| Identification |
|---|
| Name |
Hydroxypropyl cellulose |
| Accession Number |
DB00840
(APRD01023)
|
| Type |
small molecule |
| Groups |
approved |
| Description |
Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CHCH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. |
| Structure |
|
| Synonyms |
| Hydroxypropylmethylcellulose phthalate |
| Hypromellose phthtalate |
|
| Salts |
Not Available |
| Brand names |
|
| Brand mixtures |
Not Available |
| Categories |
- Ophthalmic Protectant
- Artificial Tears
|
| CAS number |
9004-64-2 |
| Weight |
Not Available
|
| Chemical Formula |
Not Available |
| InChI Key |
Not Available |
| InChI |
Not Available
|
| IUPAC Name |
Not Available
|
| SMILES |
Not Available
|
| Mass Spec |
Not Available
|
| Taxonomy |
|---|
| Kingdom |
Not Available |
| Classes |
Not Available |
| Substructures |
Not Available |
| Pharmacology |
|---|
| Indication |
Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. |
| Pharmacodynamics |
Hydroxypropyl cellulose (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also acts to lubricate and protect the eye. Hydroxypropyl cellulose usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed. |
| Mechanism of action |
Hydroxypropyl cellulose is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is a water-soluble thickener, emulsifier and film-former often used in tablet coating. |
| Absorption |
Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces. |
| Volume of distribution |
Not Available |
| Protein binding |
None |
| Metabolism |
Hydroxypropyl cellulose is a physiologically inert substance. In a study of rats fed hydroxypropyl cellulose or unmodified cellulose at levels up to 5% of their diet, it was found that the two were biologically equivalent in that neither was metabolized.
|
| Route of elimination |
Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces. |
| Half life |
Not Available |
| Clearance |
Not Available |
| Toxicity |
LD50=10200 mg/kg (oral, rat) |
| Affected organisms |
|
| Pathways |
Not Available |
| Pharmacoeconomics |
|---|
| Manufacturers |
|
| Packagers |
|
| Dosage forms |
| Form |
Route |
Strength |
| Insert |
Ophthalmic |
|
|
| Prices |
| Unit description |
Cost |
Unit |
| Lacrisert 60 5 mg Insert Box |
281.99 USD |
box |
| Lacrisert 5 mg eye insert |
3.68 USD |
insert |
| Hydroxypropylcellulose powd |
0.51 USD |
g |
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational
purposes only.
|
| Patents |
Not Available |
| Properties |
|---|
| State |
solid |
| Experimental Properties |
Not Available |
| Predicted Properties |
Not Available |
| References |
|---|
| Synthesis Reference |
Not Available
|
| General Reference |
- Wander AH: Long-term use of hydroxypropyl cellulose ophthalmic insert to relieve symptoms of dry eye in a contact lens wearer: case-based experience. Eye Contact Lens. 2011 Jan;37(1):39-44. Pubmed
- McDonald M, D’Aversa G, Perry HD, Wittpenn JR, Nelinson DS: Correlating patient-reported response to hydroxypropyl cellulose ophthalmic insert (LACRISERT) therapy with clinical outcomes: tools for predicting response. Curr Eye Res. 2010 Oct;35(10):880-7. Pubmed
- Luchs JI, Nelinson DS, Macy JI: Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. Cornea. 2010 Dec;29(12):1417-27. Pubmed
|
| External Links |
|
| ATC Codes |
Not Available |
| AHFS Codes |
Not Available |
| PDB Entries |
Not Available |
| FDA label |
show (187 KB)
|
| MSDS |
show (73.5 KB)
|
| Interactions |
|---|
| Drug Interactions |
Searched, but no interactions found. |
| Food Interactions |
Not Available |
