Showing drug card for Sodium lauryl sulfate (DB00815)

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Version	2.5
Creation Date	2005-06-13 13:24:05
Update Date	2009-04-16 16:48:01
Primary Accession Number	DB00815
Secondary Accession Number	APRD01606
Name	Sodium lauryl sulfate
Drug Type	Approved Small Molecule
Description	An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.
Synonyms	Dodecyl alcohol, hydrogen sulfate, sodium salt Dodecyl sodium sulfate Dodecyl sulfate sodium Dodecyl sulfate sodium salt Dodecyl sulfate, sodium salt Lauryl sodium sulfate Lauryl sulfate sodium Lauryl sulfate sodium salt Lauryl sulfate, sodium salt Laurylsiran sodny [czech] Lauyl sodium sulfate Monododecyl sodium sulfate N-dodecyl sulfate sodium NADDS NALS Natrium laurylsulfuricum Natriumlaurylsulfat Sodium dodecyl sulfate Sodium lauryl sulphate Sodium monododecyl sulfate Sodium monolauryl sulfate Sodium n-dodecyl sulfate Sodiumlauryl ether sulfate Sulfuric acid dodecyl ester sodium salt Sulfuric acid monododecyl ester sodium salt Sulfuric acid, monododecyl ester, sodium salt
Brand Names	Adeka Hope LS 35 Adeka Hope LS 90 Akyposal NLS Akyposal SDS Alscoap LN 40A Alscoap LN 90 Alscoap MP 90N Alscoap SP 40 Alscoap-LN 90P Anticerumen Aquarex me Aquarex methyl Avirol 101 Avirol 118 conc Avirol SL 2010 Berol 452 Bio-Soft SDBS 60 Calfoam ES 303 Calfoam SLS 30 Carsonol SLS Carsonol SLS paste b Carsonol SLS special Carsonol SLS-s Caswell No. 779 Conco sulfate WA-1200 Conco sulfate WA-1245 Conco sulfate WAG Conco sulfate WAN Conco sulfate WAS Conco sulfate WN Conco sulfate wa Cycloryl 21 Cycloryl 21LS Cycloryl 31 Cycloryl 580 Cycloryl 585N Dehydag sulfate GL Dehydag sulfate GL emulsion Dehydag sulphate GL emulsion Dehydrag sulfate GL emulsion Dermacide Detergent 66 Dreft Dupanol waq Duponal Duponal waqe Duponol Duponol ME Duponol QC Duponol QX Duponol WA Duponol WA DRY Duponol WAQ Duponol c Duponol methyl Duponol waqa Duponol waqe Duponol waqm Emal 10 Emal 10 Needle Emal 10 Powder Emal 2F Emal 2F Needle Emal 2F30 Emal o Emal os Emersal 6400 Empicol 0303 Empicol 0303VA Empicol BSD 70 Empicol LPZ Empicol LS 30 Empicol LX 2 Empicol LX 28 Empicol LX 28R Empicol LX 42 Empicol LXSV 938U Empicol LXV Empicol LY 28S Empicol LZ/D Empimin SDS Emulsogen LS Equex S Equex SP Finasol OSR 2 Finasol OSR2 Finasol osr(sub 2) Fongrapol LSS Gardinol Gardinol type detergent Genapol LSS Hexamol SLS Incronol SLS Irium Jordanol SL-300 K 12 (surfactant) Lanette wax s Lanette wax-s Maprobix neu Maprofix 563 Maprofix LK Maprofix neu Maprofix wac Maprofix wac-la Melanol CL Melanol CL 30 Monagen Y 100 Monogen LH Monogen Y 100 Monogen Y 500 Montopol LA paste Needle 10 Neutrazyme Nikkol SLS Nissan Sintrex L 100 Nissan persoft SP Odoripon Al 95 Orvus WA Orvus WA paste Perklankrol ESD 60 Perlandrol L Perlankrol E.S.D. 60 Perlankrol L Pionin A 21 Polystep B 3 Polystep B 5 Quolac ex-ub Rewopol NLS 28 Rewopol NLS 30 Rhodapon LCP Rhodapon LSB Rhodapon SB Rhodapon SB 8208S Rhodapon SM Rhodapon UB Richonol A Richonol AF Richonol C Rolpon LS Rosulfan L 1 Sandet ona Silipon RN 6031 Sinnopon LS 100 Sinnopon LS 95 Sinolin 90TK-N Sintapon l Sintrex L 100 Sipex SB Sipex SD Sipex SP Sipex op Sipex ub Sipon LCS 98 Sipon LS Sipon LS 100 Sipon LSB Sipon PD Sipon WD Sipon ub Solsol needles Sorpol 5029O Sorpol 8070 Standapol 112 conc Standapol WA-AC Standapol WAQ Standapol WAQ special Standapol WAQ-LC Standapol WAS 100 Stanfax 234 Steinapol NLS Steinapol NLS 90 Stepanal WAC Stepanol ME Stepanol ME DRY Stepanol ME DRY AW Stepanol ME DRY SLS Stepanol T 28 Stepanol WA Stepanol WA 100 Stepanol WA extra Stepanol WA paste Stepanol WA special Stepanol WA-100 Stepanol WAC Stepanol WAQ Stepanol methyl Stepanol methyl DRY AW Sterling WA paste Sterling waq-CH Sterling waq-cosmetic Sulfetal L 95 Sulfochem SLS Sulfolyser Sulfopon T 30 Sulfopon WA 1 Sulfopon WA 1 Special Sulfopon WA 2 Sulfopon WA 3 Sulfopon WA1 Special Sulfopon WA2 Sulfopon WA3 Sulfotex WA Sulfotex wala Sunnol LM 1130 Supralate C Surfactant K12 Surfax 220 Swascol 1P Swascol 3L Swascol 4L Syntapon L Tarapon K 12 Texapon DL conc. Texapon K 12 Texapon K 1296 Texapon K 1298 Texapon K 12G Texapon K12 Texapon K1296 Texapon L 100 Texapon V HC Texapon V HC powder Texapon Z high conc. needles Texapon ZHC Trepenol WA Ufarol AM 30 Ufarol TCL 92 Ultra sulfate SL-1 WAQE Witcolate A
Brand Mixtures	For sope (sodium lauryl sulfate + stearic acid) Plax anti-plaque den rinse peppermint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate) Plax anti-plaque dent rinse soft mint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate) Plax anti-plaque dental rinse (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
Chemical IUPAC Name	sodium dodecyl sulfate
Chemical Formula	C₁₂H₂₅NaO₄S
Chemical Structure
CAS Registry Number	151-21-3
InChI Identifier	InChI=1/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1/fC12H25O4S.Na/q-1;m
InChI Key	DBMJMQXJHONAFJ-AITAGSLOCU
KEGG Drug	D01045
KEGG Compound	C11166
PubChem Compound	9028
PubChem Substance	13348
ChEBI ID	8984
PharmGKB ID	PA451398
HET ID	Not Available
GenBank ID	Not Available
Drug ID Number [DIN]	Not Available
RxList Link	Not Available
PDRhealth Link	Not Available
Wikipedia Link	http://en.wikipedia.org/wiki/Sodium_lauryl_sulfate
FDA Label	Not Available
Material Safety Data Sheet (MSDS)	Show PDF
Synthesis Reference	Not Available
Average Molecular Weight	288.3790
Monoisotopic Molecular Weight	288.1371
State	Solid
Melting Point	205.5 oC
Experimental Water Solubility	100 mg/mL [SINGER,MM & TJEERDEMA,RS (1993)] Source: PhysProp
Predicted Water Solubility	1.21e-02 mg/mL Calculated using ALOGPS
Experimental LogP/Hydrophobicity	1.60 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP	3.86 Calculated using ALOGPS
Experimental LogS	Not Available
Predicted LogS	-4.38 Calculated using ALOGPS
Experimental Caco2 Permeability	Not Available
pKa/Isoelectric Point	Not Available
Mass Spectrum	Not Available
MOL File	Show \| Download
SDF File	Show \| Download
PDB File	Show \| Download
2D Structure
3D Structure
Experimental PDB ID	Not Available
Isomeric SMILES	[Na+].CCCCCCCCCCCCOS([O-])(=O)=O
Canonical SMILES	[Na+].CCCCCCCCCCCCOS([O-])(=O)=O
Drug Category	Surface-Active Agents
ATC Codes	Not Available
AHFS Codes	Not Available
Indication	Used as a surfactant in shampoos and toothpastes.
Pharmacology	Not Available
Mechanism of Action	Sodium Lauryl Sulfate (SLS) is a foaming agent naturally derived from coconut and/or palm kernel oil. SLS has a long history of safe use in a variety of consumer personal care products. It is used in creams and pastes to properly disperse the ingredients.
Absorption	Not Available
Toxicity	ORAL (LD50): Acute: 1288 mg/kg [Rat]
Protein Binding	Not Available
Biotransformation	Not Available
Half Life	Not Available
Dosage Forms	Not Available
Patient Information	Not Available
Contraindications	Not Available
Interactions	Not Available
Drug Interactions	Not Available
Food Interactions	Not Available
Pathways	Not Available
General References	Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. [PubMed ] Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. [PubMed ] Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. [PubMed ] Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. [PubMed ] Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. [PubMed ] Wikipedia
Organisms Affected	Humans and other mammals
Targets	Serum albumin

Drug Target 1 [top]

Target 1 ID

587

Target 1 Name

Serum albumin

Target 1 Synonyms

Serum albumin precursor

Target 1 Gene Name

ALB

Target 1 Protein Sequence

>Serum albumin precursor

MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

Target 1 Number of Residues

619

Target 1 Molecular Weight

69367

Target 1 Theoretical pI

6.21

Target 1 GO Classification

Function
transporter activity carrier activity
Process
physiological process cellular physiological process transport
Component
extracellular region extracellular space

Target 1 General Function

Involved in antioxidant activity

Target 1 Specific Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Pfam Domain Function

Serum_albumin (PF00273 )

Target 1 Signals

1-18

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non-Essential

Target 1 GenBank ID Protein

28590

Target 1 UniProtKB/Swiss-Prot ID

P02768

Target 1 UniProtKB/Swiss-Prot Entry Name

ALBU_HUMAN Link Image

Target 1 PDB ID

1HA2

Target 1 PDB File

Show

Target 1 3D Structure

Target 1 Cellular Location

Secreted protein

Target 1 Gene Sequence

>1830 bp

ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

Target 1 GenBank Gene ID

Target 1 GeneCard ID

ALB

Target 1 GenAtlas ID

ALB

Target 1 HGNC ID

HGNC:399

Target 1 Chromosome Location

Target 1 Locus

4q11-q13

Target 1 SNPs

SNPJam Report Link Image

Target 1 General References

Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K: Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng. 1999 Jun;12(6):439-46. [PubMed ]
Bhattacharya AA, Curry S, Franks NP: Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem. 2000 Dec 8;275(49):38731-8. [PubMed ]
Minchiotti L, Campagnoli M, Rossi A, Cosulich ME, Monti M, Pucci P, Kragh-Hansen U, Granel B, Disdier P, Weiller PJ, Galliano M: A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. Eur J Biochem. 2001 Jan;268(2):344-52. [PubMed ]
Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. Genome Res. 2001 Aug;11(8):1392-403. [PubMed ]
Spahr CS, Davis MT, McGinley MD, Robinson JH, Bures EJ, Beierle J, Mort J, Courchesne PL, Chen K, Wahl RC, Yu W, Luethy R, Patterson SD: Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I. Profiling an unfractionated tryptic digest. Proteomics. 2001 Jan;1(1):93-107. [PubMed ]
Petitpas I, Grune T, Bhattacharya AA, Curry S: Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. J Mol Biol. 2001 Dec 14;314(5):955-60. [PubMed ]
Meloun B, Moravek L, Kostka V: Complete amino acid sequence of human serum albumin. FEBS Lett. 1975 Oct 15;58(1):134-7. [PubMed ]
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed ]
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed ]
Minchiotti L, Galliano M, Stoppini M, Ferri G, Crespeau H, Rochu D, Porta F: Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. Biochim Biophys Acta. 1992 Mar 12;1119(3):232-8. [PubMed ]
1518850 Carlson J, Sakamoto Y, Laurell CB, Madison J, Watkins S, Putnam FW: Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8225-9.
1630489 He XM, Carter DC: Atomic structure and chemistry of human serum albumin. Nature. 1992 Jul 16;358(6383):209-15.
1859851 Peach RJ, Brennan SO: Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp----Asn). Biochim Biophys Acta. 1991 Jul 26;1097(1):49-54.
1946412 Madison J, Arai K, Sakamoto Y, Feld RD, Kyle RA, Watkins S, Davis E, Matsuda Y, Amaki I, Putnam FW: Genetic variants of serum albumin in Americans and Japanese. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9853-7.
2068071 Watkins S, Madison J, Davis E, Sakamoto Y, Galliano M, Minchiotti L, Putnam FW: A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5959-63.
2104980 Brennan SO, Myles T, Peach RJ, Donaldson D, George PM: Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site. Proc Natl Acad Sci U S A. 1990 Jan;87(1):26-30.
2247440 Galliano M, Minchiotti L, Porta F, Rossi A, Ferri G, Madison J, Watkins S, Putnam FW: Mutations in genetic variants of human serum albumin found in Italy. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8721-5.
2374930 Carter DC, He XM: Structure of human serum albumin. Science. 1990 Jul 20;249(4966):302-3.
2404284 Arai K, Madison J, Shimizu A, Putnam FW: Point substitutions in albumin genetic variants from Asia. Proc Natl Acad Sci U S A. 1990 Jan;87(1):497-501.
2419329 Urano Y, Watanabe K, Sakai M, Tamaoki T: The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts. J Biol Chem. 1986 Mar 5;261(7):3244-51.
2437111 Carraway RE, Mitra SP, Cochrane DE: Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). J Biol Chem. 1987 May 5;262(13):5968-73.
2727704 Carter DC, He XM, Munson SH, Twigg PD, Gernert KM, Broom MB, Miller TY: Three-dimensional structure of human serum albumin. Science. 1989 Jun 9;244(4909):1195-8.
2762316 Arai K, Madison J, Huss K, Ishioka N, Satoh C, Fujita M, Neel JV, Sakurabayashi I, Putnam FW: Point substitutions in Japanese alloalbumins. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6092-6.
2911589 Arai K, Ishioka N, Huss K, Madison J, Putnam FW: Identical structural changes in inherited albumin variants from different populations. Proc Natl Acad Sci U S A. 1989 Jan;86(2):434-8.
3009475 Minghetti PP, Ruffner DE, Kuang WJ, Dennison OE, Hawkins JW, Beattie WG, Dugaiczyk A: Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4. J Biol Chem. 1986 May 25;261(15):6747-57.
3087352 Mogard MH, Kobayashi R, Chen CF, Lee TD, Reeve JR Jr, Shively JE, Walsh JH: The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8.
3474609 Takahashi N, Takahashi Y, Blumberg BS, Putnam FW: Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4413-7.
3479777 Takahashi N, Takahashi Y, Isobe T, Putnam FW, Fujita M, Satoh C, Neel JV: Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8001-5.
3828358 Brennan SO, Herbert P: Albumin Canterbury (313 Lys----Asn). A point mutation in the second domain of serum albumin. Biochim Biophys Acta. 1987 Apr 8;912(2):191-7.
6171778 Lawn RM, Adelman J, Bock SC, Franke AE, Houck CM, Najarian RC, Seeburg PH, Wion KL: The sequence of human serum albumin cDNA and its expression in E. coli. Nucleic Acids Res. 1981 Nov 25;9(22):6103-114.
6275391 Dugaiczyk A, Law SW, Dennison OE: Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sci U S A. 1982 Jan;79(1):71-5.
656055 Jacobsen C: Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin. Biochem J. 1978 May 1;171(2):453-9.
7852505 Rushbrook JI, Becker E, Schussler GC, Divino CM: Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. J Clin Endocrinol Metab. 1995 Feb;80(2):461-7.
7895732 Corbett JM, Wheeler CH, Baker CS, Yacoub MH, Dunn MJ: The human myocardial two-dimensional gel protein database: update 1994. Electrophoresis. 1994 Nov;15(11):1459-65.
7902134 Galliano M, Minchiotti L, Iadarola P, Stoppini M, Giagnoni P, Watkins S, Madison J, Putnam FW: Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). Biochim Biophys Acta. 1993 Nov 25;1225(1):27-32.
8022807 Madison J, Galliano M, Watkins S, Minchiotti L, Porta F, Rossi A, Putnam FW: Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6476-80.
8048949 Sunthornthepvarakul T, Angkeow P, Weiss RE, Hayashi Y, Refetoff S: An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. Biochem Biophys Res Commun. 1994 Jul 29;202(2):781-7.
8347685 Brennan SO, Fellowes AP: Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177. Biochim Biophys Acta. 1993 Aug 4;1182(1):46-50.
8513793 Minchiotti L, Galliano M, Zapponi MC, Tenni R: The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant. Eur J Biochem. 1993 Jun 1;214(2):437-44.
9329347 Wada N, Chiba H, Shimizu C, Kijima H, Kubo M, Koike T: A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. J Clin Endocrinol Metab. 1997 Oct;82(10):3246-50.
955075 Walker JE: Lysine residue 199 of human serum albumin is modified by acetylsalicyclic acid. FEBS Lett. 1976 Jul 15;66(2):173-5.
9589637 Sunthornthepvarakul T, Likitmaskul S, Ngowngarmratana S, Angsusingha K, Kitvitayasak S, Scherberg NH, Refetoff S: Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect. J Clin Endocrinol Metab. 1998 May;83(5):1448-54.
9731778 Curry S, Mandelkow H, Brick P, Franks N: Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 1998 Sep;5(9):827-35.

Target 1 Drug References

Chang-Ying Y, An-Xin H, Yi L, Hui T, Song-Sheng Q: Some properties of the interaction between 2,2'-diselenadibenzoic acid and serum albumins. J Pharm Biomed Anal. 2005 Sep 1;39(1-2):263-7. [PubMed ]
Choi EJ, Foster MD: Surfactant displacement of human serum albumin adsorbed on loosely packed self-assembled monolayers: cetyltrimethylammonium bromide versus sodium dodecyl sulfate. J Colloid Interface Sci. 2003 May 15;261(2):273-82. [PubMed ]
Santos SF, Zanette D, Fischer H, Itri R: A systematic study of bovine serum albumin (BSA) and sodium dodecyl sulfate (SDS) interactions by surface tension and small angle X-ray scattering. J Colloid Interface Sci. 2003 Jun 15;262(2):400-8. [PubMed ]
Cao WG, Jiao QC, Liu Q: [Spatial orientation interaction mechanism of three component complex of protein--BSA/SDS/Azur a system] Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Sep;25(9):1478-81. [PubMed ]
Schweitzer B, Felippe AC, Dal Bo A, Minatti E, Zanette D, Lopes A: Sodium dodecyl sulfate promoting a cooperative association process of sodium cholate with bovine serum albumin. J Colloid Interface Sci. 2006 Jun 1;298(1):457-66. Epub 2006 Feb 2. [PubMed ]

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government. This project is also supported in part by GenomeQuest, Inc., an enterprise genomic information company serving the life science community.