentanil.
EstriolThe serum concentration of Estriol can be increased when it is combined with Alfentanil.
EstroneThe serum concentration of Estrone can be increased when it is combined with Alfentanil.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Alfentanil.
Etacrynic acidThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etacrynic acid.
EthanolAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Alfentanil.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Alfentanil.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Alfentanil.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Alfentanil.
EthosuximideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Alfentanil.
EtoperidoneAlfentanil may increase the serotonergic activities of Etoperidone.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Alfentanil.
EtorphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etorphine.
EtravirineThe serum concentration of Alfentanil can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Alfentanil.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Alfentanil.
EzogabineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fencamfamine.
FenfluramineAlfentanil may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fentanyl.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Alfentanil.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Alfentanil.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Alfentanil.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Alfentanil.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Alfentanil.
FlibanserinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Flibanserin.
FluconazoleThe metabolism of Alfentanil can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Flunitrazepam.
FluoxetineAlfentanil may increase the serotonergic activities of Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Flupentixol.
FluphenazineFluphenazine may increase the hypotensive activities of Alfentanil.
FluphenazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Alfentanil.
FluspirileneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fluspirilene.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Alfentanil.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fluticasone Propionate.
FluvoxamineAlfentanil may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe metabolism of Alfentanil can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Alfentanil can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Alfentanil can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Furosemide.
Fusidic AcidThe serum concentration of Alfentanil can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Alfentanil is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Alfentanil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Alfentanil is combined with Gamma Hydroxybutyric Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Alfentanil.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Alfentanil.
GlutethimideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Glutethimide.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Alfentanil.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Alfentanil.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Alfentanil.
GuanfacineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Alfentanil.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Alfentanil.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Alfentanil.
HalothaneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Heroin.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Alfentanil.
HexobarbitalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hexobarbital.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Alfentanil.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hydrocodone.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Alfentanil.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Alfentanil.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Alfentanil.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
HydroxyzineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Alfentanil.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Alfentanil.
IdelalisibThe serum concentration of Alfentanil can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Iloperidone.
ImatinibThe metabolism of Alfentanil can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Alfentanil.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Alfentanil.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Alfentanil.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Alfentanil.
IndalpineAlfentanil may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Indapamide.
IndinavirThe metabolism of Alfentanil can be decreased when combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Alfentanil.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Alfentanil.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Alfentanil.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Alfentanil.
IsavuconazoniumThe metabolism of Alfentanil can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Alfentanil.
IsosorbideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Isosorbide.
IsradipineThe metabolism of Alfentanil can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Alfentanil can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Alfentanil can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Alfentanil.
KetamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Alfentanil.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Alfentanil.
KetobemidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ketobemidone.
KetoconazoleThe metabolism of Alfentanil can be decreased when combined with Ketoconazole.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Alfentanil.
KW-3902The risk or severity of adverse effects can be increased when Alfentanil is combined with KW-3902.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Alfentanil.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Alfentanil.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Alfentanil.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Alfentanil.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Alfentanil.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Alfentanil.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Alfentanil.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Alfentanil.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Alfentanil.
LevobupivacaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Alfentanil.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levomethadyl Acetate.
LevomilnacipranAlfentanil may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alfentanil.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Alfentanil.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Alfentanil.
LithiumThe risk or severity of adverse effects can be increased when Alfentanil is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Lofentanil.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Alfentanil.
LopinavirThe metabolism of Alfentanil can be decreased when combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alfentanil.
LosartanThe serum concentration of Losartan can be increased when it is combined with Alfentanil.
LovastatinThe metabolism of Alfentanil can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Alfentanil.
Lu AA21004Alfentanil may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Alfentanil.
LuliconazoleThe serum concentration of Alfentanil can be increased when it is combined with Luliconazole.
LurasidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Maprotiline.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Alfentanil.
MeclizineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Alfentanil is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Alfentanil.
MepivacaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Alfentanil.
MersalylThe risk or severity of adverse effects can be increased when Alfentanil is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Alfentanil.
MesoridazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Alfentanil.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methadyl Acetate.
MethamphetamineMethamphetamine may increase the analgesic activities of Alfentanil.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Alfentanil.
MethapyrileneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Alfentanil.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Alfentanil.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Alfentanil.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Alfentanil.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methylphenobarbital.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Alfentanil.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Alfentanil.
MetolazoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Metolazone.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Alfentanil.
MetyrosineAlfentanil may increase the sedative activities of Metyrosine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Alfentanil.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Alfentanil.
MifepristoneThe metabolism of Alfentanil can be decreased when combined with Mifepristone.
MilnacipranAlfentanil may increase the serotonergic activities of Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Alfentanil.
MirtazapineAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Alfentanil.
MitotaneThe serum concentration of Alfentanil can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Alfentanil.
ModafinilThe serum concentration of Alfentanil can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Alfentanil.
MorphineThe serum concentration of Morphine can be increased when it is combined with Alfentanil.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Alfentanil.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Alfentanil.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Alfentanil.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
NabiloneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nabilone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Alfentanil.
NafcillinThe serum concentration of Alfentanil can be decreased when it is combined with Nafcillin.
NalbuphineNalbuphine may decrease the analgesic activities of Alfentanil.
NalbuphineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nalbuphine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Alfentanil.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Alfentanil.
NaltrexoneThe therapeutic efficacy of Alfentanil can be decreased when used in combination with Naltrexone.
NefazodoneThe metabolism of Alfentanil can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Alfentanil can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Alfentanil.
NetupitantThe serum concentration of Alfentanil can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Alfentanil can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Alfentanil.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Alfentanil.
NilotinibThe metabolism of Alfentanil can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Alfentanil.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Alfentanil.
NitrazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nitrous oxide.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Alfentanil.
NormethadoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Alfentanil.
OlanzapineAlfentanil may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Alfentanil.
OlaparibThe metabolism of Alfentanil can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Olopatadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Alfentanil.
OndansetronThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Alfentanil is combined with Opium.
OrphenadrineAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Alfentanil.
OsanetantThe risk or severity of adverse effects can be increased when Alfentanil is combined with Osanetant.
OsimertinibThe serum concentration of Alfentanil can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Alfentanil is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Oxybuprocaine.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Alfentanil.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alfentanil.
OxymorphoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Oxymorphone.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Alfentanil.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Alfentanil.
PalbociclibThe serum concentration of Alfentanil can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Paliperidone.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Alfentanil.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Alfentanil.
ParaldehydeAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Alfentanil.
ParoxetineAlfentanil may increase the serotonergic activities of Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Alfentanil.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Alfentanil.
PentazocinePentazocine may decrease the analgesic activities of Alfentanil.
PentazocineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Alfentanil.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Alfentanil.
PerampanelThe risk or severity of adverse effects can be increased when Alfentanil is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Alfentanil is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Alfentanil.
PerphenazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Alfentanil.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Alfentanil.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Alfentanil.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Phenoxyethanol.
PhenterminePhentermine may increase the analgesic activities of Alfentanil.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Alfentanil.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Alfentanil.
PimozideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Alfentanil.
PipotiazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Alfentanil.
PiretanideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Piretanide.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Alfentanil.
PizotifenThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Alfentanil.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Alfentanil.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Alfentanil.
PosaconazoleThe metabolism of Alfentanil can be decreased when combined with Posaconazole.
PotassiumThe risk or severity of adverse effects can be increased when Alfentanil is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Potassium Citrate.
PramipexoleAlfentanil may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Pramocaine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Alfentanil.
PrazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Prazepam.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Alfentanil.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Alfentanil.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Alfentanil.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfentanil.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Alfentanil.
PrimidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Alfentanil.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Alfentanil.
ProchlorperazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Alfentanil.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Alfentanil.
PromazinePromazine may increase the hypotensive activities of Alfentanil.
PromazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Alfentanil.
PromethazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Alfentanil.
ProparacaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Propoxycaine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Alfentanil.
ProtriptylineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Alfentanil.
PSD502The risk or severity of adverse effects can be increased when Alfentanil is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Quazepam.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Alfentanil.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Alfentanil.
QuinethazoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Alfentanil.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Alfentanil.
QuinineThe serum concentration of Quinine can be increased when it is combined with Alfentanil.
RamelteonThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ramelteon.
RamosetronAlfentanil may increase the constipating activities of Ramosetron.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Alfentanil.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Alfentanil.
RanolazineThe metabolism of Alfentanil can be decreased when combined with Ranolazine.
RemifentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Alfentanil.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Alfentanil.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Alfentanil.
RifabutinThe metabolism of Alfentanil can be increased when combined with Rifabutin.
RifampicinThe metabolism of Alfentanil can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Alfentanil.
RifapentineThe metabolism of Alfentanil can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Alfentanil.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Alfentanil.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Alfentanil.
RitonavirThe metabolism of Alfentanil can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Alfentanil.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Alfentanil.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Alfentanil.
RomifidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Romifidine.
RopiniroleAlfentanil may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Alfentanil.
RotigotineAlfentanil may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Alfentanil.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Alfentanil is combined with S-Ethylisothiourea.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Alfentanil.
SaquinavirThe metabolism of Alfentanil can be decreased when combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Alfentanil.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Alfentanil.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Alfentanil.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Alfentanil.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Alfentanil.
SertindoleThe risk or severity of adverse effects can be increased when Alfentanil is combined with Sertindole.
SertralineAlfentanil may increase the serotonergic activities of Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Sevoflurane.
SildenafilThe metabolism of Alfentanil can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Alfentanil.
SiltuximabThe serum concentration of Alfentanil can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Alfentanil can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Alfentanil.
Sodium oxybateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Sodium oxybate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Alfentanil.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Alfentanil.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Alfentanil.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Alfentanil.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Alfentanil.
SpironolactoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Spironolactone.
St. John's WortThe serum concentration of Alfentanil can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Alfentanil.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Alfentanil.
SulfisoxazoleThe metabolism of Alfentanil can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Alfentanil.
SuvorexantThe risk or severity of adverse effects can be increased when Alfentanil is combined with Suvorexant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Alfentanil.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Alfentanil.
TapentadolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Alfentanil.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Alfentanil.
TelaprevirThe metabolism of Alfentanil can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Alfentanil.
TelithromycinThe metabolism of Alfentanil can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Alfentanil.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Alfentanil.
TetrabenazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tetrodotoxin.
ThalidomideAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Alfentanil.
TheobromineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Alfentanil is combined with Thiamylal.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Alfentanil.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Alfentanil.
ThioridazineThioridazine may increase the hypotensive activities of Alfentanil.
ThioridazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tiagabine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Alfentanil.
TiclopidineThe metabolism of Alfentanil can be decreased when combined with Ticlopidine.
TicrynafenThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tiletamine.
TimololThe serum concentration of Timolol can be increased when it is combined with Alfentanil.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Alfentanil.
TizanidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tizanidine.
TocilizumabThe serum concentration of Alfentanil can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tolcapone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Alfentanil.
TolvaptanThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Alfentanil is combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Alfentanil.
TorasemideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Torasemide.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Alfentanil.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Alfentanil.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Alfentanil.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Alfentanil.
TrazodoneAlfentanil may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Alfentanil.
TriamtereneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Triazolam.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Alfentanil.
TrifluoperazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Alfentanil.
TriflupromazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Alfentanil.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Alfentanil.
TrimipramineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Alfentanil.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Alfentanil.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Alfentanil.
UlaritideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ularitide.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Alfentanil.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Alfentanil.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Alfentanil.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Alfentanil.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Alfentanil.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Alfentanil.
VenlafaxineThe metabolism of Alfentanil can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Alfentanil.
VerapamilThe metabolism of Alfentanil can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Alfentanil.
VigabatrinThe risk or severity of adverse effects can be increased when Alfentanil is combined with Vigabatrin.
VilazodoneAlfentanil may increase the serotonergic activities of Vilazodone.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Alfentanil.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Alfentanil.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Alfentanil.
VoriconazoleThe metabolism of Alfentanil can be decreased when combined with Voriconazole.
VortioxetineAlfentanil may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Alfentanil.
XylazineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Alfentanil.
ZimelidineAlfentanil may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe metabolism of Alfentanil can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Alfentanil.
ZonisamideThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Alfentanil is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Garrido M, Gubbens-Stibbe J, Tukker E, Cox E, von Frijtag J, Kunzel D, IJzerman A, Danhof M, van der Graaf PH: Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo. Pharm Res. 2000 Jun;17(6):653-9. [PubMed:10955836 ]
  2. Lotsch J, Geisslinger G: Are mu-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol Med. 2005 Feb;11(2):82-9. [PubMed:15694871 ]
  3. Oertel BG, Schmidt R, Schneider A, Geisslinger G, Lotsch J: The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers. Pharmacogenet Genomics. 2006 Sep;16(9):625-36. [PubMed:16906017 ]
  4. Leung A, Wallace MS, Ridgeway B, Yaksh T: Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 2001 Mar;91(1-2):177-87. [PubMed:11240090 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Klees TM, Sheffels P, Dale O, Kharasch ED: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11. Epub 2004 Nov 22. [PubMed:15557344 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Kharasch ED, Walker A, Isoherranen N, Hoffer C, Sheffels P, Thummel K, Whittington D, Ensign D: Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clin Pharmacol Ther. 2007 Oct;82(4):410-26. Epub 2007 Jun 6. [PubMed:17554244 ]
  2. Klees TM, Sheffels P, Dale O, Kharasch ED: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11. Epub 2004 Nov 22. [PubMed:15557344 ]
  3. Klees TM, Sheffels P, Thummel KE, Kharasch ED: Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. Anesthesiology. 2005 Mar;102(3):550-6. [PubMed:15731592 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Belpaire FM, Bogaert MG: Binding of alfentanil to human alpha 1-acid glycoprotein, albumin and serum. Int J Clin Pharmacol Ther Toxicol. 1991 Mar;29(3):96-102. [PubMed:2071261 ]
  2. Kumar K, Crankshaw DP, Morgan DJ, Beemer GH: The effect of cardiopulmonary bypass on plasma protein binding of alfentanil. Eur J Clin Pharmacol. 1988;35(1):47-52. [PubMed:3146505 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Belpaire FM, Bogaert MG: Binding of alfentanil to human alpha 1-acid glycoprotein, albumin and serum. Int J Clin Pharmacol Ther Toxicol. 1991 Mar;29(3):96-102. [PubMed:2071261 ]
  2. Kumar K, Crankshaw DP, Morgan DJ, Beemer GH: The effect of cardiopulmonary bypass on plasma protein binding of alfentanil. Eur J Clin Pharmacol. 1988;35(1):47-52. [PubMed:3146505 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. [PubMed:11964599 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23