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Identification
NameDigitoxin
Accession NumberDB01396
TypeSmall Molecule
GroupsApproved
DescriptionA cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Structure
Thumb
Synonyms
Crystodigin (tn)
Digitoksin
Digitoxin
Digitoxinum
Digitoxoside
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Digitaline Welcker Tab 0.1mgtablet.1 mgoralWelcker Lyster Ltd., Division Of Technilab Inc.1951-12-312001-09-05Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CrystodiginNot Available
TardigalNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIE90NZP2L9U
CAS number71-63-6
WeightAverage: 764.9391
Monoisotopic: 764.434692134
Chemical FormulaC41H64O13
InChI KeyInChIKey=WDJUZGPOPHTGOT-XUDUSOBPSA-N
InChI
InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
IUPAC Name
4-[(1S,2S,5S,7R,10R,11S,14R,15R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2,5-dihydrofuran-2-one
SMILES
[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[[email protected]](CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[[email protected]]1C[[email protected]](O)[[email protected]](O[[email protected]]2C[[email protected]](O)[[email protected]](O[[email protected]]3C[[email protected]](O)[[email protected]](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as cardenolide glycosides and derivatives. These are compounds containing a carbohydrate glycosidically bound to the cardenolide moiety.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSteroid lactones
Direct ParentCardenolide glycosides and derivatives
Alternative Parents
Substituents
  • Cardanolide-glycoside
  • Steroidal glycoside
  • Oligosaccharide
  • Hydroxysteroid
  • Oxane
  • 2-furanone
  • Alpha,beta-unsaturated carboxylic ester
  • Enoate ester
  • Tertiary alcohol
  • Dihydrofuran
  • Cyclic alcohol
  • Secondary alcohol
  • Lactone
  • Carboxylic acid ester
  • 1,2-diol
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
PharmacodynamicsDigitoxin is a cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current UK medical practice. While there have been several controlled trials which have shown digoxin to be effective in a proportion of patients treated for heart failure, there is not the same strong evidence base for digitoxin, although it is presumed to be similarly effective.
Mechanism of actionDigitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityDigitoxin exhibits similar toxic effects to the more-commonly used digoxin, namely: anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9718
Blood Brain Barrier-0.557
Caco-2 permeable-0.8386
P-glycoprotein substrateSubstrate0.8528
P-glycoprotein inhibitor IInhibitor0.5557
P-glycoprotein inhibitor IINon-inhibitor0.6021
Renal organic cation transporterNon-inhibitor0.8473
CYP450 2C9 substrateNon-substrate0.8687
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.8902
CYP450 2C9 inhibitorNon-inhibitor0.9082
CYP450 2D6 inhibitorNon-inhibitor0.9412
CYP450 2C19 inhibitorNon-inhibitor0.9258
CYP450 3A4 inhibitorNon-inhibitor0.901
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9381
Ames testNon AMES toxic0.9233
CarcinogenicityNon-carcinogens0.9637
BiodegradationNot ready biodegradable0.9671
Rat acute toxicity4.4764 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9812
hERG inhibition (predictor II)Inhibitor0.7759
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral.1 mg
Prices
Unit descriptionCostUnit
Digitoxin powder486.85USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255.5 °CPhysProp
water solubility3.9 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.85SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.0289 mg/mLALOGPS
logP2.33ALOGPS
logP3.6ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)7.18ChemAxon
pKa (Strongest Basic)0.24ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area182.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity191.72 m3·mol-1ChemAxon
Polarizability83.58 Å3ChemAxon
Number of Rings8ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (12.6 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-052g-9620000000-5ddc0df4702d2f0b8581View in MoNA
1D NMR13C NMR SpectrumNot Available
References
Synthesis ReferenceNot Available
General References
  1. Belz GG, Breithaupt-Grogler K, Osowski U: Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7. [PubMed:11525233 ]
  2. Kurowski V, Iven H, Djonlagic H: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies. Intensive Care Med. 1992;18(7):439-42. [PubMed:1469187 ]
  3. Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Claeson P: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. 2001 Jun;12(5):475-83. [PubMed:11395576 ]
  4. Hippius M, Humaid B, Sicker T, Hoffmann A, Gottler M, Hasford J: Adverse drug reaction monitoring--digitoxin overdosage in the elderly. Int J Clin Pharmacol Ther. 2001 Aug;39(8):336-43. [PubMed:11515708 ]
External Links
ATC CodesC01AA04
AHFS Codes
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.4 KB)
Interactions
Drug Interactions
Drug
2-(4-Chlorophenyl)-5-QuinoxalinecarboxamideDigitoxin may decrease the cardiotoxic activities of 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide.
2-MethoxyestradiolDigitoxin may decrease the cardiotoxic activities of 2-Methoxyestradiol.
3-MethoxybenzamideDigitoxin may decrease the cardiotoxic activities of 3-Methoxybenzamide.
3,4-Dihydroxybenzoic AcidDigitoxin may decrease the cardiotoxic activities of 3,4-Dihydroxybenzoic Acid.
5,10-Dideazatetrahydrofolic AcidDigitoxin may decrease the cardiotoxic activities of 5,10-Dideazatetrahydrofolic Acid.
7-HydroxystaurosporineDigitoxin may decrease the cardiotoxic activities of 7-Hydroxystaurosporine.
8-azaguanineDigitoxin may decrease the cardiotoxic activities of 8-azaguanine.
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurineDigitoxin may decrease the cardiotoxic activities of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine.
AbirateroneDigitoxin may decrease the cardiotoxic activities of Abiraterone.
ABT-263Digitoxin may decrease the cardiotoxic activities of ABT-263.
AcebutololAcebutolol may increase the bradycardic activities of Digitoxin.
AcetaminophenThe serum concentration of Digitoxin can be increased when it is combined with Acetaminophen.
AfatinibDigitoxin may decrease the cardiotoxic activities of Afatinib.
AfatinibThe serum concentration of Digitoxin can be increased when it is combined with Afatinib.
AfimoxifeneDigitoxin may decrease the cardiotoxic activities of Afimoxifene.
AfliberceptDigitoxin may decrease the cardiotoxic activities of Aflibercept.
AlatrofloxacinDigitoxin may decrease the cardiotoxic activities of Alatrofloxacin.
AlbendazoleDigitoxin may decrease the cardiotoxic activities of Albendazole.
AlbendazoleThe serum concentration of Digitoxin can be increased when it is combined with Albendazole.
AldesleukinDigitoxin may decrease the cardiotoxic activities of Aldesleukin.
AldosteroneThe serum concentration of Digitoxin can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Digitoxin can be increased when it is combined with Alectinib.
AlemtuzumabDigitoxin may decrease the cardiotoxic activities of Alemtuzumab.
AlfentanilThe serum concentration of Digitoxin can be increased when it is combined with Alfentanil.
AlitretinoinDigitoxin may decrease the cardiotoxic activities of Alitretinoin.
Alpha-DifluoromethylornithineDigitoxin may decrease the cardiotoxic activities of Alpha-Difluoromethylornithine.
AlprenololAlprenolol may increase the bradycardic activities of Digitoxin.
AltretamineDigitoxin may decrease the cardiotoxic activities of Altretamine.
AmantadineThe serum concentration of Digitoxin can be increased when it is combined with Amantadine.
AmikacinThe serum concentration of Digitoxin can be decreased when it is combined with Amikacin.
AmilorideThe therapeutic efficacy of Digitoxin can be decreased when used in combination with Amiloride.
AminoglutethimideDigitoxin may decrease the cardiotoxic activities of Aminoglutethimide.
Aminohippuric acidThe serum concentration of Digitoxin can be increased when it is combined with Aminohippuric acid.
Aminolevulinic acidDigitoxin may decrease the cardiotoxic activities of Aminolevulinic acid.
AmiodaroneThe serum concentration of Digitoxin can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Digitoxin can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Digitoxin can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Digitoxin can be increased when it is combined with Amodiaquine.
AmonafideDigitoxin may decrease the cardiotoxic activities of Amonafide.
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Digitoxin.
AmprenavirThe serum concentration of Digitoxin can be decreased when it is combined with Amprenavir.
AmrubicinDigitoxin may decrease the cardiotoxic activities of Amrubicin.
AmsacrineDigitoxin may decrease the cardiotoxic activities of Amsacrine.
AmsacrineThe serum concentration of Digitoxin can be increased when it is combined with Amsacrine.
AnagrelideDigitoxin may decrease the cardiotoxic activities of Anagrelide.
AnastrozoleDigitoxin may decrease the cardiotoxic activities of Anastrozole.
annamycinDigitoxin may decrease the cardiotoxic activities of annamycin.
AP 12009Digitoxin may decrease the cardiotoxic activities of AP 12009.
AP24534Digitoxin may decrease the cardiotoxic activities of AP24534.
AprepitantThe serum concentration of Digitoxin can be increased when it is combined with Aprepitant.
ArotinololArotinolol may increase the bradycardic activities of Digitoxin.
Arsenic trioxideDigitoxin may decrease the cardiotoxic activities of Arsenic trioxide.
ASA404Digitoxin may decrease the cardiotoxic activities of ASA404.
AsparaginaseDigitoxin may decrease the cardiotoxic activities of Asparaginase.
AstemizoleThe serum concentration of Digitoxin can be increased when it is combined with Astemizole.
AT-101Digitoxin may decrease the cardiotoxic activities of AT-101.
AtazanavirThe serum concentration of Digitoxin can be increased when it is combined with Atazanavir.
AtenololAtenolol may increase the bradycardic activities of Digitoxin.
AtomoxetineThe metabolism of Digitoxin can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Digitoxin can be increased when it is combined with Atorvastatin.
AxitinibDigitoxin may decrease the cardiotoxic activities of Axitinib.
AzacitidineDigitoxin may decrease the cardiotoxic activities of Azacitidine.
AzathioprineDigitoxin may decrease the cardiotoxic activities of Azathioprine.
AZD2171Digitoxin may decrease the cardiotoxic activities of AZD2171.
Azelaic AcidDigitoxin may decrease the cardiotoxic activities of Azelaic Acid.
AzelastineThe serum concentration of Digitoxin can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Digitoxin can be increased when it is combined with Azithromycin.
BalsalazideThe serum concentration of Digitoxin can be decreased when it is combined with Balsalazide.
BatimastatDigitoxin may decrease the cardiotoxic activities of Batimastat.
BefunololBefunolol may increase the bradycardic activities of Digitoxin.
BelinostatDigitoxin may decrease the cardiotoxic activities of Belinostat.
BendamustineDigitoxin may decrease the cardiotoxic activities of Bendamustine.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Digitoxin.
BenzocaineThe serum concentration of Digitoxin can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Digitoxin can be increased when it is combined with Bepridil.
BesifloxacinDigitoxin may decrease the cardiotoxic activities of Besifloxacin.
BetaxololBetaxolol may increase the bradycardic activities of Digitoxin.
BevacizumabDigitoxin may decrease the cardiotoxic activities of Bevacizumab.
BevantololBevantolol may increase the bradycardic activities of Digitoxin.
BexaroteneDigitoxin may decrease the cardiotoxic activities of Bexarotene.
BexaroteneThe serum concentration of Digitoxin can be decreased when it is combined with Bexarotene.
BicalutamideDigitoxin may decrease the cardiotoxic activities of Bicalutamide.
BiperidenThe serum concentration of Digitoxin can be increased when it is combined with Biperiden.
BisoprololBisoprolol may increase the bradycardic activities of Digitoxin.
BleomycinDigitoxin may decrease the cardiotoxic activities of Bleomycin.
BlinatumomabDigitoxin may decrease the cardiotoxic activities of Blinatumomab.
BoceprevirThe metabolism of Digitoxin can be decreased when combined with Boceprevir.
BopindololBopindolol may increase the bradycardic activities of Digitoxin.
BortezomibDigitoxin may decrease the cardiotoxic activities of Bortezomib.
BortezomibThe metabolism of Digitoxin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Digitoxin can be decreased when it is combined with Bosentan.
BosutinibDigitoxin may decrease the cardiotoxic activities of Bosutinib.
BosutinibThe serum concentration of Digitoxin can be increased when it is combined with Bosutinib.
Brentuximab vedotinDigitoxin may decrease the cardiotoxic activities of Brentuximab vedotin.
BromocriptineThe serum concentration of Digitoxin can be increased when it is combined with Bromocriptine.
BSI-201Digitoxin may decrease the cardiotoxic activities of BSI-201.
BufuralolBufuralol may increase the bradycardic activities of Digitoxin.
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Digitoxin.
BupranololBupranolol may increase the bradycardic activities of Digitoxin.
BuprenorphineThe serum concentration of Digitoxin can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Digitoxin can be increased when it is combined with Buspirone.
BusulfanDigitoxin may decrease the cardiotoxic activities of Busulfan.
CabazitaxelDigitoxin may decrease the cardiotoxic activities of Cabazitaxel.
CabazitaxelThe serum concentration of Digitoxin can be increased when it is combined with Cabazitaxel.
CabergolineDigitoxin may decrease the cardiotoxic activities of Cabergoline.
CabozantinibDigitoxin may decrease the cardiotoxic activities of Cabozantinib.
CaffeineThe serum concentration of Digitoxin can be increased when it is combined with Caffeine.
CalcipotriolDigitoxin may decrease the cardiotoxic activities of Calcipotriol.
CamptothecinDigitoxin may decrease the cardiotoxic activities of Camptothecin.
CanagliflozinThe serum concentration of Digitoxin can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Digitoxin can be increased when it is combined with Candesartan.
CapecitabineDigitoxin may decrease the cardiotoxic activities of Capecitabine.
CaptoprilThe serum concentration of Digitoxin can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Digitoxin can be decreased when it is combined with Carbamazepine.
CarbimazoleThe serum concentration of Digitoxin can be increased when it is combined with Carbimazole.
CarboplatinDigitoxin may decrease the cardiotoxic activities of Carboplatin.
CarfilzomibDigitoxin may decrease the cardiotoxic activities of Carfilzomib.
CarmofurDigitoxin may decrease the cardiotoxic activities of Carmofur.
CarmustineDigitoxin may decrease the cardiotoxic activities of Carmustine.
CarteololCarteolol may increase the bradycardic activities of Digitoxin.
CarvedilolCarvedilol may increase the bradycardic activities of Digitoxin.
CaspofunginThe serum concentration of Digitoxin can be increased when it is combined with Caspofungin.
CatumaxomabDigitoxin may decrease the cardiotoxic activities of Catumaxomab.
CB1954Digitoxin may decrease the cardiotoxic activities of CB1954.
CelecoxibDigitoxin may decrease the cardiotoxic activities of Celecoxib.
CeliprololCeliprolol may increase the bradycardic activities of Digitoxin.
CeritinibThe serum concentration of Digitoxin can be increased when it is combined with Ceritinib.
CeritinibDigitoxin may decrease the cardiotoxic activities of Ceritinib.
CetuximabDigitoxin may decrease the cardiotoxic activities of Cetuximab.
ChlorambucilDigitoxin may decrease the cardiotoxic activities of Chlorambucil.
ChloroquineThe serum concentration of Digitoxin can be increased when it is combined with Chloroquine.
ChlorothiazideThe risk or severity of adverse effects can be increased when Chlorothiazide is combined with Digitoxin.
ChlorotrianiseneDigitoxin may decrease the cardiotoxic activities of Chlorotrianisene.
ChlorpromazineThe serum concentration of Digitoxin can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Digitoxin can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Digitoxin can be increased when it is combined with Chlorprothixene.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digitoxin.
CholesterolThe serum concentration of Digitoxin can be increased when it is combined with Cholesterol.
CholestyramineCholestyramine can cause a decrease in the absorption of Digitoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic AcidThe serum concentration of Digitoxin can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Digitoxin can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Digitoxin can be decreased when it is combined with Cimetidine.
CinoxacinDigitoxin may decrease the cardiotoxic activities of Cinoxacin.
CiprofloxacinDigitoxin may decrease the cardiotoxic activities of Ciprofloxacin.
CiprofloxacinThe serum concentration of Digitoxin can be increased when it is combined with Ciprofloxacin.
CisplatinDigitoxin may decrease the cardiotoxic activities of Cisplatin.
CitalopramThe serum concentration of Digitoxin can be increased when it is combined with Citalopram.
CladribineDigitoxin may decrease the cardiotoxic activities of Cladribine.
ClarithromycinThe serum concentration of Digitoxin can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Digitoxin can be decreased when combined with Clemastine.
ClofarabineDigitoxin may decrease the cardiotoxic activities of Clofarabine.
ClofazimineThe serum concentration of Digitoxin can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Digitoxin can be increased when it is combined with Clomipramine.
ClonidineClonidine may increase the atrioventricular blocking (AV block) activities of Digitoxin.
ClotrimazoleThe metabolism of Digitoxin can be decreased when combined with Clotrimazole.
CobicistatThe serum concentration of Digitoxin can be increased when it is combined with Cobicistat.
ColchicineDigitoxin may decrease the cardiotoxic activities of Colchicine.
ColchicineThe serum concentration of Digitoxin can be increased when it is combined with Colchicine.
ColesevelamColesevelam can cause a decrease in the absorption of Digitoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColestipolColestipol can cause a decrease in the absorption of Digitoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColforsinThe serum concentration of Digitoxin can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Digitoxin can be increased when it is combined with Conivaptan.
CrizotinibDigitoxin may decrease the cardiotoxic activities of Crizotinib.
CrizotinibThe metabolism of Digitoxin can be decreased when combined with Crizotinib.
CyclophosphamideDigitoxin may decrease the cardiotoxic activities of Cyclophosphamide.
CyclophosphamideThe serum concentration of Digitoxin can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Digitoxin can be decreased when combined with Cyclosporine.
Cyproterone acetateDigitoxin may decrease the cardiotoxic activities of Cyproterone acetate.
CytarabineDigitoxin may decrease the cardiotoxic activities of Cytarabine.
DabrafenibDigitoxin may decrease the cardiotoxic activities of Dabrafenib.
DabrafenibThe serum concentration of Digitoxin can be decreased when it is combined with Dabrafenib.
DacarbazineDigitoxin may decrease the cardiotoxic activities of Dacarbazine.
DaclatasvirThe serum concentration of Digitoxin can be increased when it is combined with Daclatasvir.
DactinomycinDigitoxin may decrease the cardiotoxic activities of Dactinomycin.
DactinomycinThe serum concentration of Digitoxin can be increased when it is combined with Dactinomycin.
DaratumumabDigitoxin may decrease the cardiotoxic activities of Daratumumab.
DarunavirThe metabolism of Digitoxin can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Digitoxin can be increased when it is combined with Dasatinib.
DasatinibDigitoxin may decrease the cardiotoxic activities of Dasatinib.
DaunorubicinDigitoxin may decrease the cardiotoxic activities of Daunorubicin.
DaunorubicinThe serum concentration of Digitoxin can be decreased when it is combined with Daunorubicin.
DecitabineDigitoxin may decrease the cardiotoxic activities of Decitabine.
DeferasiroxThe serum concentration of Digitoxin can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Digitoxin can be decreased when combined with Delavirdine.
Denileukin diftitoxDigitoxin may decrease the cardiotoxic activities of Denileukin diftitox.
DesipramineThe serum concentration of Digitoxin can be increased when it is combined with Desipramine.
DesloratadineThe serum concentration of Digitoxin can be increased when it is combined with Desloratadine.
DexamethasoneDigitoxin may decrease the cardiotoxic activities of Dexamethasone.
DexamethasoneThe serum concentration of Digitoxin can be decreased when it is combined with Dexamethasone.
DexrazoxaneDigitoxin may decrease the cardiotoxic activities of Dexrazoxane.
DextromethorphanThe serum concentration of Digitoxin can be increased when it is combined with Dextromethorphan.
DiclofenacThe serum concentration of Digitoxin can be increased when it is combined with Diclofenac.
DienogestDigitoxin may decrease the cardiotoxic activities of Dienogest.
DiethylstilbestrolDigitoxin may decrease the cardiotoxic activities of Diethylstilbestrol.
DigoxinThe serum concentration of Digitoxin can be decreased when it is combined with Digoxin.
DihydroergotamineThe metabolism of Digitoxin can be decreased when combined with Dihydroergotamine.
DihydrostreptomycinThe serum concentration of Digitoxin can be decreased when it is combined with Dihydrostreptomycin.
DiltiazemThe metabolism of Digitoxin can be decreased when combined with Diltiazem.
DinutuximabDigitoxin may decrease the cardiotoxic activities of Dinutuximab.
DipyridamoleThe serum concentration of Digitoxin can be increased when it is combined with Dipyridamole.
DocetaxelDigitoxin may decrease the cardiotoxic activities of Docetaxel.
DoxazosinThe serum concentration of Digitoxin can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Digitoxin can be increased when it is combined with Doxepin.
DoxorubicinDigitoxin may decrease the cardiotoxic activities of Doxorubicin.
DoxorubicinThe serum concentration of Digitoxin can be decreased when it is combined with Doxorubicin.
DoxycyclineThe metabolism of Digitoxin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Digitoxin can be increased when it is combined with Dronabinol.
DronedaroneThe metabolism of Digitoxin can be decreased when combined with Dronedarone.
EcabetDigitoxin may decrease the cardiotoxic activities of Ecabet.
EdrophoniumEdrophonium may increase the atrioventricular blocking (AV block) activities of Digitoxin.
efaproxiralDigitoxin may decrease the cardiotoxic activities of efaproxiral.
EfavirenzThe serum concentration of Digitoxin can be decreased when it is combined with Efavirenz.
EflornithineDigitoxin may decrease the cardiotoxic activities of Eflornithine.
EG009Digitoxin may decrease the cardiotoxic activities of EG009.
ElbasvirThe serum concentration of Digitoxin can be increased when it is combined with Elbasvir.
ElsamitrucinDigitoxin may decrease the cardiotoxic activities of Elsamitrucin.
EnalaprilThe serum concentration of Digitoxin can be increased when it is combined with Enalapril.
EndostatinDigitoxin may decrease the cardiotoxic activities of Endostatin.
EnoxacinDigitoxin may decrease the cardiotoxic activities of Enoxacin.
EnrofloxacinDigitoxin may decrease the cardiotoxic activities of Enrofloxacin.
EnzalutamideThe serum concentration of Digitoxin can be increased when it is combined with Enzalutamide.
EpirubicinDigitoxin may decrease the cardiotoxic activities of Epirubicin.
EpirubicinThe serum concentration of Digitoxin can be decreased when it is combined with Epirubicin.
EplerenoneThe therapeutic efficacy of Digitoxin can be decreased when used in combination with Eplerenone.
Epothilone BDigitoxin may decrease the cardiotoxic activities of Epothilone B.
ErgonovineThe serum concentration of Digitoxin can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Digitoxin can be increased when it is combined with Ergotamine.
EribulinDigitoxin may decrease the cardiotoxic activities of Eribulin.
ErlotinibDigitoxin may decrease the cardiotoxic activities of Erlotinib.
ErythromycinThe metabolism of Digitoxin can be decreased when combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Digitoxin can be decreased when it is combined with Eslicarbazepine acetate.
EsmololEsmolol may increase the bradycardic activities of Digitoxin.
EstramustineDigitoxin may decrease the cardiotoxic activities of Estramustine.
EstramustineThe serum concentration of Digitoxin can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Digitoxin can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Digitoxin can be decreased when it is combined with Estrone.
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Digitoxin.
Ethiodized oilDigitoxin may decrease the cardiotoxic activities of Ethiodized oil.
Ethyl carbamateDigitoxin may decrease the cardiotoxic activities of Ethyl carbamate.
EtoposideDigitoxin may decrease the cardiotoxic activities of Etoposide.
EtoposideThe serum concentration of Digitoxin can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Digitoxin can be decreased when it is combined with Etravirine.
EverolimusDigitoxin may decrease the cardiotoxic activities of Everolimus.
ExemestaneDigitoxin may decrease the cardiotoxic activities of Exemestane.
exisulindDigitoxin may decrease the cardiotoxic activities of exisulind.
FelodipineThe serum concentration of Digitoxin can be increased when it is combined with Felodipine.
FenretinideDigitoxin may decrease the cardiotoxic activities of Fenretinide.
FentanylThe serum concentration of Digitoxin can be increased when it is combined with Fentanyl.
FexofenadineThe serum concentration of Digitoxin can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Digitoxin can be increased when it is combined with Fidaxomicin.
FlavopiridolDigitoxin may decrease the cardiotoxic activities of Flavopiridol.
FleroxacinDigitoxin may decrease the cardiotoxic activities of Fleroxacin.
FloxuridineDigitoxin may decrease the cardiotoxic activities of Floxuridine.
FluconazoleThe metabolism of Digitoxin can be decreased when combined with Fluconazole.
FludarabineDigitoxin may decrease the cardiotoxic activities of Fludarabine.
FlumequineDigitoxin may decrease the cardiotoxic activities of Flumequine.
FluorouracilDigitoxin may decrease the cardiotoxic activities of Fluorouracil.
FluoxetineThe serum concentration of Digitoxin can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Digitoxin can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Digitoxin can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Digitoxin can be increased when it is combined with Flurazepam.
FlutamideDigitoxin may decrease the cardiotoxic activities of Flutamide.
FluvoxamineThe metabolism of Digitoxin can be decreased when combined with Fluvoxamine.
FormestaneDigitoxin may decrease the cardiotoxic activities of Formestane.
FormycinDigitoxin may decrease the cardiotoxic activities of Formycin.
FosamprenavirThe metabolism of Digitoxin can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Digitoxin can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Digitoxin can be increased when combined with Fosphenytoin.
FotemustineDigitoxin may decrease the cardiotoxic activities of Fotemustine.
FramycetinThe serum concentration of Digitoxin can be decreased when it is combined with Framycetin.
FulvestrantDigitoxin may decrease the cardiotoxic activities of Fulvestrant.
FumagillinDigitoxin may decrease the cardiotoxic activities of Fumagillin.
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Digitoxin.
Fusidic AcidThe serum concentration of Digitoxin can be increased when it is combined with Fusidic Acid.
Gallium nitrateDigitoxin may decrease the cardiotoxic activities of Gallium nitrate.
GarenoxacinDigitoxin may decrease the cardiotoxic activities of Garenoxacin.
GatifloxacinDigitoxin may decrease the cardiotoxic activities of Gatifloxacin.
GefitinibDigitoxin may decrease the cardiotoxic activities of Gefitinib.
GefitinibThe serum concentration of Digitoxin can be increased when it is combined with Gefitinib.
GeldanamycinDigitoxin may decrease the cardiotoxic activities of Geldanamycin.
GemcitabineDigitoxin may decrease the cardiotoxic activities of Gemcitabine.
GemifloxacinDigitoxin may decrease the cardiotoxic activities of Gemifloxacin.
Gemtuzumab ozogamicinDigitoxin may decrease the cardiotoxic activities of Gemtuzumab ozogamicin.
GenisteinDigitoxin may decrease the cardiotoxic activities of Genistein.
GenisteinThe serum concentration of Digitoxin can be increased when it is combined with Genistein.
GentamicinThe serum concentration of Digitoxin can be decreased when it is combined with Gentamicin.
Ginsenoside CDigitoxin may decrease the cardiotoxic activities of Ginsenoside C.
GlyburideThe serum concentration of Digitoxin can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Digitoxin can be increased when it is combined with Glycerol.
GoserelinDigitoxin may decrease the cardiotoxic activities of Goserelin.
Gramicidin DThe serum concentration of Digitoxin can be increased when it is combined with Gramicidin D.
GrepafloxacinDigitoxin may decrease the cardiotoxic activities of Grepafloxacin.
GrepafloxacinThe serum concentration of Digitoxin can be increased when it is combined with Grepafloxacin.
HadacidinDigitoxin may decrease the cardiotoxic activities of Hadacidin.
HalofuginoneDigitoxin may decrease the cardiotoxic activities of Halofuginone.
HaloperidolThe serum concentration of Digitoxin can be increased when it is combined with Haloperidol.
HexestrolDigitoxin may decrease the cardiotoxic activities of Hexestrol.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Digitoxin.
HydrocortisoneThe serum concentration of Digitoxin can be increased when it is combined with Hydrocortisone.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Hydroflumethiazide is combined with Digitoxin.
HydroxychloroquineThe serum concentration of Digitoxin can be increased when it is combined with Hydroxychloroquine.
Hydroxyprogesterone caproateDigitoxin may decrease the cardiotoxic activities of Hydroxyprogesterone caproate.
HydroxyureaDigitoxin may decrease the cardiotoxic activities of Hydroxyurea.
Hygromycin BThe serum concentration of Digitoxin can be decreased when it is combined with Hygromycin B.
IbrutinibDigitoxin may decrease the cardiotoxic activities of Ibrutinib.
IdarubicinDigitoxin may decrease the cardiotoxic activities of Idarubicin.
IdarubicinThe serum concentration of Digitoxin can be decreased when it is combined with Idarubicin.
IdelalisibThe serum concentration of Digitoxin can be increased when it is combined with Idelalisib.
IdelalisibDigitoxin may decrease the cardiotoxic activities of Idelalisib.
IfosfamideDigitoxin may decrease the cardiotoxic activities of Ifosfamide.
ImatinibDigitoxin may decrease the cardiotoxic activities of Imatinib.
ImatinibThe metabolism of Digitoxin can be decreased when combined with Imatinib.
ImipramineThe serum concentration of Digitoxin can be increased when it is combined with Imipramine.
ImiquimodDigitoxin may decrease the cardiotoxic activities of Imiquimod.
IndapamideThe risk or severity of adverse effects can be increased when Indapamide is combined with Digitoxin.
IndenololIndenolol may increase the bradycardic activities of Digitoxin.
IndinavirThe serum concentration of Digitoxin can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Digitoxin can be increased when it is combined with Indomethacin.
Interferon beta-1aDigitoxin may decrease the cardiotoxic activities of Interferon beta-1a.
IobenguaneDigitoxin may decrease the cardiotoxic activities of Iobenguane.
IpilimumabDigitoxin may decrease the cardiotoxic activities of Ipilimumab.
IrinotecanDigitoxin may decrease the cardiotoxic activities of Irinotecan.
IsavuconazoniumThe metabolism of Digitoxin can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Digitoxin can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Digitoxin can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Digitoxin can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Digitoxin can be increased when it is combined with Ivermectin.
IxabepiloneDigitoxin may decrease the cardiotoxic activities of Ixabepilone.
IxazomibDigitoxin may decrease the cardiotoxic activities of Ixazomib.
KanamycinThe serum concentration of Digitoxin can be decreased when it is combined with Kanamycin.
KaolinThe serum concentration of Digitoxin can be decreased when it is combined with Kaolin.
KetamineThe serum concentration of Digitoxin can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Digitoxin can be increased when it is combined with Ketoconazole.
KOS-1584Digitoxin may decrease the cardiotoxic activities of KOS-1584.
L-alanosineDigitoxin may decrease the cardiotoxic activities of L-alanosine.
LabetalolLabetalol may increase the bradycardic activities of Digitoxin.
LanreotideDigitoxin may decrease the cardiotoxic activities of Lanreotide.
LansoprazoleThe serum concentration of Digitoxin can be increased when it is combined with Lansoprazole.
LapatinibDigitoxin may decrease the cardiotoxic activities of Lapatinib.
LapatinibThe serum concentration of Digitoxin can be increased when it is combined with Lapatinib.
LeflunomideDigitoxin may decrease the cardiotoxic activities of Leflunomide.
LenalidomideDigitoxin may decrease the cardiotoxic activities of Lenalidomide.
LenvatinibDigitoxin may decrease the cardiotoxic activities of Lenvatinib.
LetrozoleDigitoxin may decrease the cardiotoxic activities of Letrozole.
LeuprolideDigitoxin may decrease the cardiotoxic activities of Leuprolide.
LevobunololLevobunolol may increase the bradycardic activities of Digitoxin.
LevofloxacinDigitoxin may decrease the cardiotoxic activities of Levofloxacin.
LevofloxacinThe serum concentration of Digitoxin can be increased when it is combined with Levofloxacin.
LevothyroxineThe serum concentration of Digitoxin can be decreased when it is combined with Levothyroxine.
LicoriceThe risk or severity of adverse effects can be increased when Licorice is combined with Digitoxin.
LidocaineThe serum concentration of Digitoxin can be increased when it is combined with Lidocaine.
LiothyronineThe serum concentration of Digitoxin can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Digitoxin can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Digitoxin can be increased when it is combined with Lisinopril.
LomefloxacinDigitoxin may decrease the cardiotoxic activities of Lomefloxacin.
LomitapideThe serum concentration of Digitoxin can be increased when it is combined with Lomitapide.
LomustineDigitoxin may decrease the cardiotoxic activities of Lomustine.
LonidamineDigitoxin may decrease the cardiotoxic activities of Lonidamine.
LoperamideThe serum concentration of Digitoxin can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Digitoxin can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Digitoxin can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Digitoxin can be increased when it is combined with Losartan.
LovastatinThe metabolism of Digitoxin can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Digitoxin can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Digitoxin can be decreased when it is combined with Lumacaftor.
LycopeneDigitoxin may decrease the cardiotoxic activities of Lycopene.
MaprotilineThe serum concentration of Digitoxin can be increased when it is combined with Maprotiline.
MasitinibDigitoxin may decrease the cardiotoxic activities of Masitinib.
MasoprocolDigitoxin may decrease the cardiotoxic activities of Masoprocol.
MaxacalcitolDigitoxin may decrease the cardiotoxic activities of Maxacalcitol.
MDX-1106Digitoxin may decrease the cardiotoxic activities of MDX-1106.
MebendazoleDigitoxin may decrease the cardiotoxic activities of Mebendazole.
MebendazoleThe serum concentration of Digitoxin can be increased when it is combined with Mebendazole.
MechlorethamineDigitoxin may decrease the cardiotoxic activities of Mechlorethamine.
MedrogestoneDigitoxin may decrease the cardiotoxic activities of Medrogestone.
Medroxyprogesterone acetateDigitoxin may decrease the cardiotoxic activities of Medroxyprogesterone acetate.
MefloquineThe serum concentration of Digitoxin can be increased when it is combined with Mefloquine.
Megestrol acetateDigitoxin may decrease the cardiotoxic activities of Megestrol acetate.
Megestrol acetateThe serum concentration of Digitoxin can be increased when it is combined with Megestrol acetate.
MelphalanDigitoxin may decrease the cardiotoxic activities of Melphalan.
MeprobamateThe serum concentration of Digitoxin can be increased when it is combined with Meprobamate.
MequinolDigitoxin may decrease the cardiotoxic activities of Mequinol.
MercaptopurineDigitoxin may decrease the cardiotoxic activities of Mercaptopurine.
MesalazineThe serum concentration of Digitoxin can be decreased when it is combined with Mesalazine.
MethadoneThe serum concentration of Digitoxin can be increased when it is combined with Methadone.
MethimazoleThe serum concentration of Digitoxin can be increased when it is combined with Methimazole.
MethotrexateDigitoxin may decrease the cardiotoxic activities of Methotrexate.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Digitoxin.
Methyl aminolevulinateDigitoxin may decrease the cardiotoxic activities of Methyl aminolevulinate.
MethylprednisoloneDigitoxin may decrease the cardiotoxic activities of Methylprednisolone.
MethyltestosteroneDigitoxin may decrease the cardiotoxic activities of Methyltestosterone.
MetipranololMetipranolol may increase the bradycardic activities of Digitoxin.
MetolazoneThe risk or severity of adverse effects can be increased when Metolazone is combined with Digitoxin.
MetoprololMetoprolol may increase the bradycardic activities of Digitoxin.
MetrizamideThe serum concentration of Digitoxin can be decreased when it is combined with Metrizamide.
MGI-114Digitoxin may decrease the cardiotoxic activities of MGI-114.
MibefradilThe serum concentration of Digitoxin can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Digitoxin can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Digitoxin can be decreased when it is combined with Midazolam.
MidodrineDigitoxin may increase the bradycardic activities of Midodrine.
MidostaurinDigitoxin may decrease the cardiotoxic activities of Midostaurin.
MifepristoneThe metabolism of Digitoxin can be decreased when combined with Mifepristone.
MiltefosineDigitoxin may decrease the cardiotoxic activities of Miltefosine.
MitomycinDigitoxin may decrease the cardiotoxic activities of Mitomycin.
MitomycinThe serum concentration of Digitoxin can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Digitoxin can be decreased when it is combined with Mitotane.
MitotaneDigitoxin may decrease the cardiotoxic activities of Mitotane.
MitoxantroneDigitoxin may decrease the cardiotoxic activities of Mitoxantrone.
MitoxantroneThe serum concentration of Digitoxin can be decreased when it is combined with Mitoxantrone.
ModafinilThe serum concentration of Digitoxin can be decreased when it is combined with Modafinil.
MorphineThe serum concentration of Digitoxin can be increased when it is combined with Morphine.
motexafin gadoliniumDigitoxin may decrease the cardiotoxic activities of motexafin gadolinium.
MoxifloxacinDigitoxin may decrease the cardiotoxic activities of Moxifloxacin.
Mycophenolic acidDigitoxin may decrease the cardiotoxic activities of Mycophenolic acid.
NadololNadolol may increase the bradycardic activities of Digitoxin.
NafcillinThe serum concentration of Digitoxin can be decreased when it is combined with Nafcillin.
Nalidixic AcidDigitoxin may decrease the cardiotoxic activities of Nalidixic Acid.
NaltrexoneThe serum concentration of Digitoxin can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Digitoxin can be increased when it is combined with Naringenin.
NecitumumabDigitoxin may decrease the cardiotoxic activities of Necitumumab.
NefazodoneThe serum concentration of Digitoxin can be decreased when it is combined with Nefazodone.
NelarabineDigitoxin may decrease the cardiotoxic activities of Nelarabine.
NelfinavirThe serum concentration of Digitoxin can be decreased when it is combined with Nelfinavir.
NeomycinThe serum concentration of Digitoxin can be decreased when it is combined with Neomycin.
NeostigmineThe serum concentration of Digitoxin can be increased when it is combined with Neostigmine.
NetilmicinThe serum concentration of Digitoxin can be decreased when it is combined with Netilmicin.
NetupitantThe serum concentration of Digitoxin can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Digitoxin can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Digitoxin can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Digitoxin can be decreased when it is combined with Nifedipine.
NiguldipineDigitoxin may decrease the cardiotoxic activities of Niguldipine.
NilotinibDigitoxin may decrease the cardiotoxic activities of Nilotinib.
NilotinibThe metabolism of Digitoxin can be decreased when combined with Nilotinib.
NilutamideDigitoxin may decrease the cardiotoxic activities of Nilutamide.
NintedanibDigitoxin may decrease the cardiotoxic activities of Nintedanib.
NisoldipineThe serum concentration of Digitoxin can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Digitoxin can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Digitoxin can be increased when it is combined with Nitrendipine.
NivolumabDigitoxin may decrease the cardiotoxic activities of Nivolumab.
nocodazoleDigitoxin may decrease the cardiotoxic activities of nocodazole.
NorethisteroneThe serum concentration of Digitoxin can be decreased when it is combined with Norethisterone.
NorfloxacinDigitoxin may decrease the cardiotoxic activities of Norfloxacin.
ObinutuzumabDigitoxin may decrease the cardiotoxic activities of Obinutuzumab.
OctreotideDigitoxin may decrease the cardiotoxic activities of Octreotide.
OfatumumabDigitoxin may decrease the cardiotoxic activities of Ofatumumab.
OfloxacinDigitoxin may decrease the cardiotoxic activities of Ofloxacin.
OlaparibDigitoxin may decrease the cardiotoxic activities of Olaparib.
OlaparibThe metabolism of Digitoxin can be decreased when combined with Olaparib.
OlsalazineThe serum concentration of Digitoxin can be decreased when it is combined with Olsalazine.
Omacetaxine mepesuccinateDigitoxin may decrease the cardiotoxic activities of Omacetaxine mepesuccinate.
OmeprazoleThe serum concentration of Digitoxin can be increased when it is combined with Omeprazole.
OprelvekinDigitoxin may decrease the cardiotoxic activities of Oprelvekin.
OsimertinibThe serum concentration of Digitoxin can be increased when it is combined with Osimertinib.
OsimertinibDigitoxin may decrease the cardiotoxic activities of Osimertinib.
OxaliplatinDigitoxin may decrease the cardiotoxic activities of Oxaliplatin.
OxprenololOxprenolol may increase the bradycardic activities of Digitoxin.
P-NitrophenolThe serum concentration of Digitoxin can be increased when it is combined with P-Nitrophenol.
PaclitaxelDigitoxin may decrease the cardiotoxic activities of Paclitaxel.
PaclitaxelThe serum concentration of Digitoxin can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Digitoxin can be increased when it is combined with Palbociclib.
PalbociclibDigitoxin may decrease the cardiotoxic activities of Palbociclib.
PalifosfamideDigitoxin may decrease the cardiotoxic activities of Palifosfamide.
Palmitic AcidThe serum concentration of Digitoxin can be increased when it is combined with Palmitic Acid.
PamidronateDigitoxin may decrease the cardiotoxic activities of Pamidronate.
PanitumumabDigitoxin may decrease the cardiotoxic activities of Panitumumab.
PanobinostatDigitoxin may decrease the cardiotoxic activities of Panobinostat.
PantoprazoleThe serum concentration of Digitoxin can be increased when it is combined with Pantoprazole.
Parathyroid hormoneThe risk or severity of adverse effects can be increased when Parathyroid hormone is combined with Digitoxin.
ParomomycinThe serum concentration of Digitoxin can be decreased when it is combined with Paromomycin.
ParoxetineThe serum concentration of Digitoxin can be increased when it is combined with Paroxetine.
PazopanibDigitoxin may decrease the cardiotoxic activities of Pazopanib.
PefloxacinDigitoxin may decrease the cardiotoxic activities of Pefloxacin.
PegaspargaseDigitoxin may decrease the cardiotoxic activities of Pegaspargase.
PembrolizumabDigitoxin may decrease the cardiotoxic activities of Pembrolizumab.
PemetrexedDigitoxin may decrease the cardiotoxic activities of Pemetrexed.
PenbutololPenbutolol may increase the bradycardic activities of Digitoxin.
PentobarbitalThe metabolism of Digitoxin can be increased when combined with Pentobarbital.
PentostatinDigitoxin may decrease the cardiotoxic activities of Pentostatin.
PerindoprilThe serum concentration of Digitoxin can be increased when it is combined with Perindopril.
PertuzumabDigitoxin may decrease the cardiotoxic activities of Pertuzumab.
PhenobarbitalThe serum concentration of Digitoxin can be decreased when it is combined with Phenobarbital.
Phenylacetic acidDigitoxin may decrease the cardiotoxic activities of Phenylacetic acid.
PhenytoinThe metabolism of Digitoxin can be increased when combined with Phenytoin.
PimozideThe serum concentration of Digitoxin can be increased when it is combined with Pimozide.
PindololPindolol may increase the bradycardic activities of Digitoxin.
PipobromanDigitoxin may decrease the cardiotoxic activities of Pipobroman.
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Digitoxin.
PirfenidoneDigitoxin may decrease the cardiotoxic activities of Pirfenidone.
PirlindoleDigitoxin may decrease the cardiotoxic activities of Pirlindole.
PixantroneDigitoxin may decrease the cardiotoxic activities of Pixantrone.
Platelet Activating FactorThe serum concentration of Digitoxin can be decreased when it is combined with Platelet Activating Factor.
PlicamycinDigitoxin may decrease the cardiotoxic activities of Plicamycin.
PlicamycinThe serum concentration of Digitoxin can be decreased when it is combined with Plicamycin.
PodofiloxDigitoxin may decrease the cardiotoxic activities of Podofilox.
PodophyllinDigitoxin may decrease the cardiotoxic activities of Podophyllin.
polyacrylic acidDigitoxin may decrease the cardiotoxic activities of polyacrylic acid.
Polystyrene sulfonateThe risk or severity of adverse effects can be increased when Polystyrene sulfonate is combined with Digitoxin.
PolythiazideThe risk or severity of adverse effects can be increased when Polythiazide is combined with Digitoxin.
PomalidomideDigitoxin may decrease the cardiotoxic activities of Pomalidomide.
PonatinibDigitoxin may decrease the cardiotoxic activities of Ponatinib.
PonatinibThe serum concentration of Digitoxin can be increased when it is combined with Ponatinib.
PorfimerDigitoxin may decrease the cardiotoxic activities of Porfimer.
porfiromycinDigitoxin may decrease the cardiotoxic activities of porfiromycin.
PosaconazoleThe serum concentration of Digitoxin can be increased when it is combined with Posaconazole.
PractololPractolol may increase the bradycardic activities of Digitoxin.
PralatrexateDigitoxin may decrease the cardiotoxic activities of Pralatrexate.
PravastatinThe serum concentration of Digitoxin can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Digitoxin can be increased when it is combined with Prazosin.
PrednisoloneDigitoxin may decrease the cardiotoxic activities of Prednisolone.
PrednisoneDigitoxin may decrease the cardiotoxic activities of Prednisone.
PrednisoneThe serum concentration of Digitoxin can be increased when it is combined with Prednisone.
PrimaquineThe serum concentration of Digitoxin can be increased when it is combined with Primaquine.
PrimidoneThe metabolism of Digitoxin can be increased when combined with Primidone.
ProbenecidThe serum concentration of Digitoxin can be increased when it is combined with Probenecid.
ProcarbazineDigitoxin may decrease the cardiotoxic activities of Procarbazine.
ProgesteroneThe serum concentration of Digitoxin can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Digitoxin can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Digitoxin can be increased when it is combined with Propafenone.
PropranololPropranolol may increase the bradycardic activities of Digitoxin.
PropylthiouracilThe serum concentration of Digitoxin can be increased when it is combined with Propylthiouracil.
ProtriptylineThe serum concentration of Digitoxin can be increased when it is combined with Protriptyline.
Purine RibosideDigitoxin may decrease the cardiotoxic activities of Purine Riboside.
PuromycinDigitoxin may decrease the cardiotoxic activities of Puromycin.
PuromycinThe serum concentration of Digitoxin can be decreased when it is combined with Puromycin.
QuercetinThe serum concentration of Digitoxin can be increased when it is combined with Quercetin.
QuinacrineDigitoxin may decrease the cardiotoxic activities of Quinacrine.
QuinacrineThe serum concentration of Digitoxin can be increased when it is combined with Quinacrine.
QuinethazoneThe risk or severity of adverse effects can be increased when Quinethazone is combined with Digitoxin.
QuinidineThe serum concentration of Digitoxin can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Digitoxin can be increased when it is combined with Quinine.
Radium Ra 223 DichlorideDigitoxin may decrease the cardiotoxic activities of Radium Ra 223 Dichloride.
RaltitrexedDigitoxin may decrease the cardiotoxic activities of Raltitrexed.
RamucirumabDigitoxin may decrease the cardiotoxic activities of Ramucirumab.
RanibizumabDigitoxin may decrease the cardiotoxic activities of Ranibizumab.
RanitidineThe serum concentration of Digitoxin can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Digitoxin can be increased when it is combined with Ranolazine.
RanpirnaseDigitoxin may decrease the cardiotoxic activities of Ranpirnase.
ReboxetineThe serum concentration of Digitoxin can be increased when it is combined with Reboxetine.
RegorafenibDigitoxin may decrease the cardiotoxic activities of Regorafenib.
RegorafenibThe serum concentration of Digitoxin can be increased when it is combined with Regorafenib.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Digitoxin.
ResveratrolDigitoxin may decrease the cardiotoxic activities of Resveratrol.
Rhodamine 6GDigitoxin may decrease the cardiotoxic activities of Rhodamine 6G.
RibostamycinThe serum concentration of Digitoxin can be decreased when it is combined with Ribostamycin.
RifabutinThe metabolism of Digitoxin can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Digitoxin can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Digitoxin can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Digitoxin can be increased when it is combined with Rilpivirine.
RitonavirThe serum concentration of Digitoxin can be decreased when it is combined with Ritonavir.
RituximabDigitoxin may decrease the cardiotoxic activities of Rituximab.
RolapitantThe serum concentration of Digitoxin can be increased when it is combined with Rolapitant.
RomidepsinDigitoxin may decrease the cardiotoxic activities of Romidepsin.
RomiplostimDigitoxin may decrease the cardiotoxic activities of Romiplostim.
RoquinimexDigitoxin may decrease the cardiotoxic activities of Roquinimex.
RubitecanDigitoxin may decrease the cardiotoxic activities of Rubitecan.
RuxolitinibDigitoxin may decrease the cardiotoxic activities of Ruxolitinib.
SaquinavirThe serum concentration of Digitoxin can be decreased when it is combined with Saquinavir.
SatraplatinDigitoxin may decrease the cardiotoxic activities of Satraplatin.
ScopolamineThe serum concentration of Digitoxin can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Digitoxin can be increased when it is combined with Selegiline.
SeliciclibDigitoxin may decrease the cardiotoxic activities of Seliciclib.
SemaxanibDigitoxin may decrease the cardiotoxic activities of Semaxanib.
SeocalcitolDigitoxin may decrease the cardiotoxic activities of Seocalcitol.
SertralineThe serum concentration of Digitoxin can be increased when it is combined with Sertraline.
SildenafilThe metabolism of Digitoxin can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Digitoxin can be decreased when it is combined with Siltuximab.
SiltuximabDigitoxin may decrease the cardiotoxic activities of Siltuximab.
SimeprevirThe serum concentration of Digitoxin can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Digitoxin can be increased when it is combined with Simvastatin.
SirolimusDigitoxin may decrease the cardiotoxic activities of Sirolimus.
SirolimusThe serum concentration of Digitoxin can be decreased when it is combined with Sirolimus.
SonidegibDigitoxin may decrease the cardiotoxic activities of Sonidegib.
SorafenibDigitoxin may decrease the cardiotoxic activities of Sorafenib.
SorafenibThe serum concentration of Digitoxin can be increased when it is combined with Sorafenib.
SotalolSotalol may increase the bradycardic activities of Digitoxin.
SparfloxacinDigitoxin may decrease the cardiotoxic activities of Sparfloxacin.
Sparfosic acidDigitoxin may decrease the cardiotoxic activities of Sparfosic acid.
SparsomycinDigitoxin may decrease the cardiotoxic activities of Sparsomycin.
SpectinomycinThe serum concentration of Digitoxin can be decreased when it is combined with Spectinomycin.
SpironolactoneThe therapeutic efficacy of Digitoxin can be decreased when used in combination with Spironolactone.
squalamineDigitoxin may decrease the cardiotoxic activities of squalamine.
SRT501Digitoxin may decrease the cardiotoxic activities of SRT501.
St. John's WortThe serum concentration of Digitoxin can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Digitoxin can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Digitoxin can be increased when it is combined with Stiripentol.
StreptomycinThe serum concentration of Digitoxin can be decreased when it is combined with Streptomycin.
StreptozocinDigitoxin may decrease the cardiotoxic activities of Streptozocin.
StreptozocinThe serum concentration of Digitoxin can be decreased when it is combined with Streptozocin.
SulfasalazineThe serum concentration of Digitoxin can be decreased when it is combined with Sulfasalazine.
SulfinpyrazoneThe serum concentration of Digitoxin can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Digitoxin can be decreased when combined with Sulfisoxazole.
SulindacDigitoxin may decrease the cardiotoxic activities of Sulindac.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Digitoxin.
SumatriptanThe serum concentration of Digitoxin can be increased when it is combined with Sumatriptan.
SunitinibDigitoxin may decrease the cardiotoxic activities of Sunitinib.
SunitinibThe serum concentration of Digitoxin can be increased when it is combined with Sunitinib.
SuraminDigitoxin may decrease the cardiotoxic activities of Suramin.
SwainsonineDigitoxin may decrease the cardiotoxic activities of Swainsonine.
TacrineThe serum concentration of Digitoxin can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Digitoxin can be decreased when it is combined with Tacrolimus.
TamoxifenDigitoxin may decrease the cardiotoxic activities of Tamoxifen.
TamoxifenThe serum concentration of Digitoxin can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Digitoxin can be increased when it is combined with Taurocholic Acid.
TegafurDigitoxin may decrease the cardiotoxic activities of Tegafur.
TelaprevirThe metabolism of Digitoxin can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Digitoxin can be decreased when combined with Telithromycin.
TelmisartanThe serum concentration of Digitoxin can be increased when it is combined with Telmisartan.
TemafloxacinDigitoxin may decrease the cardiotoxic activities of Temafloxacin.
TemozolomideDigitoxin may decrease the cardiotoxic activities of Temozolomide.
TemsirolimusDigitoxin may decrease the cardiotoxic activities of Temsirolimus.
TemsirolimusThe serum concentration of Digitoxin can be increased when it is combined with Temsirolimus.
TeniposideDigitoxin may decrease the cardiotoxic activities of Teniposide.
TerazosinThe serum concentration of Digitoxin can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Digitoxin can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Digitoxin can be decreased when it is combined with Tesmilifene.
TestolactoneDigitoxin may decrease the cardiotoxic activities of Testolactone.
TestosteroneThe serum concentration of Digitoxin can be increased when it is combined with Testosterone.
TetrathiomolybdateDigitoxin may decrease the cardiotoxic activities of Tetrathiomolybdate.
TezacitabineDigitoxin may decrease the cardiotoxic activities of Tezacitabine.
ThalidomideDigitoxin may decrease the cardiotoxic activities of Thalidomide.
ThiotepaDigitoxin may decrease the cardiotoxic activities of Thiotepa.
ThymalfasinDigitoxin may decrease the cardiotoxic activities of Thymalfasin.
TiboloneDigitoxin may decrease the cardiotoxic activities of Tibolone.
TicagrelorThe serum concentration of Digitoxin can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Digitoxin can be decreased when combined with Ticlopidine.
TimololTimolol may increase the bradycardic activities of Digitoxin.
TioguanineDigitoxin may decrease the cardiotoxic activities of Tioguanine.
TipifarnibDigitoxin may decrease the cardiotoxic activities of Tipifarnib.
TirapazamineDigitoxin may decrease the cardiotoxic activities of Tirapazamine.
TobramycinThe serum concentration of Digitoxin can be decreased when it is combined with Tobramycin.
TocilizumabThe serum concentration of Digitoxin can be decreased when it is combined with Tocilizumab.
TolvaptanThe serum concentration of Digitoxin can be increased when it is combined with Tolvaptan.
TopotecanDigitoxin may decrease the cardiotoxic activities of Topotecan.
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Digitoxin.
ToremifeneDigitoxin may decrease the cardiotoxic activities of Toremifene.
TositumomabDigitoxin may decrease the cardiotoxic activities of Tositumomab.
TrabectedinDigitoxin may decrease the cardiotoxic activities of Trabectedin.
TrametinibDigitoxin may decrease the cardiotoxic activities of Trametinib.
TrastuzumabDigitoxin may decrease the cardiotoxic activities of Trastuzumab.
Trastuzumab emtansineDigitoxin may decrease the cardiotoxic activities of Trastuzumab emtansine.
TrazodoneThe serum concentration of Digitoxin can be decreased when it is combined with Trazodone.
TretinoinDigitoxin may decrease the cardiotoxic activities of Tretinoin.
TriamtereneThe therapeutic efficacy of Digitoxin can be decreased when used in combination with Triamterene.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Trichlormethiazide is combined with Digitoxin.
TrifluoperazineThe serum concentration of Digitoxin can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Digitoxin can be increased when it is combined with Triflupromazine.
TrifluridineDigitoxin may decrease the cardiotoxic activities of Trifluridine.
TrilostaneDigitoxin may decrease the cardiotoxic activities of Trilostane.
TrimethoprimThe serum concentration of Digitoxin can be decreased when it is combined with Trimethoprim.
TrimetrexateDigitoxin may decrease the cardiotoxic activities of Trimetrexate.
TrimipramineThe serum concentration of Digitoxin can be increased when it is combined with Trimipramine.
TriptorelinDigitoxin may decrease the cardiotoxic activities of Triptorelin.
TroleandomycinThe serum concentration of Digitoxin can be increased when it is combined with Troleandomycin.
TrovafloxacinDigitoxin may decrease the cardiotoxic activities of Trovafloxacin.
TroxacitabineDigitoxin may decrease the cardiotoxic activities of Troxacitabine.
TTNPBDigitoxin may decrease the cardiotoxic activities of TTNPB.
TubercidinDigitoxin may decrease the cardiotoxic activities of Tubercidin.
UbenimexDigitoxin may decrease the cardiotoxic activities of Ubenimex.
Uracil mustardDigitoxin may decrease the cardiotoxic activities of Uracil mustard.
ValrubicinDigitoxin may decrease the cardiotoxic activities of Valrubicin.
VandetanibDigitoxin may decrease the cardiotoxic activities of Vandetanib.
VapreotideDigitoxin may decrease the cardiotoxic activities of Vapreotide.
VeliparibDigitoxin may decrease the cardiotoxic activities of Veliparib.
VemurafenibDigitoxin may decrease the cardiotoxic activities of Vemurafenib.
VenlafaxineThe metabolism of Digitoxin can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Digitoxin can be decreased when combined with Verapamil.
VerteporfinDigitoxin may decrease the cardiotoxic activities of Verteporfin.
VinblastineDigitoxin may decrease the cardiotoxic activities of Vinblastine.
VinblastineThe serum concentration of Digitoxin can be decreased when it is combined with Vinblastine.
VincristineDigitoxin may decrease the cardiotoxic activities of Vincristine.
VincristineThe serum concentration of Digitoxin can be decreased when it is combined with Vincristine.
VindesineDigitoxin may decrease the cardiotoxic activities of Vindesine.
VinorelbineDigitoxin may decrease the cardiotoxic activities of Vinorelbine.
VinorelbineThe serum concentration of Digitoxin can be increased when it is combined with Vinorelbine.
VismodegibDigitoxin may decrease the cardiotoxic activities of Vismodegib.
Vitamin ADigitoxin may decrease the cardiotoxic activities of Vitamin A.
VoriconazoleThe metabolism of Digitoxin can be decreased when combined with Voriconazole.
VorinostatDigitoxin may decrease the cardiotoxic activities of Vorinostat.
ZimelidineThe serum concentration of Digitoxin can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Digitoxin can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid avocado.
  • Avoid bran and high fiber foods within 2 hours of taking this medication.
  • Avoid excess salt/sodium unless otherwise instructed by your physician.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Avoid salt substitutes containing potassium.
  • Limit garlic, ginger, gingko, and horse chestnut.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Steroid hormone binding
Specific Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
P05023
Molecular Weight:
112895.01 Da
References
  1. Chen JJ, Wang PS, Chien EJ, Wang SW: Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. Br J Pharmacol. 2001 Apr;132(8):1761-8. [PubMed:11309248 ]
  2. Marcus FI, Ryan JN, Stafford MG: The reactivity of derivatives of digoxin and digitoxin as measured by the Na-K-atpase displacement assay and by radioimmunoassay. J Lab Clin Med. 1975 Apr;85(4):610-20. [PubMed:123547 ]
  3. Prignitz R, Frohlich D, Hoffmeister G: [Influence of roentgen rays on electrolyte changes and metabolism of the myocardium. VII. Radiation-induced inhibition of the sodium- and potassium--activated microscomal-trasport ATPase]. Strahlentherapie. 1976 Apr;151(4):356-65. [PubMed:131389 ]
  4. Bluschke V, Bonn R, Greeff K: Increase in the (Na+ + K+)-ATPase activity in heart muscle after chronic treatment with digitoxin or potassium deficient diet. Eur J Pharmacol. 1976 May;37(1):189-91. [PubMed:132355 ]
  5. Fricke U: [New aspects on the mode of action of cardiac glycosides]. Fortschr Med. 1976 Nov 11;94(32):1037-45. [PubMed:136410 ]
  6. Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Muller-Ehmsen J: Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur J Pharmacol. 2009 Nov 10;622(1-3):7-14. doi: 10.1016/j.ejphar.2009.08.039. Epub 2009 Sep 12. [PubMed:19751721 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Wang SW, Lin H, Hwang JJ, Wang PS: Inhibition of testosterone secretion by digitoxin in rat testicular interstitial cells. J Cell Biochem. 1999 Jul 1;74(1):74-80. [PubMed:10381263 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Hage DS, Sengupta A: Characterisation of the binding of digitoxin and acetyldigitoxin to human serum albumin by high-performance affinity chromatography. J Chromatogr B Biomed Sci Appl. 1999 Mar 5;724(1):91-100. [PubMed:10202961 ]
  2. Dasgupta A, Vega AE, Wells A, Datta P: Sensitive methods for determination of free digitoxin concentration using digitoxin immunoassays: demonstration of elevated free digitoxin concentration caused by digitoxin-phenytoin interaction by applying these new techniques. Ther Drug Monit. 1999 Dec;21(6):625-30. [PubMed:10604823 ]
  3. Datta P, Dasgupta A: Interactions between drugs and Asian medicine: displacement of digitoxin from protein binding site by bufalin, the constituent of Chinese medicines Chan Su and Lu-Shen-Wan. Ther Drug Monit. 2000 Apr;22(2):155-9. [PubMed:10774625 ]
  4. Dasgupta A, Paul A, Wells A: Uremic sera contain inhibitors that block digitoxin-valproic acid interaction. Am J Med Sci. 2001 Oct;322(4):204-8. [PubMed:11678517 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first...
Gene Name:
SLCO4C1
Uniprot ID:
Q6ZQN7
Molecular Weight:
78947.525 Da
References
  1. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. [PubMed:14993604 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Pauli-Magnus C, Murdter T, Godel A, Mettang T, Eichelbaum M, Klotz U, Fromm MF: P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43. [PubMed:11284449 ]
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Drug created on July 08, 2007 11:03 / Updated on August 17, 2016 12:23