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targets (6)
for drugs
Identification
Name Alpha-Phosphoribosylpyrophosphoric Acid
Accession Number DB01632 (EXPT02663)
Type small molecule
Groups experimental
Description

The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names
Name Company
5-Phospho-alpha-D-ribose 1-diphosphate
5-Phosphoribosyl 1-pyrophosphate
5-Phosphoribosyl diphosphate
5-PHOSPHORYLRIBOSE-1-PYROPHOSPHATE
Phosphoribosyl pyrophosphate
Phosphoribosylpyrophosphate
PRP
PRPP
Ribofuranose, 5-phosphate 1-pyrophosphate
Brand mixtures Not Available
Categories Not Available
CAS number 13270-65-0
Weight Average: 390.0696
Monoisotopic: 389.95181466
Chemical Formula C5H13O14P3
InChI Key InChIKey=PQGCEDQWHSBAJP-TXICZTDVSA-N
InChI
InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1
Plain Text
IUPAC Name
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid
SMILES
O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 1.16e+01 g/l ALOGPS
logP -0.74 ALOGPS
logP -3 ChemAxon
logS -1.5 ALOGPS
pKa (strongest acidic) 1.09 ChemAxon
pKa (strongest basic) -3.7 ChemAxon
physiological charge -4 ChemAxon
hydrogen acceptor count 11 ChemAxon
hydrogen donor count 7 ChemAxon
polar surface area 229.74 ChemAxon
rotatable bond count 7 ChemAxon
refractivity 62.58 ChemAxon
polarizability 27.45 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
PubChem Compound 7339 Link_out
PubChem Substance 46506467 Link_out
ChemSpider 1012 Link_out
BindingDB 25315 Link_out
ChEBI 17111 Link_out
ChEMBL 17111 Link_out
HET PRP Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Hypoxanthine-guanine phosphoribosyltransferase, putative

Pharmacological action: unknown

GMP + diphosphate = guanine + 5-phospho-alpha- D-ribose 1-diphosphate

Organism class: parasitic
UniProt ID: Q27796 Link_out
Gene: HGPRTase
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

2. Adenine phosphoribosyltransferase

Pharmacological action: unknown

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Organism class: human
UniProt ID: P07741 Link_out
Gene: APRT Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. Anthranilate phosphoribosyltransferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q8VP84 Link_out
Gene: trpD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

4. Hypoxanthine-guanine phosphoribosyltransferase

Pharmacological action: unknown
Organism class: human
UniProt ID: P00492 Link_out
Gene: HPRT1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

5. Orotate phosphoribosyltransferase

Pharmacological action: unknown

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

Organism class: bacterial
UniProt ID: P08870 Link_out
Gene: pyrE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Uridine-cytidine kinase-like 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9NWZ5 Link_out
Gene: UCKL1
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:20