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Identification
NameCoenzyme A
Accession NumberDB01992  (EXPT00991)
Typesmall molecule
Groupsnutraceutical
Description

Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as a substrate. In humans, CoA biosynthesis requires cysteamine, pantothenate, and adenosine triphosphate. [Wikipedia]. It is used as a supplement for the hypothetical treatment of acne.

Structure
Thumb
Synonyms
SynonymLanguageCode
3'-phosphoadenosine-(5')diphospho(4')pantatheineNot AvailableNot Available
CoANot AvailableNot Available
CoA-SHNot AvailableNot Available
CoASHNot AvailableNot Available
HSCoANot AvailableNot Available
SaltsNot Available
Brand namesNot Available
Brand mixturesNot Available
CategoriesNot Available
CAS number85-61-0
WeightAverage: 767.534
Monoisotopic: 767.115208365
Chemical FormulaC21H36N7O16P3S
InChI KeyInChIKey=RGJOEKWQDUBAIZ-VPHNIEJBSA-N
InChI
InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14+,15-,16-,20+/m0/s1
IUPAC Name
{[(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid
SMILES
CC(C)(CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H]1O[C@H]([C@H](O)[C@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassOrganooxygen Compounds
ClassCarbohydrates and Carbohydrate Conjugates
SubclassGlycosyl Compounds
Direct parentCoenzyme A and Derivatives
Alternative parentsPurine Ribonucleoside Diphosphates; Glycoamino Acids and Derivatives; Pentose Phosphates; Beta Amino Acids and Derivatives; Organic Pyrophosphates; Monosaccharide Phosphates; Purines and Purine Derivatives; Aminopyrimidines and Derivatives; Primary Aromatic Amines; Organophosphate Esters; N-substituted Imidazoles; Organic Phosphoric Acids; Tetrahydrofurans; Oxolanes; Secondary Carboxylic Acid Amides; Secondary Alcohols; Carboxylic Acids; Enolates; Ethers; Polyamines; Alkylthiols; Aldehydes
Substituentspurine ribonucleoside diphosphate; glyco amino acid; pentose-5-phosphate; pentose phosphate; beta amino acid or derivative; organic pyrophosphate; monosaccharide phosphate; pentose monosaccharide; imidazopyrimidine; purine; aminopyrimidine; n-substituted imidazole; organic phosphate; monosaccharide; phosphoric acid ester; primary aromatic amine; pyrimidine; tetrahydrofuran; imidazole; azole; oxolane; secondary carboxylic acid amide; secondary alcohol; carboxamide group; polyamine; carboxylic acid; alkylthiol; enolate; ether; carboxylic acid derivative; primary amine; alcohol; organonitrogen compound; amine; aldehyde
Classification descriptionThis compound belongs to the coenzyme a and derivatives. These are derivative of vitamin B5 containing a 4'-phosphopantetheine moiety attached to a diphospho-adenosine.
Pharmacology
IndicationNot Available
PharmacodynamicsNot Available
Mechanism of actionNot Available
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.7401
Blood Brain Barrier - 0.7907
Caco-2 permeable - 0.7208
P-glycoprotein substrate Substrate 0.76
P-glycoprotein inhibitor I Non-inhibitor 0.6842
P-glycoprotein inhibitor II Non-inhibitor 0.9863
Renal organic cation transporter Non-inhibitor 0.9581
CYP450 2C9 substrate Non-substrate 0.8266
CYP450 2D6 substrate Non-substrate 0.7883
CYP450 3A4 substrate Substrate 0.5836
CYP450 1A2 substrate Non-inhibitor 0.8318
CYP450 2C9 substrate Non-inhibitor 0.8355
CYP450 2D6 substrate Non-inhibitor 0.842
CYP450 2C19 substrate Non-inhibitor 0.8115
CYP450 3A4 substrate Non-inhibitor 0.8203
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9333
Ames test Non AMES toxic 0.667
Carcinogenicity Non-carcinogens 0.8271
Biodegradation Not ready biodegradable 1.0
Rat acute toxicity 2.6158 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.944
hERG inhibition (predictor II) Non-inhibitor 0.6083
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
Statesolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
water solubility4.64e+00 g/lALOGPS
logP-0.61ALOGPS
logP-6.8ChemAxon
logS-2.2ALOGPS
pKa (strongest acidic)0.83ChemAxon
pKa (strongest basic)4.95ChemAxon
physiological charge-4ChemAxon
hydrogen acceptor count16ChemAxon
hydrogen donor count10ChemAxon
polar surface area346.56ChemAxon
rotatable bond count18ChemAxon
refractivity162.74ChemAxon
polarizability67.1ChemAxon
number of rings3ChemAxon
bioavailability0ChemAxon
rule of fiveNoChemAxon
Ghose filterNoChemAxon
Veber's ruleNoChemAxon
MDDR-like ruleYesChemAxon
Spectra
SpectraNot Available
References
Synthesis Reference

Shigeru Ikuta, Shigeyuki Imamura, Hidehiko Ishikawa, Kazuo Matsuura, Masaki Takada, Hideo Misaki, “Process for the production of acyl-Coenzyme A oxidase.” U.S. Patent US4346173, issued September, 1980.

US4346173
General ReferenceNot Available
External Links
ResourceLink
KEGG CompoundC00010
PubChem Compound46936280
PubChem Substance46507023
ChemSpider311
ChEBI15346
ChEMBL
HETCOA
WikipediaCoenzyme_A
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

1. Acetyl-coenzyme A synthetase

Kind: protein

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Pharmacological action: unknown

Components

Name UniProt ID Details
Acetyl-coenzyme A synthetase Q8ZKF6 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. Acyl-CoA-binding protein

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Acyl-CoA-binding protein P07108 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

3. Formyl-coenzyme A transferase

Kind: protein

Organism: Shigella flexneri

Pharmacological action: unknown

Components

Name UniProt ID Details
Formyl-coenzyme A transferase P69903 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Carnitine O-acetyltransferase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Carnitine O-acetyltransferase P43155 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

5. Crotonobetainyl-CoA:carnitine CoA-transferase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Crotonobetainyl-CoA:carnitine CoA-transferase P31572 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Formate acetyltransferase 1

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Formate acetyltransferase 1 P09373 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. Malate synthase G

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
Malate synthase G P0A5J4 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

8. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Kind: protein

Organism: Pseudomonas mevalonii

Pharmacological action: unknown

Components

Name UniProt ID Details
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. Phosphopantetheine adenylyltransferase

Kind: protein

Organism: Shigella flexneri

Pharmacological action: unknown

Components

Name UniProt ID Details
Phosphopantetheine adenylyltransferase P0A6I8 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

10. Holo-[acyl-carrier-protein] synthase

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
Holo-[acyl-carrier-protein] synthase P96618 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

11. Protease synthase and sporulation negative regulatory protein PAI 1

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
Protease synthase and sporulation negative regulatory protein PAI 1 P21340 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

12. Gentamicin 3'-acetyltransferase

Kind: protein

Organism: Pseudomonas aeruginosa

Pharmacological action: unknown

Components

Name UniProt ID Details
Gentamicin 3'-acetyltransferase P23181 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. Galactoside O-acetyltransferase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Galactoside O-acetyltransferase P07464 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

14. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. Fatty acid metabolism regulator protein

Kind: protein

Organism: Shigella flexneri

Pharmacological action: unknown

Components

Name UniProt ID Details
Fatty acid metabolism regulator protein P0A8V9 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. Histone acetyltransferase KAT5

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Histone acetyltransferase KAT5 Q92993 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

17. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Kind: protein

Organism: Unknown prokaryotic organism

Pharmacological action: unknown

Components

Name UniProt ID Details
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase P56220 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

18. Acetyl-CoA acetyltransferase, cytosolic

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Acetyl-CoA acetyltransferase, cytosolic Q9BWD1 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

19. Acetyl-CoA acetyltransferase

Kind: protein

Organism: Zoogloea ramigera

Pharmacological action: unknown

Components

Name UniProt ID Details
Acetyl-CoA acetyltransferase P07097 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

20. Streptogramin A acetyltransferase

Kind: protein

Organism: Enterococcus faecium

Pharmacological action: unknown

Components

Name UniProt ID Details
Streptogramin A acetyltransferase P50870 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

21. Citrate synthase, mitochondrial

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Citrate synthase, mitochondrial O75390 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

22. 3-oxoacyl-[acyl-carrier-protein] synthase 3

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
3-oxoacyl-[acyl-carrier-protein] synthase 3 P0A6R0 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

23. Formyl-coenzyme A transferase

Kind: protein

Organism: Oxalobacter formigenes

Pharmacological action: unknown

Components

Name UniProt ID Details
Formyl-coenzyme A transferase O06644 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

24. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Kind: protein

Organism: Azotobacter vinelandii

Pharmacological action: unknown

Components

Name UniProt ID Details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex P10802 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

25. Pantothenate kinase

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Pantothenate kinase P0A6I3 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

26. Acetyl transferase

Kind: protein

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Pharmacological action: unknown

Components

Name UniProt ID Details
Acetyl transferase Q8ZPC0 Details

27. Uncharacterized N-acetyltransferase YvbK

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
Uncharacterized N-acetyltransferase YvbK O32248 Details

28. Aminoglycoside N(6')-acetyltransferase type 1

Kind: protein

Organism: Salmonella enteritidis

Pharmacological action: unknown

Components

Name UniProt ID Details
Aminoglycoside N(6')-acetyltransferase type 1 Q9R381 Details

29. Acyl-CoA hydrolase

Kind: protein

Organism: Bacillus cereus (strain ATCC 14579 / DSM 31)

Pharmacological action: unknown

Components

Name UniProt ID Details
Acyl-CoA hydrolase Q81EE4 Details

30. Uncharacterized acyl-CoA thioester hydrolase HI_0827

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: unknown

Components

Name UniProt ID Details
Uncharacterized acyl-CoA thioester hydrolase HI_0827 P44886 Details

31. 3-oxoacyl-[acyl-carrier-protein] synthase 3

Kind: protein

Organism: Streptomyces lividans

Pharmacological action: unknown

Components

Name UniProt ID Details
3-oxoacyl-[acyl-carrier-protein] synthase 3 Q9F6D4 Details

32. Mycothiol acetyltransferase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
Mycothiol acetyltransferase O53831 Details

33. Histone acetyltransferase KAT2A

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Histone acetyltransferase KAT2A Q92830 Details

References:

  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

34. Acyl-CoA hydrolase

Kind: protein

Organism: Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

Pharmacological action: unknown

Components

Name UniProt ID Details
Acyl-CoA hydrolase Q9KEQ1 Details

35. Histone acetyltransferase KAT2B

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Histone acetyltransferase KAT2B Q92831 Details

36. 1,4-Dihydroxy-2-naphthoyl-CoA synthase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
1,4-Dihydroxy-2-naphthoyl-CoA synthase O06414 Details

37. Citrate synthase

Kind: protein

Organism: Thermus thermophilus

Pharmacological action: unknown

Components

Name UniProt ID Details
Citrate synthase Q9LCX9 Details

38. Aminoglycoside 2'-N-acetyltransferase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
Aminoglycoside 2'-N-acetyltransferase P0A5N0 Details

39. Aac(6')-Ii protein

Kind: protein

Organism: Enterococcus faecium

Pharmacological action: unknown

Components

Name UniProt ID Details
Aac(6')-Ii protein Q47764 Details

40. 4'-phosphopantetheinyl transferase sfp

Kind: protein

Organism: Bacillus subtilis (strain 168)

Pharmacological action: unknown

Components

Name UniProt ID Details
4'-phosphopantetheinyl transferase sfp P39135 Details

41. Uncharacterized protein

Kind: protein

Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Pharmacological action: unknown

Components

Name UniProt ID Details
Uncharacterized protein Q9HYX1 Details

42. Serine acetyltransferase

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: unknown

Components

Name UniProt ID Details
Serine acetyltransferase P43886 Details

43. Citrate synthase

Kind: protein

Organism: Antarctic bacterium DS2-3R

Pharmacological action: unknown

Components

Name UniProt ID Details
Citrate synthase O34002 Details

44. 4-hydroxybenzoyl-CoA thioesterase

Kind: protein

Organism: Arthrobacter sp.

Pharmacological action: unknown

Components

Name UniProt ID Details
4-hydroxybenzoyl-CoA thioesterase Q04416 Details

45. Bifunctional protein GlmU

Kind: protein

Organism: Escherichia coli (strain K12)

Pharmacological action: unknown

Components

Name UniProt ID Details
Bifunctional protein GlmU P0ACC7 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

1. Aminoglycoside 2'-N-acetyltransferase

Kind: protein

Organism: Mycobacterium tuberculosis

Pharmacological action: unknown

Components

Name UniProt ID Details
Aminoglycoside 2'-N-acetyltransferase P0A5N0 Details
Comments
Drug created on June 13, 2005 07:24 / Updated on September 30, 2013 15:39