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targets (17)
for drugs
Identification
Name Sucrose
Accession Number DB02772 (EXPT02977)
Type small molecule
Groups experimental
Description

A nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons. It is obtained commercially from sugarcane, sugar beet (beta vulgaris), and other plants and used extensively as a food and a sweetener. [PubChem]
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories
  • Sweetening Agents
CAS number 57-50-1
Weight Average: 342.2965
Monoisotopic: 342.116211546
Chemical Formula C12H22O11
InChI Key InChIKey=CZMRCDWAGMRECN-MTNNYNCSSA-N
InChI
InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11+,12+/m0/s1
Plain Text
IUPAC Name
(2R,3S,4R,5R,6S)-2-{[(2R,3R,4R,5S)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES
OC[C@@H]1O[C@](CO)(O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H]1O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties
Property Value Source
melting point 185.5 °C PhysProp
water solubility 2.1E+006 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP -3.70 HANSCH,C ET AL. (1995)
Caco2 permeability -5.77 ADME Research, USCD
pKa 12.6 MERCK INDEX (1996)
Predicted Properties
Property Value Source
water solubility 8.24e+02 g/l ALOGPS
logP -2.6 ALOGPS
logP -4.5 ChemAxon
logS 0.38 ALOGPS
pKa (strongest acidic) 11.84 ChemAxon
pKa (strongest basic) -3 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 11 ChemAxon
hydrogen donor count 8 ChemAxon
polar surface area 189.53 ChemAxon
rotatable bond count 5 ChemAxon
refractivity 68.77 ChemAxon
polarizability 31.32 ChemAxon
References
Synthesis Reference Not Available
General Reference
  1. Ten S, Maclaren N: Insulin resistance syndrome in children. J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39. Pubmed
  2. Aguilera AA, Diaz GH, Barcelata ML, Guerrero OA, Ros RM: Effects of fish oil on hypertension, plasma lipids, and tumor necrosis factor-alpha in rats with sucrose-induced metabolic syndrome. J Nutr Biochem. 2004 Jun;15(6):350-7. Pubmed
  3. Fukuchi S, Hamaguchi K, Seike M, Himeno K, Sakata T, Yoshimatsu H: Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats. Exp Biol Med (Maywood). 2004 Jun;229(6):486-93. Pubmed
  4. Lombardo YB, Drago S, Chicco A, Fainstein-Day P, Gutman R, Gagliardino JJ, Gomez Dumm CL: Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas. Metabolism. 1996 Dec;45(12):1527-32. Pubmed
External Links
Resource Link
KEGG Drug D00025 Link_out
KEGG Compound C00089 Link_out
PubChem Compound 46936484 Link_out
PubChem Substance 46506134 Link_out
ChEBI 17992 Link_out
ChEMBL 17992 Link_out
PharmGKB PA451525 Link_out
HET SUC Link_out
Drug Product Database 50121 Link_out
RxList http://www.rxlist.com/cgi/generic/venofer.htm Link_out
Wikipedia http://en.wikipedia.org/wiki/Sucrose Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. Beta-glucosidase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q59976 Link_out
Gene: bgl3
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

2. Amylosucrase

Pharmacological action: unknown

Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto the released glucose, and finally turanose and trehalulose synthesis, these two sucrose isomers being obtained by glucosyl transfer onto fructose

Organism class: bacterial
UniProt ID: Q9ZEU2 Link_out
Gene: ams
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

3. Beta-lactamase CTX-M-9a

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9L5C8 Link_out
Gene: blaCTX-M-9a
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

4. Extended-spectrum beta-lactamase CTX-M-14

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9L5C7 Link_out
Gene: blaCTX-M-14
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

5. Heme oxygenase

Pharmacological action: unknown

Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety

Organism class: bacterial
UniProt ID: P71119 Link_out
Gene: hmuO
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

6. Copper transport protein ATOX1

Pharmacological action: unknown

Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense

Organism class: human
UniProt ID: O00244 Link_out
Gene: ATOX1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

7. UPF0027 protein C22orf28

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9Y3I0 Link_out
Gene: C22orf28
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

8. Orange carotenoid-binding protein

Pharmacological action: unknown

Acts as a photo-protectant. Essential for inhibiting white and blue-green light non-photochemical quenching (NPQ). Binding carotenoids improves OCP's intrinsic photoprotectant activity by broadening its absorption spectrum and facilitating the dissipation of absorbed energy

Organism class: bacterial
UniProt ID: P83689 Link_out
Protein Sequence: FASTA

9. Sucrose porin

Pharmacological action: unknown

Porin for sucrose uptake

Organism class: bacterial
UniProt ID: P22340 Link_out
Gene: scrY
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

10. Levansucrase

Pharmacological action: unknown

Sucrose + (2,6-beta-D-fructosyl)(n) = glucose + (2,6-beta-D-fructosyl)(n+1)

Organism class: bacterial
UniProt ID: P05655 Link_out
Gene: sacB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

11. Beta-lactamase CTX-M-27

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q840M4 Link_out
Gene: blaCTX-M-27
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

12. GDP-mannose 6-dehydrogenase

Pharmacological action: unknown

Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics

Organism class: bacterial
UniProt ID: P11759 Link_out
Gene: algD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. Actin, alpha skeletal muscle

Pharmacological action: unknown

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Organism class: human
UniProt ID: P68133 Link_out
Gene: ACTA1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

14. Beta-lactamase

Pharmacological action: unknown

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins

Organism class: bacterial
UniProt ID: P00811 Link_out
Gene: ampC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. Nitric oxide synthase oxygenase

Pharmacological action: unknown

Catalyzes the production of nitric oxide

Organism class: bacterial
UniProt ID: P0A094 Link_out
Gene: nos
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. Lysozyme C

Pharmacological action: unknown
Organism class: human
UniProt ID: P61626 Link_out
Gene: LYZ
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

17. Septum formation protein Maf

Pharmacological action: unknown

Involved in septum formation

Organism class: bacterial
UniProt ID: Q02169 Link_out
Gene: maf
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:21